Detailed information of TA system TA239500

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vagCD/VapC-VagC
• Location: 30813..31456
• Replicon: plasmid unnamed7
• Accession: NZ_CP094303
• Organism: Edwardsiella anguillarum strain R18-35-2

Toxin (Protein)

• Gene name: vagD
• Uniprot ID: -
• Locus tag: MQ095_RS19990
• Protein ID: WP_283292435.1
• Coordinates: 31040..31456 (+)
• Length: 139 a.a.

Antitoxin (Protein)

• Gene name: vagC
• Uniprot ID: A0A6C0NE67
• Locus tag: MQ095_RS19985
• Protein ID: WP_008322219.1
• Coordinates: 30813..31043 (+)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MQ095_RS19970 (MQ095_19945)	26918..28006	+	1089	WP_283292455.1	transcriptional repressor PifC	-
MQ095_RS19975 (MQ095_19950)	28008..28877	+	870	WP_068872224.1	hypothetical protein	-
MQ095_RS19980 (MQ095_19955)	28926..30497	-	1572	WP_283292432.1	AAA family ATPase	-
MQ095_RS19985 (MQ095_19960)	30813..31043	+	231	WP_008322219.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
MQ095_RS19990 (MQ095_19965)	31040..31456	+	417	WP_283292435.1	type II toxin-antitoxin system VapC family toxin	Toxin
MQ095_RS19995 (MQ095_19970)	31530..33092	+	1563	WP_283292438.1	AAA family ATPase	-
MQ095_RS20000 (MQ095_19975)	33077..34099	+	1023	WP_283292440.1	DNA helicase UvrD	-
MQ095_RS20005 (MQ095_19980)	34260..34979	-	720	Protein_38	IS3 family transposase	-
MQ095_RS20010 (MQ095_19985)	35036..35836	-	801	WP_283292457.1	IS21-like element helper ATPase IstB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	papD / papC	1..91492	91492

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-129)

Antitoxin

• SpoVT-AbrB domain (7-50)

Sequences

Toxin

Protein

• Length: 139 a.a.
• Molecular weight: 15132.48 Da
• Isoelectric Point: 7.3236

>T239500 WP_283292435.1 NZ_CP094303:31040-31456 [Edwardsiella anguillarum]
VNKTYMLDTNICSFIMREQPDVVLKHLEQAVLRGHRIVVSAITYSEMRFGATGPKASPRHVQLVDAFCARLDAILPWDRA
AVDATTEIKLSLRLAGTPIGPNDTAIAGHAIAAGAVLVTNNTREFERVPGLVLEDWVR

Nucleotide

• Length: 417 bp

>T239500 NZ_LR890751:c4637121-4636588 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGCGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAGGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 8736.84 Da
• Isoelectric Point: 4.4692

>AT239500 WP_008322219.1 NZ_CP094303:30813-31043 [Edwardsiella anguillarum]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFAQLEKADPDFMAEREDVVTDEGRFNL

Nucleotide

• Length: 231 bp

>AT239500 NZ_LR890751:c4637398-4637132 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA

Structures

Antitoxin

• AlphaFold DB: A0A6C0NE67