Detailed information of TA system TA239503

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-DnaT
• Location: 1901490..1902012
• Replicon: chromosome
• Accession: NZ_CP094304
• Organism: Edwardsiella anguillarum strain R18-08

Toxin (Protein)

• Gene name: relE
• Uniprot ID: C5BBL4
• Locus tag: MQ088_RS09035
• Protein ID: WP_015871319.1
• Coordinates: 1901490..1901771 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: C5BBL3
• Locus tag: MQ088_RS09040
• Protein ID: WP_015871318.1
• Coordinates: 1901761..1902012 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MQ088_RS09015 (MQ088_09005)	1896891..1897109	+	219	WP_225865175.1	hypothetical protein	-
MQ088_RS09020 (MQ088_09010)	1897271..1897666	+	396	WP_225865176.1	hypothetical protein	-
MQ088_RS09025 (MQ088_09015)	1897659..1899320	+	1662	WP_049703944.1	terminase	-
MQ088_RS09030 (MQ088_09025)	1899317..1901418	+	2102	Protein_1733	portal protein	-
MQ088_RS09035 (MQ088_09030)	1901490..1901771	-	282	WP_015871319.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
MQ088_RS09040 (MQ088_09035)	1901761..1902012	-	252	WP_015871318.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
MQ088_RS09045 (MQ088_09040)	1902300..1902791	+	492	WP_225865179.1	hypothetical protein	-
MQ088_RS09050 (MQ088_09045)	1902778..1903125	+	348	WP_144242832.1	hypothetical protein	-
MQ088_RS09055 (MQ088_09050)	1903497..1905371	+	1875	WP_034165826.1	PhoX family phosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1868796..1920357	51561

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-84)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10783.62 Da
• Isoelectric Point: 10.6993

>T239503 WP_015871319.1 NZ_CP094304:c1901771-1901490 [Edwardsiella anguillarum]
MTYKLSFEKRALKEWKKLAPPIQSQLKKKLIERLENPHVPAARLSGRANRYKIKLRSSGYRLVYEVNDSEIILLVIAIGK
RADNEVYQAADSR

Nucleotide

• Length: 282 bp

>T239503 NZ_LR890751:c5216335-5215952 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9155.24 Da
• Isoelectric Point: 3.7550

>AT239503 WP_015871318.1 NZ_CP094304:c1902012-1901761 [Edwardsiella anguillarum]
MAYQILTTTAASITDLKRNPMGTIAEGDGNAVAILNRNEPAFYCVPPELYAYYLELAEDAALNRIADERLEDAEFVSVNI
DDL

Nucleotide

• Length: 252 bp

>AT239503 NZ_LR890751:c5216577-5216335 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Structures

Toxin

• AlphaFold DB: C5BBL4

Antitoxin

• AlphaFold DB: C5BBL3