Detailed information of TA system TA239597

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-DnaT
• Location: 1821355..1821877
• Replicon: chromosome
• Accession: NZ_CP094319
• Organism: Edwardsiella anguillarum strain 43651

Toxin (Protein)

• Gene name: relE
• Uniprot ID: C5BBL4
• Locus tag: MQ085_RS08460
• Protein ID: WP_015871319.1
• Coordinates: 1821355..1821636 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: C5BBL3
• Locus tag: MQ085_RS08465
• Protein ID: WP_015871318.1
• Coordinates: 1821626..1821877 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MQ085_RS08445 (MQ085_08435)	1816742..1817518	+	777	WP_283294719.1	hypothetical protein	-
MQ085_RS08450 (MQ085_08440)	1817511..1819172	+	1662	WP_283294840.1	terminase	-
MQ085_RS08455 (MQ085_08445)	1819169..1821283	+	2115	WP_283294720.1	portal protein	-
MQ085_RS08460 (MQ085_08450)	1821355..1821636	-	282	WP_015871319.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
MQ085_RS08465 (MQ085_08455)	1821626..1821877	-	252	WP_015871318.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
MQ085_RS08470 (MQ085_08460)	1822165..1822656	+	492	WP_283294721.1	hypothetical protein	-
MQ085_RS08475 (MQ085_08465)	1822643..1822957	+	315	WP_283294722.1	hypothetical protein	-
MQ085_RS08480 (MQ085_08470)	1823362..1825236	+	1875	WP_045427621.1	PhoX family phosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1786419..1836439	50020

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-84)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10783.62 Da
• Isoelectric Point: 10.6993

>T239597 WP_015871319.1 NZ_CP094319:c1821636-1821355 [Edwardsiella anguillarum]
MTYKLSFEKRALKEWKKLAPPIQSQLKKKLIERLENPHVPAARLSGRANRYKIKLRSSGYRLVYEVNDSEIILLVIAIGK
RADNEVYQAADSR

Nucleotide

• Length: 282 bp

>T239597 NZ_LS483250:c764117-763830 [Moritella yayanosii]
ATGACCTATGAGTTAGAATTTAAAAAGTCAGCACTTAAAGAATGGAAAAAGTTAGGTGCGACGATTCAATCACAGTTTAA
GAAAAAGTTAACCGATATTTTAAGCAATCCACATATTGAAAGCGCCAAGCTATCTGGTGGTAACGAATTATATAAAATTA
AGCTTAGGCAAGTAGGTTATCGGTTAGTTTACGAAGTCAATGATACAGTAGTTACGGTCACCGTGATCTCTGTTGGAAAA
CGTGACAAAGGAAAAATATATACTGCTGCAATGAATCGCATCAACTAG

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9155.24 Da
• Isoelectric Point: 3.7550

>AT239597 WP_015871318.1 NZ_CP094319:c1821877-1821626 [Edwardsiella anguillarum]
MAYQILTTTAASITDLKRNPMGTIAEGDGNAVAILNRNEPAFYCVPPELYAYYLELAEDAALNRIADERLEDAEFVSVNI
DDL

Nucleotide

• Length: 252 bp

>AT239597 NZ_LS483250:c764355-764107 [Moritella yayanosii]
ATGACAACTAGAATATTAACTGAAGCAGCTGCAAGTATTAGCGAGCTTAAAGCAAACCCTATGAAAGTCGCATTGAGTGC
TCACGGAGAAGCTATTGCGGTATTAAATAGAAATGAACCTGCGTTTTATTGCATACCAGCAGATACTTATGAGTTTATGA
TGGATTACATTGAAGATTTAGAGCTACTTGCGATTGTTGAACAACGTAAAAATGAAGCAAGTGTAAAGGTTAGTTTAAAT
GACCTATGA

Structures

Toxin

• AlphaFold DB: C5BBL4

Antitoxin

• AlphaFold DB: C5BBL3