Detailed information of TA system TA239569

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-DnaT
• Location: 1901533..1902055
• Replicon: chromosome
• Accession: NZ_CP094315
• Organism: Edwardsiella anguillarum strain Eco2417

Toxin (Protein)

• Gene name: relE
• Uniprot ID: C5BBL4
• Locus tag: MQ092_RS09025
• Protein ID: WP_015871319.1
• Coordinates: 1901533..1901814 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: C5BBL3
• Locus tag: MQ092_RS09030
• Protein ID: WP_015871318.1
• Coordinates: 1901804..1902055 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MQ092_RS09005 (MQ092_08995)	1896934..1897152	+	219	WP_225865175.1	hypothetical protein	-
MQ092_RS09010 (MQ092_09000)	1897314..1897709	+	396	WP_225865176.1	hypothetical protein	-
MQ092_RS09015 (MQ092_09005)	1897702..1899363	+	1662	WP_049703944.1	terminase	-
MQ092_RS09020 (MQ092_09015)	1899360..1901461	+	2102	Protein_1731	portal protein	-
MQ092_RS09025 (MQ092_09020)	1901533..1901814	-	282	WP_015871319.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
MQ092_RS09030 (MQ092_09025)	1901804..1902055	-	252	WP_015871318.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
MQ092_RS09035 (MQ092_09030)	1902343..1902834	+	492	WP_225865179.1	hypothetical protein	-
MQ092_RS09040 (MQ092_09035)	1902821..1903168	+	348	WP_144242832.1	hypothetical protein	-
MQ092_RS09045 (MQ092_09040)	1903540..1905414	+	1875	WP_034165826.1	PhoX family phosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1868839..1916165	47326

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-84)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10783.62 Da
• Isoelectric Point: 10.6993

>T239569 WP_015871319.1 NZ_CP094315:c1901814-1901533 [Edwardsiella anguillarum]
MTYKLSFEKRALKEWKKLAPPIQSQLKKKLIERLENPHVPAARLSGRANRYKIKLRSSGYRLVYEVNDSEIILLVIAIGK
RADNEVYQAADSR

Nucleotide

• Length: 282 bp

>T239569 NZ_LR962863:2451991-2452257 [Staphylococcus schleiferi]
ATGAGTTATTACAGCGTCTTGATTAAAAATTCAGCTAAAAGTGATTTGAAAAAAATCAACAAATCGCACCTCAAAGAACA
ATTTTTAAATGTTGTTGAAACTTTAAAAATTGATCCTTATGAACCTAGTCAATCTTTTGAAAAGTTACAACCAAAGCATT
TAGGACGTTATTCAAGACGTATTAATCATCAGCATAGAGTTGTTTATACGGTTGATGATGAAAAGAGAGAGGTTTATATA
TTTTCTACTTGGTCGCATTATGAGTAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9155.24 Da
• Isoelectric Point: 3.7550

>AT239569 WP_015871318.1 NZ_CP094315:c1902055-1901804 [Edwardsiella anguillarum]
MAYQILTTTAASITDLKRNPMGTIAEGDGNAVAILNRNEPAFYCVPPELYAYYLELAEDAALNRIADERLEDAEFVSVNI
DDL

Nucleotide

• Length: 252 bp

>AT239569 NZ_LR962863:2451734-2451991 [Staphylococcus schleiferi]
ATGAATATCAAAACACCTACAAATGCCAGAAAAGAATTTTATGAATTATTAAAACATGTAAATGTTAATCATGAGCCAGT
TATTATAAGTGGTTCTAAAAGTGAAAATAACGCAGTTATTGTAAGTCAAAAAGATTGGAATAGTATTCAAGAAACGTTGT
TTCTTGAATCAACTGGCACTATGGATAAAGTGAGAAAACGTGAAAAGGATGATAGTGGTTATACAAATATTGAAGATTTA
GATTGGGGTAACTTGTAA

Structures

Toxin

• AlphaFold DB: C5BBL4

Antitoxin

• AlphaFold DB: C5BBL3