Detailed information of TA system TA239591

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): DhiAT/dnstrm_HI1420(antitoxin)
• Location: 2016932..2017711
• Replicon: chromosome
• Accession: NZ_CP094317
• Organism: Edwardsiella anguillarum strain R17-63

Toxin (Protein)

• Gene name: dhiT
• Uniprot ID: -
• Locus tag: MQ083_RS09025
• Protein ID: WP_198077053.1
• Coordinates: 2016932..2017189 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: dhiA
• Uniprot ID: -
• Locus tag: MQ083_RS09030
• Protein ID: WP_283294710.1
• Coordinates: 2017199..2017711 (+)
• Length: 171 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MQ083_RS08985 (MQ083_08975)	2012100..2012651	-	552	WP_081926439.1	putative peptidoglycan-binding domain-containing protein	-
MQ083_RS08990 (MQ083_08980)	2012654..2012992	-	339	WP_283318441.1	phage holin, lambda family	-
MQ083_RS08995 (MQ083_08985)	2013078..2013407	-	330	WP_034165091.1	type II toxin-antitoxin system RelE/ParE family toxin	-
MQ083_RS09000 (MQ083_08990)	2013382..2013612	-	231	WP_034165090.1	ParD-like family protein	-
MQ083_RS09005 (MQ083_08995)	2013729..2014127	-	399	WP_283318442.1	hypothetical protein	-
MQ083_RS09010 (MQ083_09000)	2014361..2015179	-	819	WP_283318443.1	hypothetical protein	-
MQ083_RS09015 (MQ083_09005)	2015254..2015559	-	306	WP_283318444.1	hypothetical protein	-
MQ083_RS09020 (MQ083_09010)	2015792..2016562	-	771	WP_283294713.1	Rha family transcriptional regulator	-
MQ083_RS09025 (MQ083_09015)	2016932..2017189	+	258	WP_198077053.1	DUF4160 domain-containing protein	Toxin
MQ083_RS09030 (MQ083_09020)	2017199..2017711	+	513	WP_283294710.1	DUF2442 domain-containing protein	Antitoxin
MQ083_RS09035 (MQ083_09025)	2018078..2018587	-	510	WP_071525693.1	hypothetical protein	-
MQ083_RS09040 (MQ083_09030)	2018588..2019628	-	1041	WP_283318445.1	hypothetical protein	-
MQ083_RS09045 (MQ083_09035)	2019773..2020072	-	300	WP_283318446.1	DUF1364 family protein	-
MQ083_RS09050 (MQ083_09040)	2020075..2020719	-	645	WP_034165085.1	DUF1367 family protein	-
MQ083_RS09055 (MQ083_09045)	2020829..2021176	-	348	WP_034165084.1	hypothetical protein	-
MQ083_RS09060 (MQ083_09050)	2021204..2022454	-	1251	WP_283318447.1	DnaB-like helicase C-terminal domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1991083..2038691	47608

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF4160 (9-74)

Antitoxin

• Uncharacterized protein HI1420 (82-161)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9625.29 Da
• Isoelectric Point: 7.4665

>T239591 WP_198077053.1 NZ_CP094317:2016932-2017189 [Edwardsiella anguillarum]
MPEIDALMGLSFVMYFFDNQTHSLPHVHVKYGEFELVIGIDSGEALEGYLPPKKRKLAESHIKANKTRLLAMWQMAVNGM
HPGKL

Nucleotide

• Length: 258 bp

>T239591 NZ_LS399318:c2383931-2383548 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGTACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGAAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin

Protein

• Length: 171 a.a.
• Molecular weight: 18249.67 Da
• Isoelectric Point: 7.3201

>AT239591 WP_283294710.1 NZ_CP094317:2017199-2017711 [Edwardsiella anguillarum]
MLKIIDVDVVGDHVIEVEFSDGFRGRADLTALFSKPPFSAIADFNRFSLTASGVLNWGDAELSADTVRRMSKGAVVSASS
RSLMPENVEAILRQATWESMSEGRPDILQAALRGYAEQLGHADVIKRAGIASRSSAYKTLSPSTNPSFKSLAKISGAILA
IVRENNAQHG

Nucleotide

• Length: 513 bp

>AT239591 NZ_LS399318:c2384173-2383931 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA