Detailed information of TA system TA239552

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 3588604..3589267
• Replicon: chromosome
• Accession: NZ_CP094311
• Organism: Edwardsiella anguillarum strain R18-14-2

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: MQ082_RS16805
• Protein ID: WP_034164690.1
• Coordinates: 3588604..3589020 (-)
• Length: 139 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: D0ZDY6
• Locus tag: MQ082_RS16810
• Protein ID: WP_012849755.1
• Coordinates: 3589001..3589267 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MQ082_RS16785 (MQ082_16760)	3584534..3586267	-	1734	WP_034164685.1	single-stranded-DNA-specific exonuclease RecJ	-
MQ082_RS16790 (MQ082_16765)	3586272..3586988	-	717	WP_034164686.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
MQ082_RS16795 (MQ082_16770)	3587016..3587915	-	900	WP_034164688.1	site-specific tyrosine recombinase XerD	-
MQ082_RS16800 (MQ082_16775)	3588067..3588579	+	513	WP_034164689.1	flavodoxin FldB	-
MQ082_RS16805 (MQ082_16780)	3588604..3589020	-	417	WP_034164690.1	protein YgfX	Toxin
MQ082_RS16810 (MQ082_16785)	3589001..3589267	-	267	WP_012849755.1	FAD assembly factor SdhE	Antitoxin
MQ082_RS16815 (MQ082_16790)	3589616..3590614	+	999	WP_034164692.1	tRNA-modifying protein YgfZ	-
MQ082_RS16820 (MQ082_16795)	3590656..3591480	-	825	WP_034164693.1	shikimate 5-dehydrogenase	-
MQ082_RS16825 (MQ082_16800)	3591637..3592509	-	873	WP_034164695.1	nucleoside-specific channel-forming protein Tsx	-
MQ082_RS16830 (MQ082_16805)	3593118..3593768	+	651	WP_034164746.1	hemolysin III family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-131)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 139 a.a.
• Molecular weight: 16229.03 Da
• Isoelectric Point: 11.6049

>T239552 WP_034164690.1 NZ_CP094311:c3589020-3588604 [Edwardsiella anguillarum]
VVLWRCNVHVSWRTQVMFLLGHGALVLAILLAPWPENYSAFWLVLLVAVIFECIRSQRRIARNRGELQLLTPQVWHWQLR
EWRLARRPWVSDLGALLILQSTHGVPCRRRLWLAADSMSREEWGQLRRALLDTGDDRA

Nucleotide

• Length: 417 bp

>T239552 NZ_LR898874:c3218471-3218220 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10318.90 Da
• Isoelectric Point: 5.6951

>AT239552 WP_012849755.1 NZ_CP094311:c3589267-3589001 [Edwardsiella anguillarum]
MDINNKARVHWACRRGMRELDIAIMPFFEHEYDALNDADKQTFVRLLACDDPELFKWLMNQGKPDDADLARMITLIQTRN
KERGPLAL

Nucleotide

• Length: 267 bp

>AT239552 NZ_LR898874:c3218223-3217969 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAACCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGATCACCGTCTGGTATACGCGGTTACTGATGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Structures

Antitoxin

• AlphaFold DB: A0A034T2Q8