Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1116739..1117331 Replicon chromosome
Accession NZ_CP094319
Organism Edwardsiella anguillarum strain 43651

Toxin (Protein)


Gene name Hha Uniprot ID D0ZEC2
Locus tag MQ085_RS05080 Protein ID WP_012847872.1
Coordinates 1116739..1116942 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A034T4H2
Locus tag MQ085_RS05085 Protein ID WP_034163649.1
Coordinates 1116963..1117331 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MQ085_RS05060 (MQ085_05065) 1112027..1113739 - 1713 WP_174490643.1 hypothetical protein -
MQ085_RS05065 (MQ085_05070) 1113736..1114788 - 1053 WP_032082908.1 nucleoid-associated protein -
MQ085_RS05070 (MQ085_05075) 1115174..1115794 + 621 WP_001267012.1 recombinase family protein -
MQ085_RS05075 (MQ085_05080) 1116012..1116239 + 228 WP_024183738.1 DUF2188 domain-containing protein -
MQ085_RS05080 (MQ085_05085) 1116739..1116942 - 204 WP_012847872.1 HHA domain-containing protein Toxin
MQ085_RS05085 (MQ085_05090) 1116963..1117331 - 369 WP_034163649.1 Hha toxicity modulator TomB Antitoxin
MQ085_RS05090 (MQ085_05095) 1117698..1120850 - 3153 WP_034163648.1 efflux RND transporter permease subunit -
MQ085_RS05095 (MQ085_05100) 1120894..1122078 - 1185 WP_034163646.1 efflux RND transporter periplasmic adaptor subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-115)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8103.37 Da        Isoelectric Point: 5.0914

>T239595 WP_012847872.1 NZ_CP094319:c1116942-1116739 [Edwardsiella anguillarum]
MTKIDYLMKLRKCTTLDTLERVIEKNKYELSDDELEIFYSAADHRLAELTMNKLYDKIPAEVWQYVR

Download         Length: 204 bp

>T239595 NZ_LS399318:4280782-4280884 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14118.85 Da        Isoelectric Point: 6.2108

>AT239595 WP_034163649.1 NZ_CP094319:c1117331-1116963 [Edwardsiella anguillarum]
MDEYTSYQHDIAELKYLCDSLYHQGIDVLGESHHGWVSDPTAKVNLQLNELIEHIASVAQSFKIKYPRHSDLAEILDDYL
DETYALFGAYSVSETALRHWLRTKRRVAYCLAHEKRNAALHV

Download         Length: 369 bp

>AT239595 NZ_LS399318:c4280891-4280746 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A034SMG4

Antitoxin

Source ID Structure
AlphaFold DB A0A034T4H2

References