Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 1821356..1821878 Replicon chromosome
Accession NZ_CP094320
Organism Edwardsiella anguillarum strain 43659

Toxin (Protein)


Gene name relE Uniprot ID C5BBL4
Locus tag MQ089_RS08450 Protein ID WP_015871319.1
Coordinates 1821356..1821637 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID C5BBL3
Locus tag MQ089_RS08455 Protein ID WP_015871318.1
Coordinates 1821627..1821878 (-) Length 84 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MQ089_RS08435 (MQ089_08425) 1816743..1817519 + 777 WP_283294719.1 hypothetical protein -
MQ089_RS08440 (MQ089_08430) 1817512..1819173 + 1662 WP_283294840.1 terminase -
MQ089_RS08445 (MQ089_08435) 1819170..1821284 + 2115 WP_283294720.1 portal protein -
MQ089_RS08450 (MQ089_08440) 1821356..1821637 - 282 WP_015871319.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MQ089_RS08455 (MQ089_08445) 1821627..1821878 - 252 WP_015871318.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MQ089_RS08460 (MQ089_08450) 1822166..1822657 + 492 WP_283294721.1 hypothetical protein -
MQ089_RS08465 (MQ089_08455) 1822644..1822958 + 315 WP_283294722.1 hypothetical protein -
MQ089_RS08470 (MQ089_08460) 1823363..1825237 + 1875 WP_045427621.1 PhoX family phosphatase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1786420..1836440 50020


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(6-84)

Antitoxin


No domain identified.



Sequences


Toxin        


Download         Length: 94 a.a.        Molecular weight: 10783.62 Da        Isoelectric Point: 10.6993

>T239609 WP_015871319.1 NZ_CP094320:c1821637-1821356 [Edwardsiella anguillarum]
MTYKLSFEKRALKEWKKLAPPIQSQLKKKLIERLENPHVPAARLSGRANRYKIKLRSSGYRLVYEVNDSEIILLVIAIGK
RADNEVYQAADSR

Download         Length: 282 bp

>T239609 NZ_LS483252:c2527418-2527167 [Bordetella pertussis]
ATTGGAGGCGCGGCGACAAAAAAGCCGGGACAAAAGCGTCGCGCCGGGGCGGCGGCGCTGGGGCTGGATTTCAGCGCCAT
GGTCGAAATCGTGCTTGCATTGACACCGCGGGATTTCCACAAAAGCATGACTACCCATGCCGACCATCGCATTTGGCAGG
ACGTCTATTGCCCGGTGACAGCGATGGGCGCCGTCTACCTGAAGCTGACGGTCCTCGACGGCGTGCCGATCGTGTCGTTC
AAGGAGTTGTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9155.24 Da        Isoelectric Point: 3.7550

>AT239609 WP_015871318.1 NZ_CP094320:c1821878-1821627 [Edwardsiella anguillarum]
MAYQILTTTAASITDLKRNPMGTIAEGDGNAVAILNRNEPAFYCVPPELYAYYLELAEDAALNRIADERLEDAEFVSVNI
DDL

Download         Length: 252 bp

>AT239609 NZ_LS483252:c2527164-2526763 [Bordetella pertussis]
ATGAAGTGTCCCGTATGCGGAGCGGCCGCGCTGGCGCGTGATACTCGCGATGTGCCCTATAGCTACAAGGGCGAGACCAT
CACGATTGCGGCGGTGACGGGCGACTGGTGTCCGGCATGCGGCGAGAACGTGCTCGATGGCGCTGAATCGGCGCGGGTGA
GCGAGGCCATGCTGGCTTTCAACCGCCTGGTCAACGCCCGCCGCGTCGACCCCGGGTTCATCGTGCGGGTGCGCAGGAAG
CTGGGGCTGGACCAGCGCGAAGCCGCGGCGCTGTTCGGCGGCGGCACCAATGCGTTCTCGCGTTACGAGAACGGCAAGAC
GCGCCCGCCGCTGGCGCTGGTGAAGCTGCTCAGGCTGCTGGATCGCCATCCGGAGCTGCTGGAGGAAGTCCGTGCGGATT
GA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB C5BBL4


Antitoxin

Source ID Structure
AlphaFold DB C5BBL3

References