Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 2125975..2126570 Replicon chromosome
Accession NC_012912
Organism Dickeya zeae Ech1591

Toxin (Protein)


Gene name doc Uniprot ID C6CGE1
Locus tag DD1591_RS09290 Protein ID WP_012769580.1
Coordinates 2126193..2126570 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID C6CGE0
Locus tag DD1591_RS09285 Protein ID WP_012769579.1
Coordinates 2125975..2126196 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DD1591_RS09265 2121355..2122917 + 1563 WP_012769575.1 nitrate reductase subunit beta -
DD1591_RS09270 2122914..2123633 + 720 WP_012769576.1 nitrate reductase molybdenum cofactor assembly chaperone -
DD1591_RS09275 2123633..2124310 + 678 WP_012769577.1 respiratory nitrate reductase subunit gamma -
DD1591_RS09280 2124684..2125832 + 1149 WP_012769578.1 L-threonine dehydrogenase -
DD1591_RS09285 2125975..2126196 + 222 WP_012769579.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
DD1591_RS09290 2126193..2126570 + 378 WP_012769580.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
DD1591_RS09295 2126974..2127621 + 648 WP_012769581.1 EcsC family protein -
DD1591_RS09300 2127731..2128762 - 1032 WP_012769582.1 methionine synthase -
DD1591_RS09305 2128790..2129767 - 978 WP_012769583.1 DUF1852 domain-containing protein -
DD1591_RS09310 2130225..2130455 - 231 WP_012769584.1 tautomerase PptA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(5-120)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-52)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14324.37 Da        Isoelectric Point: 5.1976

>T23955 WP_012769580.1 NC_012912:2126193-2126570 [Dickeya chrysanthemi Ech1591]
MKWVSAQDVIDFHDRILQVLPGVTGMADPGRAEALIYRVQNRLYYEGVTELFELAATYWVTIARGHIFNDGNKRTAFFVT
MTFLRRNGILIVDNDNSLEELTIKAATGEYLVSELAEQLRQRVEK

Download         Length: 378 bp

>T23955 NC_012912:2126193-2126570 [Dickeya chrysanthemi Ech1591]
ATGAAATGGGTGAGTGCGCAGGACGTCATTGACTTTCATGATCGTATTTTGCAGGTGTTGCCTGGTGTGACGGGTATGGC
TGATCCTGGTCGGGCTGAGGCGTTGATTTATCGAGTACAAAACCGTCTTTATTATGAAGGTGTGACCGAACTGTTTGAGT
TGGCGGCGACGTATTGGGTAACTATTGCTCGTGGTCATATTTTTAATGATGGCAATAAACGCACTGCTTTTTTTGTTACC
ATGACATTTTTGCGCCGCAATGGCATATTGATTGTCGATAACGATAATTCGCTGGAAGAACTCACCATTAAGGCGGCAAC
CGGAGAATACCTGGTATCGGAGCTCGCCGAACAATTAAGACAACGGGTAGAAAAATAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8180.26 Da        Isoelectric Point: 6.4621

>AT23955 WP_012769579.1 NC_012912:2125975-2126196 [Dickeya chrysanthemi Ech1591]
MKTYTITEARQNIATVIDTAASGEPVEITRRDGTSAVLIPKAEFEAYQKARLDAEFDFIMQRHGHTLKALADR

Download         Length: 222 bp

>AT23955 NC_012912:2125975-2126196 [Dickeya chrysanthemi Ech1591]
ATGAAAACGTATACCATTACTGAAGCCCGGCAAAACATTGCAACGGTGATTGATACGGCGGCTAGCGGTGAGCCGGTAGA
GATTACGCGTCGGGATGGCACCTCGGCTGTACTTATCCCCAAAGCGGAGTTTGAGGCTTATCAGAAAGCCAGATTAGACG
CTGAATTTGATTTCATCATGCAGCGGCACGGACACACCCTCAAAGCGCTCGCCGACAGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB C6CGE1

Antitoxin

Source ID Structure
AlphaFold DB C6CGE0

References