Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DhiAT/dnstrm_HI1420(antitoxin)
Location 2016932..2017711 Replicon chromosome
Accession NZ_CP094317
Organism Edwardsiella anguillarum strain R17-63

Toxin (Protein)


Gene name dhiT Uniprot ID -
Locus tag MQ083_RS09025 Protein ID WP_198077053.1
Coordinates 2016932..2017189 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name dhiA Uniprot ID -
Locus tag MQ083_RS09030 Protein ID WP_283294710.1
Coordinates 2017199..2017711 (+) Length 171 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MQ083_RS08985 (MQ083_08975) 2012100..2012651 - 552 WP_081926439.1 putative peptidoglycan-binding domain-containing protein -
MQ083_RS08990 (MQ083_08980) 2012654..2012992 - 339 WP_283318441.1 phage holin, lambda family -
MQ083_RS08995 (MQ083_08985) 2013078..2013407 - 330 WP_034165091.1 type II toxin-antitoxin system RelE/ParE family toxin -
MQ083_RS09000 (MQ083_08990) 2013382..2013612 - 231 WP_034165090.1 ParD-like family protein -
MQ083_RS09005 (MQ083_08995) 2013729..2014127 - 399 WP_283318442.1 hypothetical protein -
MQ083_RS09010 (MQ083_09000) 2014361..2015179 - 819 WP_283318443.1 hypothetical protein -
MQ083_RS09015 (MQ083_09005) 2015254..2015559 - 306 WP_283318444.1 hypothetical protein -
MQ083_RS09020 (MQ083_09010) 2015792..2016562 - 771 WP_283294713.1 Rha family transcriptional regulator -
MQ083_RS09025 (MQ083_09015) 2016932..2017189 + 258 WP_198077053.1 DUF4160 domain-containing protein Toxin
MQ083_RS09030 (MQ083_09020) 2017199..2017711 + 513 WP_283294710.1 DUF2442 domain-containing protein Antitoxin
MQ083_RS09035 (MQ083_09025) 2018078..2018587 - 510 WP_071525693.1 hypothetical protein -
MQ083_RS09040 (MQ083_09030) 2018588..2019628 - 1041 WP_283318445.1 hypothetical protein -
MQ083_RS09045 (MQ083_09035) 2019773..2020072 - 300 WP_283318446.1 DUF1364 family protein -
MQ083_RS09050 (MQ083_09040) 2020075..2020719 - 645 WP_034165085.1 DUF1367 family protein -
MQ083_RS09055 (MQ083_09045) 2020829..2021176 - 348 WP_034165084.1 hypothetical protein -
MQ083_RS09060 (MQ083_09050) 2021204..2022454 - 1251 WP_283318447.1 DnaB-like helicase C-terminal domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1991083..2038691 47608


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF4160

(9-74)

Antitoxin

Uncharacterized protein HI1420

(82-161)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9625.29 Da        Isoelectric Point: 7.4665

>T239591 WP_198077053.1 NZ_CP094317:2016932-2017189 [Edwardsiella anguillarum]
MPEIDALMGLSFVMYFFDNQTHSLPHVHVKYGEFELVIGIDSGEALEGYLPPKKRKLAESHIKANKTRLLAMWQMAVNGM
HPGKL

Download         Length: 258 bp

>T239591 NZ_LS399318:c2383931-2383548 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGTACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGAAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin


Download         Length: 171 a.a.        Molecular weight: 18249.67 Da        Isoelectric Point: 7.3201

>AT239591 WP_283294710.1 NZ_CP094317:2017199-2017711 [Edwardsiella anguillarum]
MLKIIDVDVVGDHVIEVEFSDGFRGRADLTALFSKPPFSAIADFNRFSLTASGVLNWGDAELSADTVRRMSKGAVVSASS
RSLMPENVEAILRQATWESMSEGRPDILQAALRGYAEQLGHADVIKRAGIASRSSAYKTLSPSTNPSFKSLAKISGAILA
IVRENNAQHG

Download         Length: 513 bp

>AT239591 NZ_LS399318:c2384173-2383931 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References