Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 2828616..2829136 Replicon chromosome
Accession NZ_CP094289
Organism Georgenia sp. TF02-10

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag MF406_RS12760 Protein ID WP_242894318.1
Coordinates 2828616..2828906 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID -
Locus tag MF406_RS12765 Protein ID WP_242894321.1
Coordinates 2828903..2829136 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MF406_RS12735 (MF406_12735) 2823951..2824778 + 828 WP_242894297.1 ABC transporter permease -
MF406_RS12740 (MF406_12740) 2824851..2825633 - 783 WP_242894310.1 hypothetical protein -
MF406_RS12745 (MF406_12745) 2825636..2825803 - 168 WP_242894313.1 CopG family transcriptional regulator -
MF406_RS12750 (MF406_12750) 2825958..2827274 - 1317 WP_242894315.1 BtrH N-terminal domain-containing protein -
MF406_RS12755 (MF406_12755) 2827648..2828262 - 615 WP_242897783.1 response regulator transcription factor -
MF406_RS12760 (MF406_12760) 2828616..2828906 - 291 WP_242894318.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MF406_RS12765 (MF406_12765) 2828903..2829136 - 234 WP_242894321.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
MF406_RS12770 (MF406_12770) 2829334..2829492 - 159 WP_242894324.1 hypothetical protein -
MF406_RS12775 (MF406_12775) 2829686..2829811 - 126 Protein_2531 DNA-formamidopyrimidine glycosylase -
MF406_RS12780 (MF406_12780) 2829962..2831002 - 1041 WP_242894327.1 bifunctional DNA-formamidopyrimidine glycosylase/DNA-(apurinic or apyrimidinic site) lyase -
MF406_RS12785 (MF406_12785) 2831230..2831937 - 708 Protein_2533 ribonuclease III -
MF406_RS12790 (MF406_12790) 2831934..2832521 - 588 WP_242894330.1 YceD family protein -
MF406_RS12795 (MF406_12795) 2832772..2833275 - 504 WP_242894332.1 hypothetical protein -
MF406_RS12800 (MF406_12800) 2833272..2833805 - 534 WP_242894335.1 pantetheine-phosphate adenylyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-92)

Antitoxin

Antitoxin ParD

(1-76)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11236.60 Da        Isoelectric Point: 5.6550

>T239471 WP_242894318.1 NZ_CP094289:c2828906-2828616 [Georgenia sp. TF02-10]
VSLYRLTPAAQRDLSSIWDFTEERWDVRQAETYVAEIRAAIERVADDPGRGRACEEIREGYRRYGIGSHMLFYVENADGV
DVIRILHQRMDPTRHL

Download         Length: 291 bp

>T239471 NZ_LR890726:1834049-1834151 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8331.24 Da        Isoelectric Point: 4.5026

>AT239471 WP_242894321.1 NZ_CP094289:c2829136-2828903 [Georgenia sp. TF02-10]
MAQNTSISLDDHFSDFLARQVSSGRYRSASEVVRAALRLLEDQEAQLTALRAALVAGEESGAPEPFDFDAFVAAKKS

Download         Length: 234 bp

>AT239471 NZ_LR890726:c1834158-1834013 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References