Detailed information of TA system TA239479

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-DnaT
• Location: 1815913..1816435
• Replicon: chromosome
• Accession: NZ_CP094301
• Organism: Edwardsiella anguillarum strain A20-09557

Toxin (Protein)

• Gene name: relE
• Uniprot ID: C5BBL4
• Locus tag: MQ090_RS08430
• Protein ID: WP_015871319.1
• Coordinates: 1815913..1816194 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: C5BBL3
• Locus tag: MQ090_RS08435
• Protein ID: WP_015871318.1
• Coordinates: 1816184..1816435 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MQ090_RS08415 (MQ090_08405)	1811300..1812076	+	777	WP_283294719.1	hypothetical protein	-
MQ090_RS08420 (MQ090_08410)	1812069..1813730	+	1662	WP_283294840.1	terminase	-
MQ090_RS08425 (MQ090_08415)	1813727..1815841	+	2115	WP_283294720.1	portal protein	-
MQ090_RS08430 (MQ090_08420)	1815913..1816194	-	282	WP_015871319.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
MQ090_RS08435 (MQ090_08425)	1816184..1816435	-	252	WP_015871318.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
MQ090_RS08440 (MQ090_08430)	1816723..1817214	+	492	WP_283294721.1	hypothetical protein	-
MQ090_RS08445 (MQ090_08435)	1817201..1817515	+	315	WP_283294722.1	hypothetical protein	-
MQ090_RS08450 (MQ090_08440)	1817920..1819794	+	1875	WP_045427621.1	PhoX family phosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1780989..1826402	45413

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-84)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10783.62 Da
• Isoelectric Point: 10.6993

>T239479 WP_015871319.1 NZ_CP094301:c1816194-1815913 [Edwardsiella anguillarum]
MTYKLSFEKRALKEWKKLAPPIQSQLKKKLIERLENPHVPAARLSGRANRYKIKLRSSGYRLVYEVNDSEIILLVIAIGK
RADNEVYQAADSR

Nucleotide

• Length: 282 bp

>T239479 NZ_LR890730:c1957-1622 [Klebsiella pneumoniae]
ATGGAATACTACGAGTTTGTAGAAACCTCTGTATTCACGCGAGAGATGAAAACTCTACTCAGTGATGATGAATACAAAGA
GTTTCAAACGTTCCTCATCGAGAACCCGGAAGCGGGTGATCTGATAGTAGGAACTGGCGGTTGTCGTAAGGTTAGATGGT
CAAGACAGGGAACTGGTAAAAGTTCAGGTGTCCGGGCTATTTACTACTTCTACAATCCGGCAGGCCGCTTATACATGCTT
ATCATCTATCCGAAGAGTGAGAAGGATAGTTTGACGGCAGCAGAGAAAAACCAGCTCAAAGCGGTTGTAGCGGGTTTTAA
AGGTGAAGAGGGCTAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9155.24 Da
• Isoelectric Point: 3.7550

>AT239479 WP_015871318.1 NZ_CP094301:c1816435-1816184 [Edwardsiella anguillarum]
MAYQILTTTAASITDLKRNPMGTIAEGDGNAVAILNRNEPAFYCVPPELYAYYLELAEDAALNRIADERLEDAEFVSVNI
DDL

Nucleotide

• Length: 252 bp

>AT239479 NZ_LR890730:c1617-1327 [Klebsiella pneumoniae]
ATGCGTAAAGAGCTTTTTGATGATCTGATTGCTTCTGCTAAGGAAGCTGTAGAAATCCATCAGGGTTTACGTGAGCCAGC
TCGCGTGACCCGTTTTGAACGTCCAGATGTTAAGGCTATCCGGGCTAAGGTTCATATGAAACAAGATGATTTTGCCAGCC
TGATCGGGGTTAGCTCTTCTCTTGTTCAGTCATGGGAACAGGGGTTAAGAACTCCAGCAGGTGCAGCGTTAAAGCTGTTG
CGTGTCATCGAGCGTAAACCTGAGTTTGTTCAGGAACTACGTGAAGCATAA

Structures

Toxin

• AlphaFold DB: C5BBL4

Antitoxin

• AlphaFold DB: C5BBL3