Detailed information of TA system TA239488

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 3326555..3327218
• Replicon: chromosome
• Accession: NZ_CP094301
• Organism: Edwardsiella anguillarum strain A20-09557

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: MQ090_RS15125
• Protein ID: WP_283293889.1
• Coordinates: 3326555..3326971 (-)
• Length: 139 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: D0ZDY6
• Locus tag: MQ090_RS15130
• Protein ID: WP_012849755.1
• Coordinates: 3326952..3327218 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MQ090_RS15105 (MQ090_15080)	3322485..3324218	-	1734	WP_283293888.1	single-stranded-DNA-specific exonuclease RecJ	-
MQ090_RS15110 (MQ090_15085)	3324223..3324939	-	717	WP_045426732.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
MQ090_RS15115 (MQ090_15090)	3324967..3325866	-	900	WP_034164688.1	site-specific tyrosine recombinase XerD	-
MQ090_RS15120 (MQ090_15095)	3326018..3326530	+	513	WP_034164689.1	flavodoxin FldB	-
MQ090_RS15125 (MQ090_15100)	3326555..3326971	-	417	WP_283293889.1	protein YgfX	Toxin
MQ090_RS15130 (MQ090_15105)	3326952..3327218	-	267	WP_012849755.1	FAD assembly factor SdhE	Antitoxin
MQ090_RS15135 (MQ090_15110)	3327567..3328565	+	999	WP_283293890.1	tRNA-modifying protein YgfZ	-
MQ090_RS15140 (MQ090_15115)	3328607..3329431	-	825	WP_034164693.1	shikimate 5-dehydrogenase	-
MQ090_RS15145 (MQ090_15120)	3329588..3330460	-	873	WP_034164695.1	nucleoside-specific channel-forming protein Tsx	-
MQ090_RS15150 (MQ090_15125)	3331069..3331719	+	651	WP_034164746.1	hemolysin III family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-131)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 139 a.a.
• Molecular weight: 16229.03 Da
• Isoelectric Point: 11.6049

>T239488 WP_283293889.1 NZ_CP094301:c3326971-3326555 [Edwardsiella anguillarum]
VVLWRCNVHVSWRTQVMFLLGHGALVLAILLAPWPENYSAFWLVLLVAVIFECIRSQRRIARNRGELQLLAPQVWHWQLR
EWRLARRPWVSDLGALLILQSTHGVPCRRRLWLAADSMSREEWGQLRRTLLDTGDDRA

Nucleotide

• Length: 417 bp

>T239488 NZ_LR890735:c4669042-4668758 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCTCGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGCCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTTCGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCAGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10318.90 Da
• Isoelectric Point: 5.6951

>AT239488 WP_012849755.1 NZ_CP094301:c3327218-3326952 [Edwardsiella anguillarum]
MDINNKARVHWACRRGMRELDIAIMPFFEHEYDALNDADKQTFVRLLACDDPELFKWLMNQGKPDDADLARMITLIQTRN
KERGPLAL

Nucleotide

• Length: 267 bp

>AT239488 NZ_LR890735:c4669274-4669032 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGTGTCTGGATGACCTA
TGA

Structures

Antitoxin

• AlphaFold DB: A0A034T2Q8