Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1111305..1111897 Replicon chromosome
Accession NZ_CP094301
Organism Edwardsiella anguillarum strain A20-09557

Toxin (Protein)


Gene name Hha Uniprot ID D0ZEC2
Locus tag MQ090_RS05060 Protein ID WP_012847872.1
Coordinates 1111305..1111508 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A034T4H2
Locus tag MQ090_RS05065 Protein ID WP_034163649.1
Coordinates 1111529..1111897 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MQ090_RS05040 (MQ090_05045) 1106605..1108305 - 1701 WP_175565808.1 hypothetical protein -
MQ090_RS05045 (MQ090_05050) 1108302..1109354 - 1053 WP_032082908.1 nucleoid-associated protein -
MQ090_RS05050 (MQ090_05055) 1109740..1110360 + 621 WP_001267012.1 recombinase family protein -
MQ090_RS05055 (MQ090_05060) 1110578..1110805 + 228 WP_024183738.1 DUF2188 domain-containing protein -
MQ090_RS05060 (MQ090_05065) 1111305..1111508 - 204 WP_012847872.1 HHA domain-containing protein Toxin
MQ090_RS05065 (MQ090_05070) 1111529..1111897 - 369 WP_034163649.1 Hha toxicity modulator TomB Antitoxin
MQ090_RS05070 (MQ090_05075) 1112264..1115416 - 3153 WP_034163648.1 efflux RND transporter permease subunit -
MQ090_RS05075 (MQ090_05080) 1115460..1116644 - 1185 WP_034163646.1 efflux RND transporter periplasmic adaptor subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-115)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8103.37 Da        Isoelectric Point: 5.0914

>T239477 WP_012847872.1 NZ_CP094301:c1111508-1111305 [Edwardsiella anguillarum]
MTKIDYLMKLRKCTTLDTLERVIEKNKYELSDDELEIFYSAADHRLAELTMNKLYDKIPAEVWQYVR

Download         Length: 204 bp

>T239477 NZ_LR890726:c5155254-5154871 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGTACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14118.85 Da        Isoelectric Point: 6.2108

>AT239477 WP_034163649.1 NZ_CP094301:c1111897-1111529 [Edwardsiella anguillarum]
MDEYTSYQHDIAELKYLCDSLYHQGIDVLGESHHGWVSDPTAKVNLQLNELIEHIASVAQSFKIKYPRHSDLAEILDDYL
DETYALFGAYSVSETALRHWLRTKRRVAYCLAHEKRNAALHV

Download         Length: 369 bp

>AT239477 NZ_LR890726:c5155496-5155254 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A034SMG4

Antitoxin

Source ID Structure
AlphaFold DB A0A034T4H2

References