239468

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) BrnTA/BrnT-BrnA
Location 3367..3955 Replicon plasmid pNY5301-3
Accession NZ_CP094286
Organism Acinetobacter baumannii strain NY5301

Toxin (Protein)


Gene name brnT Uniprot ID A0A3G6Z3M6
Locus tag MQE20_RS20800 Protein ID WP_000438826.1
Coordinates 3367..3654 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name brnA Uniprot ID N9M5I3
Locus tag MQE20_RS20805 Protein ID WP_001983304.1
Coordinates 3641..3955 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MQE20_RS20780 (MQE20_20780) 606..1556 + 951 WP_001205343.1 replication initiation protein RepM -
MQE20_RS20785 (MQE20_20785) 1549..2124 + 576 WP_001096616.1 plasmid replication DNA-binding protein -
MQE20_RS20790 (MQE20_20790) 2144..2287 + 144 WP_001125246.1 hypothetical protein -
MQE20_RS20795 (MQE20_20795) 2476..2994 - 519 WP_000447193.1 tetratricopeptide repeat protein -
MQE20_RS20800 (MQE20_20800) 3367..3654 + 288 WP_000438826.1 BrnT family toxin Toxin
MQE20_RS20805 (MQE20_20805) 3641..3955 + 315 WP_001983304.1 BrnA antitoxin family protein Antitoxin
MQE20_RS20810 (MQE20_20810) 4083..6494 + 2412 Protein_6 TonB-dependent receptor ZnuD2 -
MQE20_RS20815 (MQE20_20815) 6799..7260 + 462 WP_000761346.1 DIP1984 family protein -
MQE20_RS20820 (MQE20_20820) 7583..7756 - 174 WP_001282484.1 hypothetical protein -
MQE20_RS20825 (MQE20_20825) 7756..8127 - 372 WP_000504218.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..8731 8731


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(41-96)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11303.72 Da        Isoelectric Point: 6.0889

>T239468 WP_000438826.1 NZ_CP094286:3367-3654 [Acinetobacter baumannii]
MEQYFEWDEAKNRKNQKKHDISFETASLVFEDPLRISIQDRHTNGEERWQTIGRVKGVLMLLVAHTIFDEDDCEIIRIIS
ARQVTKAERNKYEHG

Download         Length: 288 bp

>T239468 NZ_LR890726:208563-209048 [Klebsiella pneumoniae]
GTGGGACGTATAACCGCGCCCGAGCCGTTATCCAGCGCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTCGA
TGAATGGCTAAAACAGAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGAAGGGTACGA
AGCAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGCGTTAACCATACGGAAGCGACAGGCAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCGCGGAAAAGGGCTTGGCGCTGATTT
ACTTCATGATGCAGTACTTCGTTGCTATCGGGTTGCCGAGAATATAGGTGTACGTGCAATCATGGTTCATGCGCTCACAG
AAGAAGCCAAAAATTTCTACATTCACCATGGTTTCAAACCATCACAAACTCAGCCGCGGACACTGTTCCTCAGACTCCCT
CAGTAA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12208.84 Da        Isoelectric Point: 7.2026

>AT239468 WP_001983304.1 NZ_CP094286:3641-3955 [Acinetobacter baumannii]
MSMVRYSHKELNEKFGEKQDAEIQRLLAKGTVPDDQLDLSDIPEITDWSNAVRQNQFYRPVKQQTSIRLDADVLAWFKAQ
GKGYQTRMNEILRDAMLKELKNHQ

Download         Length: 315 bp

>AT239468 NZ_LR890726:208309-208575 [Klebsiella pneumoniae]
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGAGCACTCATCGATGCCGCTGCAGAGATCCTTCA
TAAATCGCGAACCGACTTTATCCTGGAGATGGCCTGCAAGGCTGCGGAGAATGTGATCCTTGATCGCCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGAGCCCGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGACGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G6Z3M6

Antitoxin

Source ID Structure
AlphaFold DB N9M5I3

References