Detailed information of TA system TA239538

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 3589037..3589700
• Replicon: chromosome
• Accession: NZ_CP094308
• Organism: Edwardsiella anguillarum strain R18-14-1

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: MQ096_RS16805
• Protein ID: WP_034164690.1
• Coordinates: 3589037..3589453 (-)
• Length: 139 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: D0ZDY6
• Locus tag: MQ096_RS16810
• Protein ID: WP_012849755.1
• Coordinates: 3589434..3589700 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MQ096_RS16785 (MQ096_16770)	3584967..3586700	-	1734	WP_283318035.1	single-stranded-DNA-specific exonuclease RecJ	-
MQ096_RS16790 (MQ096_16775)	3586705..3587421	-	717	WP_034164686.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
MQ096_RS16795 (MQ096_16780)	3587449..3588348	-	900	WP_034164688.1	site-specific tyrosine recombinase XerD	-
MQ096_RS16800 (MQ096_16785)	3588500..3589012	+	513	WP_034164689.1	flavodoxin FldB	-
MQ096_RS16805 (MQ096_16790)	3589037..3589453	-	417	WP_034164690.1	protein YgfX	Toxin
MQ096_RS16810 (MQ096_16795)	3589434..3589700	-	267	WP_012849755.1	FAD assembly factor SdhE	Antitoxin
MQ096_RS16815 (MQ096_16800)	3590049..3591047	+	999	WP_034164692.1	tRNA-modifying protein YgfZ	-
MQ096_RS16820 (MQ096_16805)	3591089..3591913	-	825	WP_034164693.1	shikimate 5-dehydrogenase	-
MQ096_RS16825 (MQ096_16810)	3592070..3592942	-	873	WP_034164695.1	nucleoside-specific channel-forming protein Tsx	-
MQ096_RS16830 (MQ096_16815)	3593551..3594201	+	651	WP_034164746.1	hemolysin III family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-131)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 139 a.a.
• Molecular weight: 16229.03 Da
• Isoelectric Point: 11.6049

>T239538 WP_034164690.1 NZ_CP094308:c3589453-3589037 [Edwardsiella anguillarum]
VVLWRCNVHVSWRTQVMFLLGHGALVLAILLAPWPENYSAFWLVLLVAVIFECIRSQRRIARNRGELQLLTPQVWHWQLR
EWRLARRPWVSDLGALLILQSTHGVPCRRRLWLAADSMSREEWGQLRRALLDTGDDRA

Nucleotide

• Length: 417 bp

>T239538 NZ_LR898874:310130-310405 [Escherichia coli]
ATGAGAACCCTGGTACAGGCTTTACGGAAGAAACAAAAAAATACATTGGATCAAATATTTAAATCTCCTGTTCCTCAAGG
GATTAAGTGGTCTGATATAGAGTCACTGGTTAAAGCATTAGGCGGAGAAATTAAGGAAGGAAGAGGTTCGCGTTGTAAGT
TCATACTAAATATGAGCGTTGCGTGTTTCCATCGGCCTCATCCGTCGCCAGATACCGATAAAGGCGCTGTAGAAAGCGTG
CGTGACTGGTTACTAAGTATAGGGGTAAAACCATGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10318.90 Da
• Isoelectric Point: 5.6951

>AT239538 WP_012849755.1 NZ_CP094308:c3589700-3589434 [Edwardsiella anguillarum]
MDINNKARVHWACRRGMRELDIAIMPFFEHEYDALNDADKQTFVRLLACDDPELFKWLMNQGKPDDADLARMITLIQTRN
KERGPLAL

Nucleotide

• Length: 267 bp

>AT239538 NZ_LR898874:310402-310761 [Escherichia coli]
ATGATCAAACTGAAGACGCCAAACTCTATGGAGATTGCCGGGCAACCTGCTGTTATCACTTACGTGCCAGAACTGAATGC
ATTTCGTGGCAAATTCCTGGGCTTGTCAGGTTATTGTGATTTTGTCTCTGACAGCATTCAGGGGCTGCAAAAAGAAGGGG
AGCTTTCCCTGCGAGAGTATCTTGAGGATTGTAAAGCTGCGGGTATTGAGCCGTATGCGCGTACAGAAAAGATTAAGACC
TTTACATTACGCTATCCAGAATCGCTGAGTGAACGCCTTAATAATGCGGCTGCGCAGCAACAAGTCTCTGTAAATACTTA
TATTATTGAAACGCTAAATGAGCGTTTGAATCATTTATAA

Structures

Antitoxin

• AlphaFold DB: A0A034T2Q8