Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 1552906..1553564 Replicon chromosome
Accession NZ_CP094289
Organism Georgenia sp. TF02-10

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag MF406_RS06995 Protein ID WP_242897227.1
Coordinates 1552906..1553322 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag MF406_RS07000 Protein ID WP_242897228.1
Coordinates 1553319..1553564 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MF406_RS06970 (MF406_06970) 1548145..1548816 - 672 WP_242897223.1 transcriptional repressor LexA -
MF406_RS06975 (MF406_06975) 1549023..1549490 + 468 WP_242897224.1 LysM peptidoglycan-binding domain-containing protein -
MF406_RS06980 (MF406_06980) 1549638..1550090 + 453 Protein_1383 transcriptional regulator NrdR -
MF406_RS06985 (MF406_06985) 1550514..1551548 - 1035 WP_242897225.1 L-glyceraldehyde 3-phosphate reductase -
MF406_RS06990 (MF406_06990) 1551608..1552828 - 1221 WP_242897226.1 phosphoglycerate dehydrogenase -
MF406_RS06995 (MF406_06995) 1552906..1553322 - 417 WP_242897227.1 type II toxin-antitoxin system VapC family toxin Toxin
MF406_RS07000 (MF406_07000) 1553319..1553564 - 246 WP_242897228.1 Arc family DNA-binding protein Antitoxin
MF406_RS07005 (MF406_07005) 1553702..1555999 - 2298 WP_242897229.1 AAA family ATPase -
MF406_RS07010 (MF406_07010) 1556230..1557267 + 1038 WP_242897230.1 PAC2 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-123)

Antitoxin

Arc-like DNA binding domain

(12-42)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15290.51 Da        Isoelectric Point: 10.5313

>T239470 WP_242897227.1 NZ_CP094289:c1553322-1552906 [Georgenia sp. TF02-10]
MIIVDTNVVSELMRPSPSPAVTSWLRQQRRDVVATTAITVAEIRYGLARLPAGRRTSRLQETAEEILDAFPRQVLPFDNA
AARLYGVIAAARERVGRPIDALDAQIAAITRSHRARLATRNTKDFEGTGVELLDPWLT

Download         Length: 417 bp

>T239470 NZ_LR890726:796377-796787 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8876.00 Da        Isoelectric Point: 4.8102

>AT239470 WP_242897228.1 NZ_CP094289:c1553564-1553319 [Georgenia sp. TF02-10]
MAAISVRDLDDDVRERLRVRAARNGRSMEAEIRHILTAAVREPEPDADLFTTLLDRFSDLGGVDLAIPARSTPARAAGFA
E

Download         Length: 246 bp

>AT239470 NZ_LR890726:796130-796396 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References