Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DhiAT/dnstrm_HI1420(antitoxin)
Location 1803781..1804560 Replicon chromosome
Accession NZ_CP094301
Organism Edwardsiella anguillarum strain A20-09557

Toxin (Protein)


Gene name dhiT Uniprot ID -
Locus tag MQ090_RS08360 Protein ID WP_198077053.1
Coordinates 1804303..1804560 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name dhiA Uniprot ID -
Locus tag MQ090_RS08355 Protein ID WP_283294710.1
Coordinates 1803781..1804293 (-) Length 171 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MQ090_RS08325 (MQ090_08315) 1798906..1800288 + 1383 WP_283294703.1 replicative DNA helicase -
MQ090_RS08330 (MQ090_08320) 1800316..1800663 + 348 WP_283294704.1 hypothetical protein -
MQ090_RS08335 (MQ090_08325) 1800773..1801417 + 645 WP_034165085.1 DUF1367 family protein -
MQ090_RS08340 (MQ090_08330) 1801420..1801719 + 300 WP_283294705.1 DUF1364 family protein -
MQ090_RS08345 (MQ090_08335) 1801864..1802904 + 1041 WP_283294706.1 hypothetical protein -
MQ090_RS08350 (MQ090_08340) 1802905..1803414 + 510 WP_071525693.1 hypothetical protein -
MQ090_RS08355 (MQ090_08345) 1803781..1804293 - 513 WP_283294710.1 DUF2442 domain-containing protein Antitoxin
MQ090_RS08360 (MQ090_08350) 1804303..1804560 - 258 WP_198077053.1 DUF4160 domain-containing protein Toxin
MQ090_RS08365 (MQ090_08355) 1804930..1805700 + 771 WP_283294713.1 Rha family transcriptional regulator -
MQ090_RS08370 (MQ090_08360) 1805822..1806337 + 516 WP_034165088.1 hypothetical protein -
MQ090_RS08375 (MQ090_08365) 1806426..1807244 + 819 WP_283294714.1 hypothetical protein -
MQ090_RS08380 (MQ090_08370) 1807478..1807876 + 399 WP_144242831.1 hypothetical protein -
MQ090_RS08385 (MQ090_08375) 1807993..1808223 + 231 WP_034165090.1 ParD-like family protein -
MQ090_RS08390 (MQ090_08380) 1808198..1808527 + 330 WP_283294715.1 type II toxin-antitoxin system RelE/ParE family toxin -
MQ090_RS08395 (MQ090_08385) 1808613..1808960 + 348 WP_283294716.1 phage holin, lambda family -
MQ090_RS08400 (MQ090_08390) 1808963..1809514 + 552 WP_283294717.1 glycosyl hydrolase 108 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1780989..1826402 45413


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF4160

(9-74)

Antitoxin

Uncharacterized protein HI1420

(82-161)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9625.29 Da        Isoelectric Point: 7.4665

>T239478 WP_198077053.1 NZ_CP094301:c1804560-1804303 [Edwardsiella anguillarum]
MPEIDALMGLSFVMYFFDNQTHSLPHVHVKYGEFELVIGIDSGEALEGYLPPKKRKLAESHIKANKTRLLAMWQMAVNGM
HPGKL

Download         Length: 258 bp

>T239478 NZ_LR890729:c69779-69456 [Klebsiella pneumoniae]
ATGAGCGACAATTTTACAACAAAGCTGACGTTCAAAAGGCTTGCTCTGGCCGAGTGGGAGTCGCTATCCACACCCATAAG
GGATAAGTTCAAGAAGGTTTTGGCTAAGCGTCTGGAGTCACTGGATTCGCTGACGATGCCGAAAAATAGGCTCTCACTTC
AGCATAATTGCTACAAGATTAAGCTGAAGAACGACGGCTATCGTTTGGCTTATACGGTAAAAAATGACGAGTCCGGCACC
GTCACCGTCGTAGTAACTGTCGTTGCAGTTGACCGCCGTGATGAAATTTACAATGAGTTGAAAAAGAGACTCAATGACGA
ATAG

Antitoxin


Download         Length: 171 a.a.        Molecular weight: 18249.67 Da        Isoelectric Point: 7.3201

>AT239478 WP_283294710.1 NZ_CP094301:c1804293-1803781 [Edwardsiella anguillarum]
MLKIIDVDVVGDHVIEVEFSDGFRGRADLTALFSKPPFSAIADFNRFSLTASGVLNWGDAELSADTVRRMSKGAVVSASS
RSLMPENVEAILRQATWESMSEGRPDILQAALRGYAEQLGHADVIKRAGIASRSSAYKTLSPSTNPSFKSLAKISGAILA
IVRENNAQHG

Download         Length: 513 bp

>AT239478 NZ_LR890729:c70030-69779 [Klebsiella pneumoniae]
ATGTTCACTGAAACGGTACTGGCCAAACGCACATCGTCTATTAGCGAGTTCAAGAAGAACCCGTCCGCCGCAATGAGTGA
GTCGCATGGCGAGCCTGTCGCTGTCCTGAGCCACAACAAGCCGGCCTTTTACTGCGTCCCACCCGCTCTGTTTGCCCTCA
TGATGGACCAGATTGGCGACCAGCTCCTTCTGGATAAGGCTATGTCTCGACTGGATGATGATGAGGTGGAAGTCACCCTG
GATCAGCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References