Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 1694872..1695425 Replicon chromosome
Accession NC_012912
Organism Dickeya zeae Ech1591

Toxin (Protein)


Gene name ccdB Uniprot ID C6CEY2
Locus tag DD1591_RS07380 Protein ID WP_012769208.1
Coordinates 1695111..1695425 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID C6CEY1
Locus tag DD1591_RS07375 Protein ID WP_012769207.1
Coordinates 1694872..1695108 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DD1591_RS07360 1690321..1691556 - 1236 WP_012769204.1 DNA cytosine methyltransferase -
DD1591_RS07365 1691841..1692863 + 1023 WP_012769205.1 DUF4917 family protein -
DD1591_RS07370 1693607..1694551 + 945 WP_012769206.1 DUF1738 domain-containing protein -
DD1591_RS07375 1694872..1695108 + 237 WP_012769207.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
DD1591_RS07380 1695111..1695425 + 315 WP_012769208.1 CcdB family protein Toxin
DD1591_RS07385 1695443..1696174 - 732 WP_012769209.1 hypothetical protein -
DD1591_RS07390 1696183..1697919 - 1737 WP_038927200.1 type IV secretory system conjugative DNA transfer family protein -
DD1591_RS07395 1698683..1698985 - 303 WP_012769211.1 lipoprotein -
DD1591_RS07400 1699026..1700042 - 1017 WP_012769212.1 P-type DNA transfer ATPase VirB11 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - hcp / vgrG1 1679148..1732972 53824


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-103)

Antitoxin

Post-segregation antitoxin CcdA

(9-78)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11514.46 Da        Isoelectric Point: 7.9859

>T23954 WP_012769208.1 NC_012912:1695111-1695425 [Dickeya chrysanthemi Ech1591]
MQFTVYGNTGKSVVYPLLLDVTSDIIGQLNRRIVIPLLPVEKYPAGRRPERLVPVVRLTDGKEYAVMTHELASIPVQALG
AVFCDASQYRNQVKAAIDFLIDGI

Download         Length: 315 bp

>T23954 NC_012912:1695111-1695425 [Dickeya chrysanthemi Ech1591]
ATGCAATTCACCGTATACGGTAATACCGGGAAAAGCGTCGTTTACCCGCTATTGCTTGATGTCACGAGCGATATTATTGG
ACAGTTGAATCGTCGGATAGTGATCCCGTTGCTCCCTGTTGAAAAGTATCCGGCAGGCCGCCGACCGGAGCGCCTTGTCC
CCGTCGTCAGGCTGACGGACGGCAAAGAATACGCCGTAATGACCCACGAGCTGGCAAGTATCCCTGTCCAGGCTCTGGGT
GCGGTGTTTTGTGATGCGTCGCAGTACCGTAATCAGGTAAAGGCCGCCATCGATTTCCTTATTGATGGCATTTAG

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 9013.03 Da        Isoelectric Point: 6.4631

>AT23954 WP_012769207.1 NC_012912:1694872-1695108 [Dickeya chrysanthemi Ech1591]
MTAKQRNTQSVTMTVERALLVRAREAGINLSATLSTALDAELRRHEAKKWQEENREAIDALNRFHDENGCFSDEYRTF

Download         Length: 237 bp

>AT23954 NC_012912:1694872-1695108 [Dickeya chrysanthemi Ech1591]
ATGACAGCGAAACAACGCAACACGCAGAGCGTGACCATGACGGTGGAGCGTGCCTTACTGGTCCGGGCGCGTGAAGCGGG
GATTAACCTGAGTGCTACTCTGTCAACCGCCCTGGATGCGGAGCTTCGCCGTCATGAAGCTAAAAAATGGCAGGAAGAGA
ACAGGGAAGCCATCGACGCATTAAATCGCTTTCATGATGAAAACGGCTGTTTCAGTGATGAATACAGGACGTTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB C6CEY2

Antitoxin

Source ID Structure
AlphaFold DB A0A7W2E4H0

References