Detailed information of TA system TA239565

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 3545226..3545889
• Replicon: chromosome
• Accession: NZ_CP094313
• Organism: Edwardsiella anguillarum strain R18-14-16

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: MQ086_RS16525
• Protein ID: WP_034164690.1
• Coordinates: 3545226..3545642 (-)
• Length: 139 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: D0ZDY6
• Locus tag: MQ086_RS16530
• Protein ID: WP_012849755.1
• Coordinates: 3545623..3545889 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MQ086_RS16505 (MQ086_16480)	3541156..3542889	-	1734	WP_034164685.1	single-stranded-DNA-specific exonuclease RecJ	-
MQ086_RS16510 (MQ086_16485)	3542894..3543610	-	717	WP_034164686.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
MQ086_RS16515 (MQ086_16490)	3543638..3544537	-	900	WP_034164688.1	site-specific tyrosine recombinase XerD	-
MQ086_RS16520 (MQ086_16495)	3544689..3545201	+	513	WP_034164689.1	flavodoxin FldB	-
MQ086_RS16525 (MQ086_16500)	3545226..3545642	-	417	WP_034164690.1	protein YgfX	Toxin
MQ086_RS16530 (MQ086_16505)	3545623..3545889	-	267	WP_012849755.1	FAD assembly factor SdhE	Antitoxin
MQ086_RS16535 (MQ086_16510)	3546238..3547236	+	999	WP_034164692.1	tRNA-modifying protein YgfZ	-
MQ086_RS16540 (MQ086_16515)	3547278..3548102	-	825	WP_034164693.1	shikimate 5-dehydrogenase	-
MQ086_RS16545 (MQ086_16520)	3548259..3549131	-	873	WP_034164695.1	nucleoside-specific channel-forming protein Tsx	-
MQ086_RS16550 (MQ086_16525)	3549740..3550390	+	651	WP_034164746.1	hemolysin III family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-131)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 139 a.a.
• Molecular weight: 16229.03 Da
• Isoelectric Point: 11.6049

>T239565 WP_034164690.1 NZ_CP094313:c3545642-3545226 [Edwardsiella anguillarum]
VVLWRCNVHVSWRTQVMFLLGHGALVLAILLAPWPENYSAFWLVLLVAVIFECIRSQRRIARNRGELQLLTPQVWHWQLR
EWRLARRPWVSDLGALLILQSTHGVPCRRRLWLAADSMSREEWGQLRRALLDTGDDRA

Nucleotide

• Length: 417 bp

>T239565 NZ_LR898876:2038-2319 [Escherichia coli]
ATGATGGAGATATTCTGGACCATACTGGCCAGCCAGGACAGGAAGCGCATTCGTGAGTATATTGCGGAGCAGAACCTGAT
GGCTGCCATTGAACTGGACGAACGGATTGGTTATTCAGCCAGCAGCCTGGCCGGGCAGCCGTATAAAGGCCGCAACGGTC
GTGTGGAAGGTACCCGGGAACTGGTTATTCACCCGCATTTTGTTCTGGTTTATGAGGTCGACAGCCAGTGGGGAAAAGTG
TATATCCTGCGAGTATTGCATACTGCACAGAAGTGGCCATAG

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10318.90 Da
• Isoelectric Point: 5.6951

>AT239565 WP_012849755.1 NZ_CP094313:c3545889-3545623 [Edwardsiella anguillarum]
MDINNKARVHWACRRGMRELDIAIMPFFEHEYDALNDADKQTFVRLLACDDPELFKWLMNQGKPDDADLARMITLIQTRN
KERGPLAL

Nucleotide

• Length: 267 bp

>AT239565 NZ_LR898876:1772-2041 [Escherichia coli]
ATGGCACAGGTTAATATGAGTTTAAGAATCGACGCTGAACTGAAGGATGCTTTTATGGCCGCTGCAAAAAGCATGGACCG
TAATGGCTCTCAGTTAATTCGGGATTTTATGCGCCAGACCGTTGAACGGCAGCATAATACTTGGTTCCGTGACCAGGTTG
CGGCAGGACGTCAGCAACTCGAACGCGGCGATGTGCTTCCCCATGATATGGTCGAATCCTCCGCTACTGCATGGCGGGAT
GAAATAAGCAGGAAGGTCGCCGGTAAATGA

Structures

Antitoxin

• AlphaFold DB: A0A034T2Q8