Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4622801..4623317 Replicon chromosome
Accession NZ_CP094280
Organism Klebsiella aerogenes strain NY1464

Toxin (Protein)


Gene name relE Uniprot ID A0A837JS79
Locus tag MQE09_RS22090 Protein ID WP_045378458.1
Coordinates 4622801..4623085 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag MQE09_RS22095 Protein ID WP_002886901.1
Coordinates 4623075..4623317 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MQE09_RS22070 (4618216) 4618216..4618524 - 309 WP_020079792.1 PTS sugar transporter subunit IIB -
MQE09_RS22075 (4618786) 4618786..4619529 + 744 WP_015704205.1 MurR/RpiR family transcriptional regulator -
MQE09_RS22080 (4619887) 4619887..4622025 + 2139 WP_015368566.1 anaerobic ribonucleoside-triphosphate reductase -
MQE09_RS22085 (4622333) 4622333..4622797 + 465 WP_015368567.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
MQE09_RS22090 (4622801) 4622801..4623085 - 285 WP_045378458.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MQE09_RS22095 (4623075) 4623075..4623317 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
MQE09_RS22100 (4623395) 4623395..4625305 - 1911 WP_047040166.1 PRD domain-containing protein -
MQE09_RS22105 (4625328) 4625328..4626479 - 1152 WP_047040164.1 lactonase family protein -
MQE09_RS22110 (4626546) 4626546..4627286 - 741 WP_020079796.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11145.05 Da        Isoelectric Point: 10.3787

>T239462 WP_045378458.1 NZ_CP094280:c4623085-4622801 [Klebsiella aerogenes]
MTYELEFDPRAWREWQKLGETVKKQFKNKLLQIVQNPRMESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T239462 NZ_LR890722:c4572123-4571590 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCAGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGCGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAGGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT239462 WP_002886901.1 NZ_CP094280:c4623317-4623075 [Klebsiella aerogenes]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT239462 NZ_LR890722:c4572400-4572134 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837JS79

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References