Detailed information of TA system TA239609

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-DnaT
• Location: 1821356..1821878
• Replicon: chromosome
• Accession: NZ_CP094320
• Organism: Edwardsiella anguillarum strain 43659

Toxin (Protein)

• Gene name: relE
• Uniprot ID: C5BBL4
• Locus tag: MQ089_RS08450
• Protein ID: WP_015871319.1
• Coordinates: 1821356..1821637 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: C5BBL3
• Locus tag: MQ089_RS08455
• Protein ID: WP_015871318.1
• Coordinates: 1821627..1821878 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MQ089_RS08435 (MQ089_08425)	1816743..1817519	+	777	WP_283294719.1	hypothetical protein	-
MQ089_RS08440 (MQ089_08430)	1817512..1819173	+	1662	WP_283294840.1	terminase	-
MQ089_RS08445 (MQ089_08435)	1819170..1821284	+	2115	WP_283294720.1	portal protein	-
MQ089_RS08450 (MQ089_08440)	1821356..1821637	-	282	WP_015871319.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
MQ089_RS08455 (MQ089_08445)	1821627..1821878	-	252	WP_015871318.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
MQ089_RS08460 (MQ089_08450)	1822166..1822657	+	492	WP_283294721.1	hypothetical protein	-
MQ089_RS08465 (MQ089_08455)	1822644..1822958	+	315	WP_283294722.1	hypothetical protein	-
MQ089_RS08470 (MQ089_08460)	1823363..1825237	+	1875	WP_045427621.1	PhoX family phosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1786420..1836440	50020

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-84)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10783.62 Da
• Isoelectric Point: 10.6993

>T239609 WP_015871319.1 NZ_CP094320:c1821637-1821356 [Edwardsiella anguillarum]
MTYKLSFEKRALKEWKKLAPPIQSQLKKKLIERLENPHVPAARLSGRANRYKIKLRSSGYRLVYEVNDSEIILLVIAIGK
RADNEVYQAADSR

Nucleotide

• Length: 282 bp

>T239609 NZ_LS483252:c2527418-2527167 [Bordetella pertussis]
ATTGGAGGCGCGGCGACAAAAAAGCCGGGACAAAAGCGTCGCGCCGGGGCGGCGGCGCTGGGGCTGGATTTCAGCGCCAT
GGTCGAAATCGTGCTTGCATTGACACCGCGGGATTTCCACAAAAGCATGACTACCCATGCCGACCATCGCATTTGGCAGG
ACGTCTATTGCCCGGTGACAGCGATGGGCGCCGTCTACCTGAAGCTGACGGTCCTCGACGGCGTGCCGATCGTGTCGTTC
AAGGAGTTGTGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9155.24 Da
• Isoelectric Point: 3.7550

>AT239609 WP_015871318.1 NZ_CP094320:c1821878-1821627 [Edwardsiella anguillarum]
MAYQILTTTAASITDLKRNPMGTIAEGDGNAVAILNRNEPAFYCVPPELYAYYLELAEDAALNRIADERLEDAEFVSVNI
DDL

Nucleotide

• Length: 252 bp

>AT239609 NZ_LS483252:c2527164-2526763 [Bordetella pertussis]
ATGAAGTGTCCCGTATGCGGAGCGGCCGCGCTGGCGCGTGATACTCGCGATGTGCCCTATAGCTACAAGGGCGAGACCAT
CACGATTGCGGCGGTGACGGGCGACTGGTGTCCGGCATGCGGCGAGAACGTGCTCGATGGCGCTGAATCGGCGCGGGTGA
GCGAGGCCATGCTGGCTTTCAACCGCCTGGTCAACGCCCGCCGCGTCGACCCCGGGTTCATCGTGCGGGTGCGCAGGAAG
CTGGGGCTGGACCAGCGCGAAGCCGCGGCGCTGTTCGGCGGCGGCACCAATGCGTTCTCGCGTTACGAGAACGGCAAGAC
GCGCCCGCCGCTGGCGCTGGTGAAGCTGCTCAGGCTGCTGGATCGCCATCCGGAGCTGCTGGAGGAAGTCCGTGCGGATT
GA

Structures

Toxin

• AlphaFold DB: C5BBL4

Antitoxin

• AlphaFold DB: C5BBL3