Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/HicA-HicB |
| Location | 2284557..2285236 | Replicon | chromosome |
| Accession | NZ_CP094283 | ||
| Organism | Acinetobacter baumannii strain NY5301 | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | S3TWT7 |
| Locus tag | MQE20_RS11055 | Protein ID | WP_000838146.1 |
| Coordinates | 2285054..2285236 (-) | Length | 61 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | N9L2H6 |
| Locus tag | MQE20_RS11050 | Protein ID | WP_000966688.1 |
| Coordinates | 2284557..2284961 (-) | Length | 135 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MQE20_RS11020 (MQE20_11020) | 2281569..2282561 | - | 993 | WP_000835645.1 | KilA-N domain-containing protein | - |
| MQE20_RS11025 (MQE20_11025) | 2282558..2282713 | - | 156 | WP_001103649.1 | Arc family DNA-binding protein | - |
| MQE20_RS11030 (MQE20_11030) | 2282836..2283075 | + | 240 | WP_000763623.1 | Arc family DNA-binding protein | - |
| MQE20_RS11035 (MQE20_11035) | 2283124..2283918 | - | 795 | WP_000720608.1 | hypothetical protein | - |
| MQE20_RS11040 (MQE20_11040) | 2283950..2284273 | - | 324 | WP_000523922.1 | DUF4236 domain-containing protein | - |
| MQE20_RS11045 (MQE20_11045) | 2284282..2284458 | - | 177 | WP_014466185.1 | hypothetical protein | - |
| MQE20_RS11050 (MQE20_11050) | 2284557..2284961 | - | 405 | WP_000966688.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| MQE20_RS11055 (MQE20_11055) | 2285054..2285236 | - | 183 | WP_000838146.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| MQE20_RS11060 (MQE20_11060) | 2285562..2286077 | - | 516 | WP_001185608.1 | hypothetical protein | - |
| MQE20_RS11065 (MQE20_11065) | 2286147..2287064 | - | 918 | WP_000094250.1 | phage tail tube protein | - |
| MQE20_RS11070 (MQE20_11070) | 2287117..2288352 | - | 1236 | WP_000002422.1 | hypothetical protein | - |
| MQE20_RS11075 (MQE20_11075) | 2288352..2288705 | - | 354 | WP_000064599.1 | hypothetical protein | - |
| MQE20_RS11080 (MQE20_11080) | 2288799..2289017 | - | 219 | WP_001277687.1 | hypothetical protein | - |
| MQE20_RS11085 (MQE20_11085) | 2289019..2289417 | - | 399 | WP_001251850.1 | phage tail terminator-like protein | - |
| MQE20_RS11090 (MQE20_11090) | 2289419..2289787 | - | 369 | WP_002055488.1 | hypothetical protein | - |
| MQE20_RS11095 (MQE20_11095) | 2289759..2290163 | - | 405 | WP_000247948.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | plc | 2129438..2427330 | 297892 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 61 a.a. Molecular weight: 6695.84 Da Isoelectric Point: 10.5523
>T239466 WP_000838146.1 NZ_CP094283:c2285236-2285054 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN
Download Length: 183 bp
>T239466 NZ_LR890723:53790-54272 [Klebsiella pneumoniae]
GTGGGACGTATAACCACGCCCGAGCCGTTATCCAGCTCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTCGA
TGAATGGCTAAAACAGAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGACGGGTACGA
AGCAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGCGTTAACCATACGGAAGCGACAGGTAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCACGGAAAAGGGGTTGGCGCCGATTT
ACTCCACGATGCAGTTCTACGGTGTTATCGCGTAGCTGAGAACATTGGGGTTCGTGCGATAATGGTTCATGCGCTTACTG
AAGAAGCCAAAGGTTTCTATGCTCACCATGGATTTAAGGCATCACAAACTCATGAGAGGACTCTGTTTCTAAAGCTTCCA
TGA
GTGGGACGTATAACCACGCCCGAGCCGTTATCCAGCTCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTCGA
TGAATGGCTAAAACAGAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGACGGGTACGA
AGCAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGCGTTAACCATACGGAAGCGACAGGTAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCACGGAAAAGGGGTTGGCGCCGATTT
ACTCCACGATGCAGTTCTACGGTGTTATCGCGTAGCTGAGAACATTGGGGTTCGTGCGATAATGGTTCATGCGCTTACTG
AAGAAGCCAAAGGTTTCTATGCTCACCATGGATTTAAGGCATCACAAACTCATGAGAGGACTCTGTTTCTAAAGCTTCCA
TGA
Antitoxin
Download Length: 135 a.a. Molecular weight: 14647.69 Da Isoelectric Point: 4.4328
>AT239466 WP_000966688.1 NZ_CP094283:c2284961-2284557 [Acinetobacter baumannii]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA
Download Length: 405 bp
>AT239466 NZ_LR890723:53536-53802 [Klebsiella pneumoniae]
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGAGCACTCATCGATGCTGCTGCAGAGATCCTTCA
TAAATCGCGAACCGACTTTATCCTGGAGATGGCCTGCAAGGCTGCGGAGAATGTGATCCTTGATCGCCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGAGCCCGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGACGTATAA
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGAGCACTCATCGATGCTGCTGCAGAGATCCTTCA
TAAATCGCGAACCGACTTTATCCTGGAGATGGCCTGCAAGGCTGCGGAGAATGTGATCCTTGATCGCCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGAGCCCGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGACGTATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|