Detailed information of TA system TA239580

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vagCD/VapC-VagC
• Location: 56416..57059
• Replicon: plasmid unnamed2
• Accession: NZ_CP094316
• Organism: Edwardsiella anguillarum strain Eco2417

Toxin (Protein)

• Gene name: vagD
• Uniprot ID: -
• Locus tag: MQ092_RS20100
• Protein ID: WP_283292435.1
• Coordinates: 56416..56832 (-)
• Length: 139 a.a.

Antitoxin (Protein)

• Gene name: vagC
• Uniprot ID: A0A6C0NE67
• Locus tag: MQ092_RS20105
• Protein ID: WP_008322219.1
• Coordinates: 56829..57059 (-)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MQ092_RS20080 (MQ092_20055)	52036..52836	+	801	WP_283292457.1	IS21-like element helper ATPase IstB	-
MQ092_RS20085 (MQ092_20060)	52893..53612	+	720	Protein_55	IS3 family transposase	-
MQ092_RS20090 (MQ092_20065)	53773..54795	-	1023	WP_283292440.1	DNA helicase UvrD	-
MQ092_RS20095 (MQ092_20070)	54780..56342	-	1563	WP_283292438.1	AAA family ATPase	-
MQ092_RS20100 (MQ092_20075)	56416..56832	-	417	WP_283292435.1	type II toxin-antitoxin system VapC family toxin	Toxin
MQ092_RS20105 (MQ092_20080)	56829..57059	-	231	WP_008322219.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
MQ092_RS20110 (MQ092_20085)	57375..58946	+	1572	WP_283292432.1	AAA family ATPase	-
MQ092_RS20115 (MQ092_20090)	58995..59864	-	870	WP_068872224.1	hypothetical protein	-
MQ092_RS20120 (MQ092_20095)	59866..60954	-	1089	WP_283292455.1	transcriptional repressor PifC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	papC / papD	1..91493	91493

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-129)

Antitoxin

• SpoVT-AbrB domain (7-50)

Sequences

Toxin

Protein

• Length: 139 a.a.
• Molecular weight: 15132.48 Da
• Isoelectric Point: 7.3236

>T239580 WP_283292435.1 NZ_CP094316:c56832-56416 [Edwardsiella anguillarum]
VNKTYMLDTNICSFIMREQPDVVLKHLEQAVLRGHRIVVSAITYSEMRFGATGPKASPRHVQLVDAFCARLDAILPWDRA
AVDATTEIKLSLRLAGTPIGPNDTAIAGHAIAAGAVLVTNNTREFERVPGLVLEDWVR

Nucleotide

• Length: 417 bp

>T239580 NZ_CP094316:c56832-56416 [Edwardsiella anguillarum]
GTGAACAAGACCTACATGCTGGACACCAATATCTGCTCATTCATCATGCGCGAGCAGCCGGATGTGGTACTGAAGCATCT
GGAGCAGGCGGTGCTGCGCGGTCACCGCATTGTGGTCTCGGCCATCACTTATTCTGAAATGCGCTTCGGGGCCACCGGCC
CGAAAGCCTCGCCGCGCCACGTTCAGCTGGTCGACGCGTTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGCT
GCGGTGGACGCCACCACGGAGATTAAGCTGTCACTGCGCCTCGCCGGGACGCCGATCGGCCCGAACGACACGGCGATTGC
CGGGCATGCCATCGCCGCCGGTGCCGTGCTGGTGACGAATAATACGCGGGAATTTGAGCGGGTACCGGGTCTTGTGCTGG
AAGACTGGGTAAGATAA

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 8736.84 Da
• Isoelectric Point: 4.4692

>AT239580 WP_008322219.1 NZ_CP094316:c57059-56829 [Edwardsiella anguillarum]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFAQLEKADPDFMAEREDVVTDEGRFNL

Nucleotide

• Length: 231 bp

>AT239580 NZ_CP094316:c57059-56829 [Edwardsiella anguillarum]
ATGAGAACCGTATCGATATTTAAAAATGGCAATAACCGCGCCATCCGTCTGCCCCGCGATCTGGATTTTGAGGGGGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGTATCATCCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTCG
AAAAAGCTGACCCGGACTTTATGGCGGAGCGCGAGGACGTTGTCACCGACGAAGGACGATTTAACCTGTGA

Structures

Antitoxin

• AlphaFold DB: A0A6C0NE67