Detailed information of TA system TA239579

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 8861..9486
• Replicon: plasmid unnamed2
• Accession: NZ_CP094316
• Organism: Edwardsiella anguillarum strain Eco2417

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: MQ092_RS19850
• Protein ID: WP_098142458.1
• Coordinates: 8861..9259 (-)
• Length: 133 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: MQ092_RS19855
• Protein ID: WP_098142459.1
• Coordinates: 9259..9486 (-)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MQ092_RS19840 (MQ092_19815)	5996..6493	+	498	WP_283292378.1	hypothetical protein	-
MQ092_RS19845 (MQ092_19820)	6672..8783	+	2112	WP_283340759.1	type IV conjugative transfer system coupling protein TraD	-
MQ092_RS19850 (MQ092_19825)	8861..9259	-	399	WP_098142458.1	tRNA(fMet)-specific endonuclease VapC	Toxin
MQ092_RS19855 (MQ092_19830)	9259..9486	-	228	WP_098142459.1	toxin-antitoxin system antitoxin VapB	Antitoxin

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	papC / papD	1..91493	91493

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-125)

Antitoxin

• SpoVT-AbrB domain (7-53)

Sequences

Toxin

Protein

• Length: 133 a.a.
• Molecular weight: 14835.08 Da
• Isoelectric Point: 7.9270

>T239579 WP_098142458.1 NZ_CP094316:c9259-8861 [Edwardsiella anguillarum]
MLKYMLDTNICIFTLKNRPAQVRDKFNLHHNQMCISSITLMELIYGAEKSQSPEHNLAVIEGFIARLTVLNYDAPAAAHS
GQLRAEQARLGQPIGPYDQMIAGHARSQGLILVTNNTREFARVSGLRIEDWV

Nucleotide

• Length: 399 bp

>T239579 NZ_LS398589:1607201-1607452 [Bordetella pertussis]
ATTGGAGGCGCGGCGACAAAAAAGCCGGGACAAAAGCGTCGCGCCGGGGCGGCGGCGCTGGGGCTGGATTTCAGCGCCAT
GGTCGAAATCGTGCTTGCATTGACACCGCGGGATTTCCACAAAAGCATGACTACCCATGCCGACCATCGCATTTGGCAGG
ACGTCTATTGCCCGGTGACAGCGATGGGCGCCGTCTACCTGAAGCTGACGGTCCTCGACGGCGTGCCGATCGTGTCGTTC
AAGGAGTTGTGA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8384.40 Da
• Isoelectric Point: 4.7405

>AT239579 WP_098142459.1 NZ_CP094316:c9486-9259 [Edwardsiella anguillarum]
METTVFLSNRSQAVRLPKAVALPSDVKRVDIVAVGRTRIITPAGESWDSWFEGEGVSTDFMASREQPKGQEREDF

Nucleotide

• Length: 228 bp

>AT239579 NZ_LS398589:1607455-1607856 [Bordetella pertussis]
ATGAAGTGTCCCGTATGCGGAGCGGCCGCGCTGGCGCGTGATACTCGCGATGTGCCCTATAGCTACAAGGGCGAGACCAT
CACGATTGCGGCGGTGACGGGCGACTGGTGTCCGGCATGCGGCGAGAACGTGCTCGATGGCGCTGAATCGGCGCGGGTGA
GCGAGGCCATGCTGGCTTTCAACCGCCTGGTCAACGCCCGCCGCGTCGACCCCGGGTTCATCGTGCGGGTGCGCAGGAAG
CTGGGGCTGGACCAGCGCGAAGCCGCGGCGCTGTTCGGCGGCGGCACCAATGCGTTCTCGCGTTACGAGAACGGCAAGAC
GCGCCCGCCGCTGGCGCTGGTGAAGCTGCTCAGGCTGCTGGATCGCCATCCGGAGCTGCTGGAGGAAGTCCGTGCGGATT
GA