Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 3334594..3335216 Replicon chromosome
Accession NZ_CP094289
Organism Georgenia sp. TF02-10

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag MF406_RS15150 Protein ID WP_242895382.1
Coordinates 3334594..3335007 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag MF406_RS15155 Protein ID WP_242895384.1
Coordinates 3335004..3335216 (-) Length 71 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MF406_RS15130 (MF406_15130) 3329860..3331455 + 1596 WP_242895367.1 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase -
MF406_RS15135 (MF406_15135) 3331529..3332695 + 1167 WP_242895369.1 3,4-dihydroxyphenylacetate 2,3-dioxygenase -
MF406_RS15140 (MF406_15140) 3332813..3333598 + 786 WP_242895378.1 fumarylacetoacetate hydrolase family protein -
MF406_RS15145 (MF406_15145) 3333583..3334401 + 819 WP_242895380.1 aldolase/citrate lyase family protein -
MF406_RS15150 (MF406_15150) 3334594..3335007 - 414 WP_242895382.1 PIN domain nuclease Toxin
MF406_RS15155 (MF406_15155) 3335004..3335216 - 213 WP_242895384.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
MF406_RS15160 (MF406_15160) 3335334..3335861 - 528 WP_242895386.1 GNAT family N-acetyltransferase -
MF406_RS15165 (MF406_15165) 3336068..3336940 + 873 WP_242895388.1 formyltetrahydrofolate deformylase -
MF406_RS15170 (MF406_15170) 3337109..3337762 + 654 WP_242895390.1 DUF4190 domain-containing protein -
MF406_RS15175 (MF406_15175) 3337876..3338460 + 585 WP_242895392.1 HdeD family acid-resistance protein -
MF406_RS15180 (MF406_15180) 3338584..3339570 - 987 WP_242895394.1 malate dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-123)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(5-43)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 14871.22 Da        Isoelectric Point: 5.1942

>T239472 WP_242895382.1 NZ_CP094289:c3335007-3334594 [Georgenia sp. TF02-10]
VILVDTSAWVELDRATGSPVHHRLRDLVAAGDELAVTEPVIMEVLAGARDDARETSLRRLLLRFQLLSVDPTGDFEAAAR
IYRRCRAVGVTPRGIIDCLIVVVAWRWGAALLAQDVDLVRVAGVLDVPLDPATPGAR

Download         Length: 414 bp

>T239472 NZ_LR890726:c2532952-2531630 [Klebsiella pneumoniae]
ATGGCGACGCTTACCACCTGGATGAACAATGTGCGCGTGGGAACCTTAACCCGCCAGGCTAACGGGGCGCACAGTTTTCG
CTATGACGAAGAGTGGCTGCGCAGCCCGCGCGCCAGACCGCTCTCCCTCTCACTGCCGCTGCAGTATGGCAATATCACTG
CCGACGCGGTGTATCACTATTTTGATAACCTGCTGCCCGACAGCCCGCAGGTCCGCGACCGGATCGTCAGGCGCTATCAG
GCGCGCTCGAAGCAGCCGTTCGATCTGCTGGCCGAAGTCGGGCGGGATAGCGTAGGGGCGGTGACCCTCCTGCCGCCGGG
GGAAGAGGCGCACCTGGAAGGATTACGCTGGCAGACGCTGGACGAGGCGCAGCTCACCGCTTTGCTAACCGCTTACCAGT
CGGATATCCCCCTCGGGATGATTACCAGCCAGGACGATTTCCGTATCTCGGTGGCCGGCGCCCAGGAGAAAACGGCGCTG
CTGCGGATGGGCGAGCAGTGGTGTATTCCGCAGGGCGCCACGCCGACCACGCATATCATTAAGCTGCCCATCGGCGAGAT
AAAGCAGCCCAATGCAACGCTGGATCTGCGTGAAAGCGTGGATAACGAGTTTCTGTGCCTGGCGCTGGCCAGAGAACTGG
GCCTGGCGGTGCCGGAAGCGGAGATCATCACCACCCCGCGGATCCGCGCCCTGGCGGTAACCCGCTTCGACCGGCGCTGG
GCGCAGGAGGGACGGGTGCTGCTGCGTCTGCCGCAGGAGGATCTGTGTCAGGCTTTTGGTCTTCCTTCAGCGATGAAATA
TGAGTCTGACGGCGGGCCGGGTATCGCCGCGATCATGACCTTTCTGCTGGGCTCGAGTGAAGCGCTGAAAGATCGCTATG
ACTTTATGAAGTTCATGGTCTTCCAGTGGCTGACGGGGGCGACGGACGGTCACGCAAAAAACTTCTCAATTTACCTGTTG
CCCGGCGGCAGCTACCGCTTAACACCGTTCTACGACATTATTTCGGCGTTTCCGGTGCTGGGCGGCACGGGACTGCATCT
GCGCGATCTGAAGCTGTCGATGGGGCTCAATGCCACAAAAGGGCGTAAAACAGAGATTAACGCCATCTATCCGCGTCATT
TTCTGGCGACGGCCAAAGCGGTGAACTTTCCCCGGGAGCAGATGCTGGCGATCCTCCAGGAGTTTGCCGGGCATGTGCCG
CAGGCAATCGAAAGCGCTCGCCGGACGCTGCCGGCGGACTTTTCCAGCCACGTCTGGCAGGCCATTACAGAGAACATGCT
GAAGCTGCACGCCCGCCTGCAGCAAGGGCTGCAGGCGCTATAG

Antitoxin


Download         Length: 71 a.a.        Molecular weight: 7823.10 Da        Isoelectric Point: 5.8172

>AT239472 WP_242895384.1 NZ_CP094289:c3335216-3335004 [Georgenia sp. TF02-10]
MTRIRTNIEIEDTYLEIVMKRYLLRTKTEAVDLALRHLAGQPMTREEALAMEGAKAIGEVPTDVPPRGAA

Download         Length: 213 bp

>AT239472 NZ_LR890726:c2533218-2532952 [Klebsiella pneumoniae]
ATGAATTCCCCGCAGATATACAGTCCCGTGCAGCTGGCCAATTACCTGAAGCTGCTGCGCCAGCAGAACCACTGGACCCA
GGATGCGCTGGCCAGGCGGATCGGCATTAAGCAGGCCACGCTGTCCAATTTTGAAAATCACCCCGACAAAACCACCTTAA
CCACGCTGTTTAAGATCCTCCAGTCGCTGGGGGTGGTGATGACGCTGAACGCCAAAGCTGCTGAGACGGCGCCGGCTCCC
GATAACAACACGGACCTTGACTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References