Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DhiAT/dnstrm_HI1420(antitoxin)
Location 1809224..1810003 Replicon chromosome
Accession NZ_CP094320
Organism Edwardsiella anguillarum strain 43659

Toxin (Protein)


Gene name dhiT Uniprot ID -
Locus tag MQ089_RS08380 Protein ID WP_198077053.1
Coordinates 1809746..1810003 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name dhiA Uniprot ID -
Locus tag MQ089_RS08375 Protein ID WP_283294710.1
Coordinates 1809224..1809736 (-) Length 171 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MQ089_RS08345 (MQ089_08335) 1804349..1805731 + 1383 WP_283294703.1 replicative DNA helicase -
MQ089_RS08350 (MQ089_08340) 1805759..1806106 + 348 WP_283294704.1 hypothetical protein -
MQ089_RS08355 (MQ089_08345) 1806216..1806860 + 645 WP_034165085.1 DUF1367 family protein -
MQ089_RS08360 (MQ089_08350) 1806863..1807162 + 300 WP_283294705.1 DUF1364 family protein -
MQ089_RS08365 (MQ089_08355) 1807307..1808347 + 1041 WP_283294706.1 hypothetical protein -
MQ089_RS08370 (MQ089_08360) 1808348..1808857 + 510 WP_071525693.1 hypothetical protein -
MQ089_RS08375 (MQ089_08365) 1809224..1809736 - 513 WP_283294710.1 DUF2442 domain-containing protein Antitoxin
MQ089_RS08380 (MQ089_08370) 1809746..1810003 - 258 WP_198077053.1 DUF4160 domain-containing protein Toxin
MQ089_RS08385 (MQ089_08375) 1810373..1811143 + 771 WP_283294713.1 Rha family transcriptional regulator -
MQ089_RS08390 (MQ089_08380) 1811265..1811780 + 516 WP_034165088.1 hypothetical protein -
MQ089_RS08395 (MQ089_08385) 1811869..1812687 + 819 WP_283294714.1 hypothetical protein -
MQ089_RS08400 (MQ089_08390) 1812921..1813319 + 399 WP_144242831.1 hypothetical protein -
MQ089_RS08405 (MQ089_08395) 1813436..1813666 + 231 WP_034165090.1 ParD-like family protein -
MQ089_RS08410 (MQ089_08400) 1813641..1813970 + 330 WP_283294715.1 type II toxin-antitoxin system RelE/ParE family toxin -
MQ089_RS08415 (MQ089_08405) 1814056..1814403 + 348 WP_283294716.1 phage holin, lambda family -
MQ089_RS08420 (MQ089_08410) 1814406..1814957 + 552 WP_283294717.1 glycosyl hydrolase 108 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1786420..1836440 50020


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF4160

(9-74)

Antitoxin

Uncharacterized protein HI1420

(82-161)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9625.29 Da        Isoelectric Point: 7.4665

>T239608 WP_198077053.1 NZ_CP094320:c1810003-1809746 [Edwardsiella anguillarum]
MPEIDALMGLSFVMYFFDNQTHSLPHVHVKYGEFELVIGIDSGEALEGYLPPKKRKLAESHIKANKTRLLAMWQMAVNGM
HPGKL

