Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1168751..1169343 Replicon chromosome
Accession NZ_CP094311
Organism Edwardsiella anguillarum strain R18-14-2

Toxin (Protein)


Gene name Hha Uniprot ID D0ZEC2
Locus tag MQ082_RS05430 Protein ID WP_012847872.1
Coordinates 1168751..1168954 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A034T4H2
Locus tag MQ082_RS05435 Protein ID WP_034163649.1
Coordinates 1168975..1169343 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MQ082_RS05400 (MQ082_05400) 1164547..1165008 + 462 WP_034163655.1 Lrp/AsnC family transcriptional regulator -
MQ082_RS05405 (MQ082_05405) 1165286..1165624 + 339 WP_034163654.1 P-II family nitrogen regulator -
MQ082_RS05410 (MQ082_05410) 1165645..1166925 + 1281 WP_034163814.1 ammonium transporter AmtB -
MQ082_RS05415 (MQ082_05415) 1166960..1167826 - 867 WP_034163652.1 acyl-CoA thioesterase II -
MQ082_RS05420 (MQ082_05420) 1167935..1168264 - 330 WP_034163651.1 MGMT family protein -
MQ082_RS05430 (MQ082_05430) 1168751..1168954 - 204 WP_012847872.1 HHA domain-containing protein Toxin
MQ082_RS05435 (MQ082_05435) 1168975..1169343 - 369 WP_034163649.1 Hha toxicity modulator TomB Antitoxin
MQ082_RS05440 (MQ082_05440) 1169710..1172862 - 3153 WP_034163648.1 efflux RND transporter permease subunit -
MQ082_RS05445 (MQ082_05445) 1172906..1174090 - 1185 WP_034163646.1 efflux RND transporter periplasmic adaptor subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-115)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8103.37 Da        Isoelectric Point: 5.0914

>T239542 WP_012847872.1 NZ_CP094311:c1168954-1168751 [Edwardsiella anguillarum]
MTKIDYLMKLRKCTTLDTLERVIEKNKYELSDDELEIFYSAADHRLAELTMNKLYDKIPAEVWQYVR

Download         Length: 204 bp

>T239542 NZ_LR898874:1141036-1141371 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCCGG
ACATCGTCCGGCTGTTGTCCTCAGTCCGTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTTGAAGTTGTTCTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGA
ATCGCCTGGCGGGCAAGAGGAGTAACGAAGAAAGGAACGGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTGCTGATTGGCTAG

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14118.85 Da        Isoelectric Point: 6.2108

>AT239542 WP_034163649.1 NZ_CP094311:c1169343-1168975 [Edwardsiella anguillarum]
MDEYTSYQHDIAELKYLCDSLYHQGIDVLGESHHGWVSDPTAKVNLQLNELIEHIASVAQSFKIKYPRHSDLAEILDDYL
DETYALFGAYSVSETALRHWLRTKRRVAYCLAHEKRNAALHV

Download         Length: 369 bp

>AT239542 NZ_LR898874:1140788-1141036 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCTCCTGCAGTGCGGATCCCAGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTACGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAGCGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGGGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A034SMG4

Antitoxin

Source ID Structure
AlphaFold DB A0A034T4H2

References