Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/HicA-HicB |
| Location | 2233934..2234613 | Replicon | chromosome |
| Accession | NZ_CP094283 | ||
| Organism | Acinetobacter baumannii strain NY5301 | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | S3TWT7 |
| Locus tag | MQE20_RS10675 | Protein ID | WP_000838146.1 |
| Coordinates | 2234431..2234613 (-) | Length | 61 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | N9L2H6 |
| Locus tag | MQE20_RS10670 | Protein ID | WP_000966688.1 |
| Coordinates | 2233934..2234338 (-) | Length | 135 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MQE20_RS10640 (MQE20_10640) | 2230946..2231938 | - | 993 | WP_000835645.1 | KilA-N domain-containing protein | - |
| MQE20_RS10645 (MQE20_10645) | 2231935..2232090 | - | 156 | WP_001103649.1 | Arc family DNA-binding protein | - |
| MQE20_RS10650 (MQE20_10650) | 2232213..2232452 | + | 240 | WP_000763623.1 | Arc family DNA-binding protein | - |
| MQE20_RS10655 (MQE20_10655) | 2232501..2233295 | - | 795 | WP_000720608.1 | hypothetical protein | - |
| MQE20_RS10660 (MQE20_10660) | 2233327..2233650 | - | 324 | WP_000523922.1 | DUF4236 domain-containing protein | - |
| MQE20_RS10665 (MQE20_10665) | 2233659..2233835 | - | 177 | WP_014466185.1 | hypothetical protein | - |
| MQE20_RS10670 (MQE20_10670) | 2233934..2234338 | - | 405 | WP_000966688.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| MQE20_RS10675 (MQE20_10675) | 2234431..2234613 | - | 183 | WP_000838146.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| MQE20_RS10680 (MQE20_10680) | 2234939..2235454 | - | 516 | WP_001185608.1 | hypothetical protein | - |
| MQE20_RS10685 (MQE20_10685) | 2235524..2236441 | - | 918 | WP_000094250.1 | phage tail tube protein | - |
| MQE20_RS10690 (MQE20_10690) | 2236494..2237729 | - | 1236 | WP_000002422.1 | hypothetical protein | - |
| MQE20_RS10695 (MQE20_10695) | 2237729..2238082 | - | 354 | WP_000064599.1 | hypothetical protein | - |
| MQE20_RS10700 (MQE20_10700) | 2238176..2238394 | - | 219 | WP_001277687.1 | hypothetical protein | - |
| MQE20_RS10705 (MQE20_10705) | 2238396..2238794 | - | 399 | WP_001251850.1 | phage tail terminator-like protein | - |
| MQE20_RS10710 (MQE20_10710) | 2238796..2239164 | - | 369 | WP_002055488.1 | hypothetical protein | - |
| MQE20_RS10715 (MQE20_10715) | 2239136..2239540 | - | 405 | WP_000247948.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | plc | 2129438..2427330 | 297892 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 61 a.a. Molecular weight: 6695.84 Da Isoelectric Point: 10.5523
>T239465 WP_000838146.1 NZ_CP094283:c2234613-2234431 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN
Download Length: 183 bp
>T239465 NZ_LR890722:c5152478-5152095 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGCCACGCCGTACGAAATCCACCCTGAATAA
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGCCACGCCGTACGAAATCCACCCTGAATAA
Antitoxin
Download Length: 135 a.a. Molecular weight: 14647.69 Da Isoelectric Point: 4.4328
>AT239465 WP_000966688.1 NZ_CP094283:c2234338-2233934 [Acinetobacter baumannii]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA
Download Length: 405 bp
>AT239465 NZ_LR890722:c5152720-5152478 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|