Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1168741..1169333 Replicon chromosome
Accession NZ_CP094302
Organism Edwardsiella anguillarum strain R18-35-2

Toxin (Protein)


Gene name Hha Uniprot ID D0ZEC2
Locus tag MQ095_RS05425 Protein ID WP_012847872.1
Coordinates 1168741..1168944 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A034T4H2
Locus tag MQ095_RS05430 Protein ID WP_034163649.1
Coordinates 1168965..1169333 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MQ095_RS05395 (MQ095_05395) 1164537..1164998 + 462 WP_034163655.1 Lrp/AsnC family transcriptional regulator -
MQ095_RS05400 (MQ095_05400) 1165276..1165614 + 339 WP_034163654.1 P-II family nitrogen regulator -
MQ095_RS05405 (MQ095_05405) 1165635..1166915 + 1281 WP_034163814.1 ammonium transporter AmtB -
MQ095_RS05410 (MQ095_05410) 1166950..1167816 - 867 WP_034163652.1 acyl-CoA thioesterase II -
MQ095_RS05415 (MQ095_05415) 1167925..1168254 - 330 WP_034163651.1 MGMT family protein -
MQ095_RS05425 (MQ095_05425) 1168741..1168944 - 204 WP_012847872.1 HHA domain-containing protein Toxin
MQ095_RS05430 (MQ095_05430) 1168965..1169333 - 369 WP_034163649.1 Hha toxicity modulator TomB Antitoxin
MQ095_RS05435 (MQ095_05435) 1169700..1172852 - 3153 WP_034163648.1 efflux RND transporter permease subunit -
MQ095_RS05440 (MQ095_05440) 1172896..1174080 - 1185 WP_034163646.1 efflux RND transporter periplasmic adaptor subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-115)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8103.37 Da        Isoelectric Point: 5.0914

>T239489 WP_012847872.1 NZ_CP094302:c1168944-1168741 [Edwardsiella anguillarum]
MTKIDYLMKLRKCTTLDTLERVIEKNKYELSDDELEIFYSAADHRLAELTMNKLYDKIPAEVWQYVR

Download         Length: 204 bp

>T239489 NZ_LR890735:c5142741-5142358 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14118.85 Da        Isoelectric Point: 6.2108

>AT239489 WP_034163649.1 NZ_CP094302:c1169333-1168965 [Edwardsiella anguillarum]
MDEYTSYQHDIAELKYLCDSLYHQGIDVLGESHHGWVSDPTAKVNLQLNELIEHIASVAQSFKIKYPRHSDLAEILDDYL
DETYALFGAYSVSETALRHWLRTKRRVAYCLAHEKRNAALHV

Download         Length: 369 bp

>AT239489 NZ_LR890735:c5142983-5142741 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A034SMG4

Antitoxin

Source ID Structure
AlphaFold DB A0A034T4H2

References