Detailed information of TA system TA239475

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-Phd
• Location: 3425727..3426252
• Replicon: chromosome
• Accession: NZ_CP094298
• Organism: Streptomyces rimosus subsp. rimosus strain R7

Toxin (Protein)

• Gene name: relE
• Uniprot ID: L8EGB8
• Locus tag: SRIMR7_RS14045
• Protein ID: WP_003987428.1
• Coordinates: 3425989..3426252 (+)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: L8ED57
• Locus tag: SRIMR7_RS14040
• Protein ID: WP_003987429.1
• Coordinates: 3425727..3425996 (+)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SRIMR7_RS14015 (SRIMR7_14090)	3420760..3421482	+	723	WP_030181983.1	PIG-L deacetylase family protein	-
SRIMR7_RS14020 (SRIMR7_14095)	3421470..3422438	-	969	WP_003982326.1	alpha/beta hydrolase	-
SRIMR7_RS14025 (SRIMR7_14100)	3422568..3423077	+	510	WP_003982327.1	hypothetical protein	-
SRIMR7_RS14030 (SRIMR7_14105)	3423118..3423702	+	585	WP_003982328.1	Uma2 family endonuclease	-
SRIMR7_RS14035 (SRIMR7_14110)	3423744..3425423	-	1680	WP_076611972.1	IS1182-like element ISSdi1 family transposase	-
SRIMR7_RS14040 (SRIMR7_14115)	3425727..3425996	+	270	WP_003987429.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
SRIMR7_RS14045 (SRIMR7_14120)	3425989..3426252	+	264	WP_003987428.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
SRIMR7_RS14050 (SRIMR7_14125)	3426387..3427475	-	1089	WP_003987427.1	redox-regulated ATPase YchF	-
SRIMR7_RS14055 (SRIMR7_14130)	3428018..3428725	+	708	WP_063604328.1	hypothetical protein	-
SRIMR7_RS14060 (SRIMR7_14135)	3428691..3429563	-	873	WP_078586864.1	ROK family protein	-
SRIMR7_RS14065 (SRIMR7_14140)	3429649..3430692	-	1044	WP_078586862.1	4-hydroxy-3-methylbut-2-enyl diphosphate reductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	3423744..3425423	1679

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-85)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (9-56)

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 10084.54 Da
• Isoelectric Point: 8.5041

>T239475 WP_003987428.1 NZ_CP094298:3425989-3426252 [Streptomyces rimosus subsp. rimosus]
VSEYRTVFRPEAQTELRKVPRDMALRILAKLTELETDPLGFNTTALVSQPDRRRLRVGDYRLIYTIDNGELVVWVVHVGH
RSTVYDA

Nucleotide

• Length: 264 bp

>T239475 NZ_LR890726:c4568298-4567765 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGCGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAGGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 10290.73 Da
• Isoelectric Point: 4.7473

>AT239475 WP_003987429.1 NZ_CP094298:3425727-3425996 [Streptomyces rimosus subsp. rimosus]
MTQPLPIESIRDVRAHLAEVVERADRDDVPTVITRRGKQVAAVVSIETLRKYQEWEEREINRIIDERMANPAPGIPLEDI
MRETLARSE

Nucleotide

• Length: 270 bp

>AT239475 NZ_LR890726:c4568575-4568309 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAGTGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA

Structures

Toxin

• AlphaFold DB: L8EGB8

Antitoxin

• AlphaFold DB: L8ED57