Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 6192773..6193343 Replicon chromosome
Accession NZ_CP094298
Organism Streptomyces rimosus subsp. rimosus strain R7

Toxin (Protein)


Gene name mazF Uniprot ID L8ERH5
Locus tag SRIMR7_RS26825 Protein ID WP_003982453.1
Coordinates 6192996..6193343 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID L8ERT3
Locus tag SRIMR7_RS26820 Protein ID WP_003982452.1
Coordinates 6192773..6193009 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SRIMR7_RS26805 (SRIMR7_26890) 6188195..6189352 + 1158 WP_003982449.1 allantoicase -
SRIMR7_RS26810 (SRIMR7_26895) 6189424..6192000 - 2577 WP_003982450.1 aminopeptidase N -
SRIMR7_RS26815 (SRIMR7_26900) 6192134..6192733 + 600 WP_003982451.1 Uma2 family endonuclease -
SRIMR7_RS26820 (SRIMR7_26905) 6192773..6193009 + 237 WP_003982452.1 ribbon-helix-helix domain-containing protein Antitoxin
SRIMR7_RS26825 (SRIMR7_26910) 6192996..6193343 + 348 WP_003982453.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
SRIMR7_RS26830 (SRIMR7_26915) 6193424..6193945 + 522 WP_003982454.1 DUF1203 domain-containing protein -
SRIMR7_RS26835 (SRIMR7_26920) 6194016..6195047 - 1032 WP_003982455.1 aspartate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 12493.43 Da        Isoelectric Point: 10.8691

>T239476 WP_003982453.1 NZ_CP094298:6192996-6193343 [Streptomyces rimosus subsp. rimosus]
MRRGDLYLVDLEPVRGSEANKYRPAVVVSNDAANRSVQRAGRGVVTVVPVTANVARVYPFQVLLTADDCGLPRDSKAQCE
QVRAVSVERLGRRVGSVPARVMVGLDAALRRHLAL

Download         Length: 348 bp

>T239476 NZ_LR890726:c4808123-4807206 [Klebsiella pneumoniae]
ATGGATATACAGGCGCCTTATTATCGGCAGGTTGCTCTGCTAATGCAGGTTTTACCCTATGTTGCTGTCGAACGGGAATT
TGCGCTGAAAGGTGGCACTGCCATCAATCTCTTTATCCGCGATTTCCCTCGATTATCGGTGGATATCGACCTCGCCTGGG
TGCCCCTGGAAAGCAGAGCCATCGCTTTACCTCATATACGGGATGCGCTTGCACGTATTGCCGCCAATCTGCAACAACAG
GCAGGTATGAGCGCTGTATTACAAGCTAATCGTTCAGATGAGATGCGTGTCATTGTTACTACCGATAGCGCGCAAATAAA
GATAGAGGTTTCACCGGTCGCCCGGGGAACATTATATCCACCACAGGAGCGAGAAGTGGTGGGGGCGGTAGAGGACGTTT
TTGGCTATGCCAGCCTTCCAGTGGTTTCGTTGCCTGACCTCTACGGTGGAAAATTATGCGCGGCGCTGGATCGCCAGCAT
CCCAGAGATTTTTATGACGTGAAATTACTTCTTGATGCGCAGGAGCTTGACCGTCCCATTTTCAATGGGTTTATCGCGTA
TTTACTGAGCCATAATCGGCCTCTGGCTGAAGTGCTGAATCCTCGCTGGAAAGATATTGCTGAACCTTTTTACCGTGAAT
TCAGCGGGATGACATTTGAGACGATAGCCCTGGAGGAACTGACAGCAGTCCCCAACAGGATGATTGCTGCGTTAAAATCC
TGTTTCACACAACAGGATGTCGATTTTTTACTGTCATTTAAACGAGGCGAACCAGACTGGCGTTTAGCGCCGGAAATGCG
TATTCAGGATTTGCCTGCCGTGCAGTGGAAATTGCGCAATATTCATCAGATGCCAGCGATAAAACGCGCTGAGTCATTAG
ATAAACTGGAAAAGGTGCTGGCCGAGTGGCGCAGTTAG

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8374.07 Da        Isoelectric Point: 3.7856

>AT239476 WP_003982452.1 NZ_CP094298:6192773-6193009 [Streptomyces rimosus subsp. rimosus]
MKISVSLPEEDIAFLDAYGKKTDADSRSAVIHAAVELLRASELEADYASAWEEWDESDDALLWDGVSGDGIGSADAAR

Download         Length: 237 bp

>AT239476 NZ_LR890726:c4808887-4808129 [Klebsiella pneumoniae]
ATGGCAACAAAATTAAACTGGCTGCTGCAAAACAGCGCTCCCGGAGATGTGATCCTTCAGTCCTGGTTAAGCCAGCATGC
CATCTCTCCCTCTCTGGCCTTTAAATACGCGCAAAGTGGCTGGTTAAAAAAAAGAGGCAACGGCGTATATGCGCGTGCGG
GACGTGAGCCGGAGTGGAACGATGCATTAGCATGTTTGCAAAATCAGCTTGCCGCTCCGGTGTATGTTGCGGGGCTCAGT
AGCTTAGTCTGGCAGGGCCGTTCACACTATCTACAGCTAAAACAAAACCAGTGCTGGCTTAGTGTGGAAAATAAAGCGCT
GCTGCCGAAATGGTTCAGGGAATTCCCGGGTGTGGAGTGGATAGTCATATCGGGGAAAAAACTGCCGGTGCTGGATGATA
GATACCGTGTAACGCTTGATATAAAAGGGAAAAAACTCATCGGCAGTGCGCCAGAACTGGCTGCTTACGAGTTGCTGAGC
GCGGTGCCGGGGACCCTCTCATTTAACCACGCTGCAGAGCTTTTCCAGGGGCTGGTTAATCTTAATCCTCGTAAAGTAGA
GTATCTTCTTTCCGTCAGCCAGTCCGTGCAGGCCAAGCGTTTGTATCTCTTCTTCGCCAGTTTTTACGAGCATGGCTGGC
TCAAACGAATCGATAGCCAAAAAATCGATCTGGGAGCGGGCAAGCGGCAAATCGTGGAAAATGGAAAGTTCAATGCTCAA
TACCAAATCACAGTGCCTGAACGCTTTCAAAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB L8ERH5

Antitoxin

Source ID Structure
AlphaFold DB L8ERT3

References