Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2738346..2738938 Replicon chromosome
Accession NZ_CP094317
Organism Edwardsiella anguillarum strain R17-63

Toxin (Protein)


Gene name Hha Uniprot ID D0ZEC2
Locus tag MQ083_RS12595 Protein ID WP_012847872.1
Coordinates 2738735..2738938 (+) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A034T4H2
Locus tag MQ083_RS12590 Protein ID WP_034163649.1
Coordinates 2738346..2738714 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MQ083_RS12580 (MQ083_12545) 2733599..2734783 + 1185 WP_034163646.1 efflux RND transporter periplasmic adaptor subunit -
MQ083_RS12585 (MQ083_12550) 2734827..2737979 + 3153 WP_034163648.1 efflux RND transporter permease subunit -
MQ083_RS12590 (MQ083_12555) 2738346..2738714 + 369 WP_034163649.1 Hha toxicity modulator TomB Antitoxin
MQ083_RS12595 (MQ083_12560) 2738735..2738938 + 204 WP_012847872.1 HHA domain-containing protein Toxin
MQ083_RS12605 (MQ083_12570) 2739439..2739768 + 330 WP_034163651.1 MGMT family protein -
MQ083_RS12610 (MQ083_12575) 2739877..2740743 + 867 WP_034163652.1 acyl-CoA thioesterase II -
MQ083_RS12615 (MQ083_12580) 2740778..2742058 - 1281 WP_034163814.1 ammonium transporter AmtB -
MQ083_RS12620 (MQ083_12585) 2742079..2742417 - 339 WP_034163654.1 P-II family nitrogen regulator -
MQ083_RS12625 (MQ083_12590) 2742695..2743156 - 462 WP_034163655.1 Lrp/AsnC family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-115)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8103.37 Da        Isoelectric Point: 5.0914

>T239592 WP_012847872.1 NZ_CP094317:2738735-2738938 [Edwardsiella anguillarum]
MTKIDYLMKLRKCTTLDTLERVIEKNKYELSDDELEIFYSAADHRLAELTMNKLYDKIPAEVWQYVR

Download         Length: 204 bp

>T239592 NZ_LS399318:2790645-2791013 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGTATTACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14118.85 Da        Isoelectric Point: 6.2108

>AT239592 WP_034163649.1 NZ_CP094317:2738346-2738714 [Edwardsiella anguillarum]
MDEYTSYQHDIAELKYLCDSLYHQGIDVLGESHHGWVSDPTAKVNLQLNELIEHIASVAQSFKIKYPRHSDLAEILDDYL
DETYALFGAYSVSETALRHWLRTKRRVAYCLAHEKRNAALHV

Download         Length: 369 bp

>AT239592 NZ_LS399318:2790427-2790648 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCTGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A034SMG4

Antitoxin

Source ID Structure
AlphaFold DB A0A034T4H2

References