Detailed information of TA system TA239578

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 3588579..3589242
• Replicon: chromosome
• Accession: NZ_CP094315
• Organism: Edwardsiella anguillarum strain Eco2417

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: MQ092_RS16815
• Protein ID: WP_034164690.1
• Coordinates: 3588579..3588995 (-)
• Length: 139 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: D0ZDY6
• Locus tag: MQ092_RS16820
• Protein ID: WP_012849755.1
• Coordinates: 3588976..3589242 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MQ092_RS16795 (MQ092_16770)	3584509..3586242	-	1734	WP_034164685.1	single-stranded-DNA-specific exonuclease RecJ	-
MQ092_RS16800 (MQ092_16775)	3586247..3586963	-	717	WP_034164686.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
MQ092_RS16805 (MQ092_16780)	3586991..3587890	-	900	WP_034164688.1	site-specific tyrosine recombinase XerD	-
MQ092_RS16810 (MQ092_16785)	3588042..3588554	+	513	WP_034164689.1	flavodoxin FldB	-
MQ092_RS16815 (MQ092_16790)	3588579..3588995	-	417	WP_034164690.1	protein YgfX	Toxin
MQ092_RS16820 (MQ092_16795)	3588976..3589242	-	267	WP_012849755.1	FAD assembly factor SdhE	Antitoxin
MQ092_RS16825 (MQ092_16800)	3589591..3590589	+	999	WP_034164692.1	tRNA-modifying protein YgfZ	-
MQ092_RS16830 (MQ092_16805)	3590631..3591455	-	825	WP_034164693.1	shikimate 5-dehydrogenase	-
MQ092_RS16835 (MQ092_16810)	3591612..3592484	-	873	WP_034164695.1	nucleoside-specific channel-forming protein Tsx	-
MQ092_RS16840 (MQ092_16815)	3593093..3593743	+	651	WP_034164746.1	hemolysin III family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-131)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 139 a.a.
• Molecular weight: 16229.03 Da
• Isoelectric Point: 11.6049

>T239578 WP_034164690.1 NZ_CP094315:c3588995-3588579 [Edwardsiella anguillarum]
VVLWRCNVHVSWRTQVMFLLGHGALVLAILLAPWPENYSAFWLVLLVAVIFECIRSQRRIARNRGELQLLTPQVWHWQLR
EWRLARRPWVSDLGALLILQSTHGVPCRRRLWLAADSMSREEWGQLRRALLDTGDDRA

Nucleotide

• Length: 417 bp

>T239578 NZ_LS398588:c2773284-2771944 [Bordetella pertussis]
ATGGGGCGCCGATCGCACAGCCGCAGCCTGTCCATCTGGACCAACGGCGTTCGCGTCGGGCGTTGGACGGTTCCCGCTCG
CGGAGAGATGGAACTGCAGTACGACGTGGATTGGGTCCGTGCCGACGTCGGCCGGCCACTTTCGCTGTCGCTGCCATTCA
ACTTGCAGAATCTGCCCCTCAAGGGGGAGAGAGTCGCCAACTACTTCGACAATCTGCTACCGGACAGCGACGCTATCCGT
CGTCGCGTGGCCGAGCGATTCAGGACGGGCTCGGTCGATCCCTTCGATCTGTTGAAAGCCATTGGACGCGATTGCGTTGG
CGCCGTACAGATCCTGGAAGACGAAGAGATACCTGAGGGCTTTGATCGCATCGAGGGCGTGCCTCTGTCCGAGGAGGACA
TCGAGCGGCATTTGATCGAAACCGTTACGCCGCGCGCCTTCGCTGCGGGCCGGGACCCGGACGCGGATTTCAGAATTTCT
CTGGCCGGCGCGCAAGAGAAGACAGCCTTCCTGTGGTGGGGCGGACAGTGGCTTGCGCCGCGTGGCGCGACATCGACGAG
CCATATTTTCAAACTTCCATTGGGCTTGGTGGGTGGACGGCGGGCTGACTTCAGCACTTCTGTTGATAACGAATGGCTGT
GTCTGAAGCTGCTGAAGGCGTATGGGTTGGATGTGGCTGAGGCCAGCATCGCAACCTTCGGACAGCAGCGAGTGCTGGTG
GTCGAGCGATTCGACCGGCGTGTTGCGCCCAACGGGCAATGGCTGATGCGCCTGCCGCAGGAAGATTTCTGCCAGGTCGA
GGGGTGCTCGCCGCTACGCAAGTATGAAAACGAGGGCGGCCCAGGACTCAAGGCCTTATTCGCCACGCTGCGGCAGTCAG
TGAACGCAGCGGTCGATATGAGAACGTTGATGGCGGCGCAGATCCTGTTTTGGTTGCTGCGGGCACCCGATGGCCACGCC
AAGAATTTCAGCATCCAGTTGTTGCCGCGCGGCCGTTTCCAGTTGACTAGACTGTACGACGTGATGTCGGCCTATCCGGT
ACTGGGCGATGGCGCGAATCAGTGGTCGCCGTTCGAAATCAAATTGGCGATGGCATTGATTGGCAAGAACCGGCATTACG
AGATGCACGGCATCCAGCGCAGGCACTTCAACAGCACCGCACAAAAAGTTGGTTATGGCCCGACGGCGGAGCCGATCATT
GAAGACCTGTTGGCCCGTACGCCCGCGATCATTGCCGCCGTGCAGGCCGATTTGCCGCAGGACTTCTCGCCGCGTGTTGC
GGACTCCGTCCTGGGTGGGCTTGCGCAGGCCGCAAAGTCGCTCGGCGCAATGATGCCGTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10318.90 Da
• Isoelectric Point: 5.6951

>AT239578 WP_012849755.1 NZ_CP094315:c3589242-3588976 [Edwardsiella anguillarum]
MDINNKARVHWACRRGMRELDIAIMPFFEHEYDALNDADKQTFVRLLACDDPELFKWLMNQGKPDDADLARMITLIQTRN
KERGPLAL

Nucleotide

• Length: 267 bp

>AT239578 NZ_LS398588:c2773543-2773286 [Bordetella pertussis]
ATGCCGCCGCCATCACAACCTCTGCTCACTACCGGCCAGCTTGGCGCGGTCTTGCAGGCTGCACGCAAAGCACAGGGACT
GACTCAATCGGCCCTGGCCAGTCGTATCGGCCTGAGCCAATCGCGGGTCTCGCACCTGGAGTTGAATGCCCATCAACTGA
GCGTGGAGCAGCTCCTGGCCTGGTGCGCGGCGCTAGGGTTGGAGTTGACGATTGCGACTCGCGGAAGTCCCGCAGGGTCT
TCCGACGCGGATTGGTGA

Structures

Antitoxin

• AlphaFold DB: A0A034T2Q8