Detailed information of TA system TA239469

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazF(toxin)
• Location: 894794..895358
• Replicon: chromosome
• Accession: NZ_CP094289
• Organism: Georgenia sp. TF02-10

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: MF406_RS04035
• Protein ID: WP_242896726.1
• Coordinates: 895008..895358 (+)
• Length: 117 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: -
• Locus tag: MF406_RS04030
• Protein ID: WP_242896725.1
• Coordinates: 894794..895024 (+)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MF406_RS04010 (MF406_04010)	890068..891669	+	1602	WP_242896717.1	gamma-glutamyltransferase	-
MF406_RS04015 (MF406_04015)	891857..892078	+	222	WP_242896719.1	hypothetical protein	-
MF406_RS04020 (MF406_04020)	892517..892753	+	237	WP_242896721.1	hypothetical protein	-
MF406_RS04025 (MF406_04025)	892767..894644	+	1878	WP_242896723.1	alpha-glucosidase	-
MF406_RS04030 (MF406_04030)	894794..895024	+	231	WP_242896725.1	ribbon-helix-helix domain-containing protein	Antitoxin
MF406_RS04035 (MF406_04035)	895008..895358	+	351	WP_242896726.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
MF406_RS04040 (MF406_04040)	895651..896340	+	690	WP_242896728.1	flavodoxin/nitric oxide synthase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (1-116)

Antitoxin

• Ribbon-helix-helix protein, CopG (3-37)

Sequences

Toxin

Protein

• Length: 117 a.a.
• Molecular weight: 12587.70 Da
• Isoelectric Point: 12.0401

>T239469 WP_242896726.1 NZ_CP094289:895008-895358 [Georgenia sp. TF02-10]
MMRRGEIRLTDLDPVRGSEANKRRPAVIVSNDRANAVAERLGRGVVTIVPITSSVARIYPFQTLLPAAATGLRVDSKAQA
EQIRSVAVERIGPVVGRLPPSRMTALADAIRLHLQL

Nucleotide

• Length: 351 bp

>T239469 NZ_LR890726:340423-340791 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGCGGATGA

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 8104.81 Da
• Isoelectric Point: 4.1265

>AT239469 WP_242896725.1 NZ_CP094289:894794-895024 [Georgenia sp. TF02-10]
VKLSVSLSADEVASLDKYARATGLRSRSAVVQHAIRLLGDPDLEQDYAAAWDEWESSGESSAWDATAGDGLVDAPR

Nucleotide

• Length: 231 bp

>AT239469 NZ_LR890726:340205-340426 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA