Detailed information of TA system TA239499

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 3588591..3589254
• Replicon: chromosome
• Accession: NZ_CP094302
• Organism: Edwardsiella anguillarum strain R18-35-2

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: MQ095_RS16820
• Protein ID: WP_034164690.1
• Coordinates: 3588591..3589007 (-)
• Length: 139 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: D0ZDY6
• Locus tag: MQ095_RS16825
• Protein ID: WP_012849755.1
• Coordinates: 3588988..3589254 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MQ095_RS16800 (MQ095_16775)	3584521..3586254	-	1734	WP_034164685.1	single-stranded-DNA-specific exonuclease RecJ	-
MQ095_RS16805 (MQ095_16780)	3586259..3586975	-	717	WP_034164686.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
MQ095_RS16810 (MQ095_16785)	3587003..3587902	-	900	WP_034164688.1	site-specific tyrosine recombinase XerD	-
MQ095_RS16815 (MQ095_16790)	3588054..3588566	+	513	WP_034164689.1	flavodoxin FldB	-
MQ095_RS16820 (MQ095_16795)	3588591..3589007	-	417	WP_034164690.1	protein YgfX	Toxin
MQ095_RS16825 (MQ095_16800)	3588988..3589254	-	267	WP_012849755.1	FAD assembly factor SdhE	Antitoxin
MQ095_RS16830 (MQ095_16805)	3589603..3590601	+	999	WP_034164692.1	tRNA-modifying protein YgfZ	-
MQ095_RS16835 (MQ095_16810)	3590643..3591467	-	825	WP_034164693.1	shikimate 5-dehydrogenase	-
MQ095_RS16840 (MQ095_16815)	3591624..3592496	-	873	WP_034164695.1	nucleoside-specific channel-forming protein Tsx	-
MQ095_RS16845 (MQ095_16820)	3593105..3593755	+	651	WP_034164746.1	hemolysin III family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-131)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 139 a.a.
• Molecular weight: 16229.03 Da
• Isoelectric Point: 11.6049

>T239499 WP_034164690.1 NZ_CP094302:c3589007-3588591 [Edwardsiella anguillarum]
VVLWRCNVHVSWRTQVMFLLGHGALVLAILLAPWPENYSAFWLVLLVAVIFECIRSQRRIARNRGELQLLTPQVWHWQLR
EWRLARRPWVSDLGALLILQSTHGVPCRRRLWLAADSMSREEWGQLRRALLDTGDDRA

Nucleotide

• Length: 417 bp

>T239499 NZ_LR890751:4030298-4030516 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACCTCTGTCTGGAAATTTATCCGCTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10318.90 Da
• Isoelectric Point: 5.6951

>AT239499 WP_012849755.1 NZ_CP094302:c3589254-3588988 [Edwardsiella anguillarum]
MDINNKARVHWACRRGMRELDIAIMPFFEHEYDALNDADKQTFVRLLACDDPELFKWLMNQGKPDDADLARMITLIQTRN
KERGPLAL

Nucleotide

• Length: 267 bp

>AT239499 NZ_LR890751:4029897-4030271 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Structures

Antitoxin

• AlphaFold DB: A0A034T2Q8