Detailed information of TA system TA239606

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 3375051..3375714
• Replicon: chromosome
• Accession: NZ_CP094319
• Organism: Edwardsiella anguillarum strain 43651

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: MQ085_RS15430
• Protein ID: WP_283293889.1
• Coordinates: 3375051..3375467 (-)
• Length: 139 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: D0ZDY6
• Locus tag: MQ085_RS15435
• Protein ID: WP_012849755.1
• Coordinates: 3375448..3375714 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MQ085_RS15410 (MQ085_15385)	3370981..3372714	-	1734	WP_283293888.1	single-stranded-DNA-specific exonuclease RecJ	-
MQ085_RS15415 (MQ085_15390)	3372719..3373435	-	717	WP_045426732.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
MQ085_RS15420 (MQ085_15395)	3373463..3374362	-	900	WP_034164688.1	site-specific tyrosine recombinase XerD	-
MQ085_RS15425 (MQ085_15400)	3374514..3375026	+	513	WP_034164689.1	flavodoxin FldB	-
MQ085_RS15430 (MQ085_15405)	3375051..3375467	-	417	WP_283293889.1	protein YgfX	Toxin
MQ085_RS15435 (MQ085_15410)	3375448..3375714	-	267	WP_012849755.1	FAD assembly factor SdhE	Antitoxin
MQ085_RS15440 (MQ085_15415)	3376063..3377061	+	999	WP_283293890.1	tRNA-modifying protein YgfZ	-
MQ085_RS15445 (MQ085_15420)	3377103..3377927	-	825	WP_034164693.1	shikimate 5-dehydrogenase	-
MQ085_RS15450 (MQ085_15425)	3378084..3378956	-	873	WP_034164695.1	nucleoside-specific channel-forming protein Tsx	-
MQ085_RS15455 (MQ085_15430)	3379565..3380215	+	651	WP_034164746.1	hemolysin III family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-131)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 139 a.a.
• Molecular weight: 16229.03 Da
• Isoelectric Point: 11.6049

>T239606 WP_283293889.1 NZ_CP094319:c3375467-3375051 [Edwardsiella anguillarum]
VVLWRCNVHVSWRTQVMFLLGHGALVLAILLAPWPENYSAFWLVLLVAVIFECIRSQRRIARNRGELQLLAPQVWHWQLR
EWRLARRPWVSDLGALLILQSTHGVPCRRRLWLAADSMSREEWGQLRRTLLDTGDDRA

Nucleotide

• Length: 417 bp

>T239606 NZ_LS483250:c3949437-3949186 [Moritella yayanosii]
ATGAGCGTCGTAACATTTTCAGAAGCTCGCAATAACTTTAAATCAATCTGTGATTCAGCCGTTGATGATTGTGAACCAGT
GCATATACACAGGCGTGGGGGCGAAGATGTAGTCTTATTATCTGCATCTGAATTCAACGCTTGGAAAGAAACCATGTACT
TGATGGCGAACCCGAATAATTCAAAACGTCTACTTGAATCAATTGCCCAAGCAGAGCACGGAGAAGTACTTAATAAAGAA
TTGTTAGATTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10318.90 Da
• Isoelectric Point: 5.6951

>AT239606 WP_012849755.1 NZ_CP094319:c3375714-3375448 [Edwardsiella anguillarum]
MDINNKARVHWACRRGMRELDIAIMPFFEHEYDALNDADKQTFVRLLACDDPELFKWLMNQGKPDDADLARMITLIQTRN
KERGPLAL

Nucleotide

• Length: 267 bp

>AT239606 NZ_LS483250:c3949186-3948923 [Moritella yayanosii]
ATGCGGAATATACTTTTTACCCCACATGCTTGGGAAGATTATACATATTGGCAGACGCAAGATAAGCGAACGCTGAAACG
CATCAACAAACTCATCGAAGCGGTGCAACGTATGCCATTTGAAGGCATAGGCAAACCAGAACCCCTTAAAGAGAATTTAA
CTGGTTATTGGTCTCGACGTATTAATGATGAACATCGCCTAGTATATAAAGCGGGCGATGATGTTGTTACGATCGTCAGC
ACTCGATTTCATTATGGTAAATAG

Structures

Antitoxin

• AlphaFold DB: A0A034T2Q8