Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3888762..3889381 Replicon chromosome
Accession NZ_CP094280
Organism Klebsiella aerogenes strain NY1464

Toxin (Protein)


Gene name Hha Uniprot ID A0A0H3FXE2
Locus tag MQE09_RS18725 Protein ID WP_015367918.1
Coordinates 3889163..3889381 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A837JQD8
Locus tag MQE09_RS18720 Protein ID WP_045381144.1
Coordinates 3888762..3889136 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MQE09_RS18710 (3883917) 3883917..3885116 + 1200 WP_020079451.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
MQE09_RS18715 (3885139) 3885139..3888285 + 3147 WP_015704610.1 multidrug efflux RND transporter permease subunit AcrB -
MQE09_RS18720 (3888762) 3888762..3889136 + 375 WP_045381144.1 Hha toxicity modulator TomB Antitoxin
MQE09_RS18725 (3889163) 3889163..3889381 + 219 WP_015367918.1 HHA domain-containing protein Toxin
MQE09_RS18730 (3889513) 3889513..3890076 + 564 WP_045381141.1 maltose O-acetyltransferase -
MQE09_RS18735 (3890051) 3890051..3890155 - 105 Protein_3675 hypothetical protein -
MQE09_RS18740 (3890202) 3890202..3890666 + 465 WP_015367920.1 YlaC family protein -
MQE09_RS18745 (3890641) 3890641..3892095 - 1455 WP_045381138.1 PLP-dependent aminotransferase family protein -
MQE09_RS18750 (3892198) 3892198..3892908 + 711 WP_045381136.1 GNAT family protein -
MQE09_RS18755 (3892905) 3892905..3893045 - 141 WP_003859006.1 type B 50S ribosomal protein L36 -
MQE09_RS18760 (3893048) 3893048..3893308 - 261 WP_015367923.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8569.96 Da        Isoelectric Point: 9.4828

>T239461 WP_015367918.1 NZ_CP094280:3889163-3889381 [Klebsiella aerogenes]
MSGKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T239461 NZ_LR890722:3971606-3971824 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14519.28 Da        Isoelectric Point: 4.9045

>AT239461 WP_045381144.1 NZ_CP094280:3888762-3889136 [Klebsiella aerogenes]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNRGWVNDPTSAVNLQLNELIEHIATYALNYKIKYAEDNKLISQLDEYL
DDTFMLFSSYGINTNDLQKWRKSGNRLFRCFVNASRENPVSLSC

Download         Length: 375 bp

>AT239461 NZ_LR890722:3971205-3971579 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAACTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3FXE2

Antitoxin

Source ID Structure
AlphaFold DB A0A837JQD8

References