Download         Length: 258 bp

>T239608 NZ_LS483251:c2743405-2742065 [Bordetella pertussis]
ATGGGGCGCCGATCGCACAGCCGCAGCCTGTCCATCTGGACCAACGGCGTTCGCGTCGGGCGTTGGACGGTTCCCGCTCG
CGGAGAGATGGAACTGCAGTACGACGTGGATTGGGTCCGTGCCGACGTCGGCCGGCCACTTTCGCTGTCGCTGCCATTCA
ACTTGCAGAATCTGCCCCTCAAGGGGGAGAGAGTCGCCAACTACTTCGACAATCTGCTACCGGACAGCGACGCTATCCGT
CGTCGCGTGGCCGAGCGATTCAGGACGGGCTCGGTCGATCCCTTCGATCTGTTGAAAGCCATTGGACGCGATTGCGTTGG
CGCCGTACAGATCCTGGAAGACGAAGAGATACCTGAGGGCTTTGATCGCATCGAGGGCGTGCCTCTGTCCGAGGAGGACA
TCGAGCGGCATTTGATCGAAACCGTTACGCCGCGCGCCTTCGCTGCGGGCCGGGACCCGGACGCGGATTTCAGAATTTCT
CTGGCCGGCGCGCAAGAGAAGACAGCCTTCCTGTGGTGGGGCGGACAGTGGCTTGCGCCGCGTGGCGCGACATCGACGAG
CCATATTTTCAAACTTCCATTGGGCTTGGTGGGTGGACGGCGGGCTGACTTCAGCACTTCTGTTGATAACGAATGGCTGT
GTCTGAAGCTGCTGAAGGCGTATGGGTTGGATGTGGCTGAGGCCAGCATCGCAACCTTCGGACAGCAGCGAGTGCTGGTG
GTCGAGCGATTCGACCGGCGTGTTGCGCCCAACGGGCAATGGCTGATGCGCCTGCCGCAGGAAGATTTCTGCCAGGTCGA
GGGGTGCTCGCCGCTACGCAAGTATGAAAACGAGGGCGGCCCAGGACTCAAGGCCTTATTCGCCACGCTGCGGCAGTCAG
TGAACGCAGCGGTCGATATGAGAACGTTGATGGCGGCGCAGATCCTGTTTTGGTTGCTGCGGGCACCCGATGGCCACGCC
AAGAATTTCAGCATCCAGTTGTTGCCGCGCGGCCGTTTCCAGTTGACTAGACTGTACGACGTGATGTCGGCCTATCCGGT
ACTGGGCGATGGCGCGAATCAGTGGTCGCCGTTCGAAATCAAATTGGCGATGGCATTGATTGGCAAGAACCGGCATTACG
AGATGCACGGCATCCAGCGCAGGCACTTCAACAGCACCGCACAAAAAGTTGGTTATGGCCCGACGGCGGAGCCGATCATT
GAAGACCTGTTGGCCCGTACGCCCGCGATCATTGCCGCCGTGCAGGCCGATTTGCCGCAGGACTTCTCGCCGCGTGTTGC
GGACTCCGTCCTGGGTGGGCTTGCGCAGGCCGCAAAGTCGCTCGGCGCAATGATGCCGTAA

Antitoxin


Download         Length: 171 a.a.        Molecular weight: 18249.67 Da        Isoelectric Point: 7.3201

>AT239608 WP_283294710.1 NZ_CP094320:c1809736-1809224 [Edwardsiella anguillarum]
MLKIIDVDVVGDHVIEVEFSDGFRGRADLTALFSKPPFSAIADFNRFSLTASGVLNWGDAELSADTVRRMSKGAVVSASS
RSLMPENVEAILRQATWESMSEGRPDILQAALRGYAEQLGHADVIKRAGIASRSSAYKTLSPSTNPSFKSLAKISGAILA
IVRENNAQHG

Download         Length: 513 bp

>AT239608 NZ_LS483251:c2743664-2743407 [Bordetella pertussis]
ATGCCGCCGCCATCACAACCTCTGCTCACTACCGGCCAGCTTGGCGCGGTCTTGCAGGCTGCACGCAAAGCACAGGGACT
GACTCAATCGGCCCTGGCCAGTCGTATCGGCCTGAGCCAATCGCGGGTCTCGCACCTGGAGTTGAATGCCCATCAACTGA
GCGTGGAGCAGCTCCTGGCCTGGTGCGCGGCGCTAGGGTTGGAGTTGACGATTGCGACTCGCGGAAGTCCCGCAGGGTCT
TCCGACGCGGATTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References