Detailed information of TA system TA239567

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vagCD/VapC-VagC
• Location: 53133..53776
• Replicon: plasmid unnamed6
• Accession: NZ_CP094314
• Organism: Edwardsiella anguillarum strain R18-14-16

Toxin (Protein)

• Gene name: vagD
• Uniprot ID: -
• Locus tag: MQ086_RS19795
• Protein ID: WP_283292435.1
• Coordinates: 53133..53549 (-)
• Length: 139 a.a.

Antitoxin (Protein)

• Gene name: vagC
• Uniprot ID: A0A6C0NE67
• Locus tag: MQ086_RS19800
• Protein ID: WP_008322219.1
• Coordinates: 53546..53776 (-)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MQ086_RS19775 (MQ086_19750)	48753..49553	+	801	WP_283292457.1	IS21-like element helper ATPase IstB	-
MQ086_RS19780 (MQ086_19755)	49610..50329	+	720	Protein_51	IS3 family transposase	-
MQ086_RS19785 (MQ086_19760)	50490..51512	-	1023	WP_283292440.1	DNA helicase UvrD	-
MQ086_RS19790 (MQ086_19765)	51497..53059	-	1563	WP_283292438.1	AAA family ATPase	-
MQ086_RS19795 (MQ086_19770)	53133..53549	-	417	WP_283292435.1	type II toxin-antitoxin system VapC family toxin	Toxin
MQ086_RS19800 (MQ086_19775)	53546..53776	-	231	WP_008322219.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
MQ086_RS19805 (MQ086_19780)	54092..55663	+	1572	WP_283292432.1	AAA family ATPase	-
MQ086_RS19810 (MQ086_19785)	55712..56581	-	870	WP_068872224.1	hypothetical protein	-
MQ086_RS19815 (MQ086_19790)	56583..57671	-	1089	WP_283292455.1	transcriptional repressor PifC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	papC / papD	1..91497	91497

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-129)

Antitoxin

• SpoVT-AbrB domain (7-50)

Sequences

Toxin

Protein

• Length: 139 a.a.
• Molecular weight: 15132.48 Da
• Isoelectric Point: 7.3236

>T239567 WP_283292435.1 NZ_CP094314:c53549-53133 [Edwardsiella anguillarum]
VNKTYMLDTNICSFIMREQPDVVLKHLEQAVLRGHRIVVSAITYSEMRFGATGPKASPRHVQLVDAFCARLDAILPWDRA
AVDATTEIKLSLRLAGTPIGPNDTAIAGHAIAAGAVLVTNNTREFERVPGLVLEDWVR

Nucleotide

• Length: 417 bp

>T239567 NZ_LR962863:851637-851990 [Staphylococcus schleiferi]
ATGAAGCGCGGGGACGTTTACTTAGCAGATTTATCACCAGTACAGGGCTCTGAACAGGGGGGAGTAAGGCCCGTAGTTAT
TATTCAGAATGACACTGGAAATAAATACAGTCCAACTGTTATTGTCGCAGCAATTACTGGTCGGATTAATAAAGCTAAAA
TACCAACGCATGTAGAAATAGAAAAAAATAAATATAAGCTCGACAAAGATTCTGTCATCTTATTAGAACAAATTCGAACG
GTCGATAAGAAGAGACTTAAAGAGAAATTAACATTTTTATCTGAAGAAAAGATGAAAGAAGTTAATTACGCACTTGGTAT
TAGTTTAGGACTGAACATGAATCATCATAAATAG

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 8736.84 Da
• Isoelectric Point: 4.4692

>AT239567 WP_008322219.1 NZ_CP094314:c53776-53546 [Edwardsiella anguillarum]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFAQLEKADPDFMAEREDVVTDEGRFNL

Nucleotide

• Length: 231 bp

>AT239567 NZ_LR962863:851466-851636 [Staphylococcus schleiferi]
ATGTCAGCATTCAATCAAACAAGATTTAAAAATTTAGAACAATCTTTAAAAGAAGGCTATGTTCAAATGGCAGATTTGAA
TCTCTCCCTAGCAACTGAAGCATATTCAGTTGAATGTGAAGCCTGTGATTGTAATGAATCACACTTGTTATCAGATTATA
AGGATGACTAA

Structures

Antitoxin

• AlphaFold DB: A0A6C0NE67