Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 3339474..3340112 Replicon chromosome
Accession NZ_CP094280
Organism Klebsiella aerogenes strain NY1464

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag MQE09_RS16145 Protein ID WP_047043763.1
Coordinates 3339474..3339656 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag MQE09_RS16150 Protein ID WP_047056232.1
Coordinates 3339681..3340112 (+) Length 144 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MQE09_RS16105 (3335266) 3335266..3335700 - 435 WP_224108052.1 P27 family phage terminase small subunit -
MQE09_RS16110 (3335890) 3335890..3336321 - 432 WP_162866848.1 hypothetical protein -
MQE09_RS16115 (3336318) 3336318..3336668 - 351 WP_224108053.1 hypothetical protein -
MQE09_RS16120 (3336629) 3336629..3336991 - 363 WP_047465132.1 HNH endonuclease signature motif containing protein -
MQE09_RS16125 (3336991) 3336991..3337278 - 288 WP_224108054.1 hypothetical protein -
MQE09_RS26340 (3337287) 3337287..3337409 + 123 WP_257850964.1 hypothetical protein -
MQE09_RS16130 (3337948) 3337948..3338460 - 513 WP_047056238.1 DUF2514 domain-containing protein -
MQE09_RS16135 (3338457) 3338457..3338990 - 534 WP_015367388.1 lysozyme -
MQE09_RS16140 (3338992) 3338992..3339240 - 249 WP_047056234.1 phage holin -
MQE09_RS16145 (3339474) 3339474..3339656 + 183 WP_047043763.1 type II toxin-antitoxin system HicA family toxin Toxin
MQE09_RS16150 (3339681) 3339681..3340112 + 432 WP_047056232.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
MQE09_RS16155 (3340216) 3340216..3340503 + 288 WP_032708407.1 hypothetical protein -
MQE09_RS16160 (3340553) 3340553..3340981 + 429 WP_086630890.1 hypothetical protein -
MQE09_RS16165 (3341205) 3341205..3341807 - 603 WP_224108173.1 hypothetical protein -
MQE09_RS16170 (3341821) 3341821..3342852 - 1032 WP_224108055.1 DUF968 domain-containing protein -
MQE09_RS16175 (3342852) 3342852..3343055 - 204 WP_015367393.1 hypothetical protein -
MQE09_RS16180 (3343052) 3343052..3343444 - 393 WP_224108056.1 DNA-binding protein -
MQE09_RS16185 (3343787) 3343787..3344020 - 234 WP_224108057.1 DinI family protein -
MQE09_RS16190 (3344328) 3344328..3344690 + 363 WP_047043775.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 3308976..3355922 46946


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-60)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(7-137)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6508.74 Da        Isoelectric Point: 10.8930

>T239460 WP_047043763.1 NZ_CP094280:3339474-3339656 [Klebsiella aerogenes]
MKSTDLIKELIAAGCELKRQGKGSHQIWWSPITGKTFPVPHPKGNLPIGTIKSIKKTAGI

Download         Length: 183 bp

>T239460 NZ_LR890722:c2607946-2606624 [Klebsiella pneumoniae]
ATGGCGACGCTTACCACCTGGATGAACAATGTGCGCGTGGGAACCTTAACCCGCCAGGCTAACGGGGCGCACAGTTTTCG
CTATGACGAAGAGTGGCTGCGCAGCCCGCGCGCCAGACCGCTCTCCCTCTCACTGCCGCTGCAGTATGGCAATATCACTG
CCGACGCGGTGTATCACTATTTTGATAACCTGCTGCCCGACAGCCCGCAGGTCCGCGACCGGATCGTCAGGCGCTATCAG
GCGCGCTCGAAGCAGCCGTTCGATCTGCTGGCCGAAGTCGGGCGGGATAGCGTAGGGGCGGTGACCCTCCTGCCGCCGGG
GGAAGAGGCGCACCTGGAAGGATTACGCTGGCAGACGCTGGACGAGGCGCAGCTCACCGCTTTGCTGACCGCTTACCAGT
CGGATATCCCCCTCGGGATGATTACCAGCCAGGACGATTTCCGTATCTCGGTGGCCGGCGCCCAGGAGAAAACGGCGCTG
CTGCGGATGGGCGAGCAGTGGTGTATTCCGCAGGGCGCCACGCCGACCACGCATATCATTAAGCTGCCCATCGGCGAGAT
CAAGCAGCCCAATGCGACGCTGGATCTGCGTGAAAGCGTGGATAATGAGTTTCTGTGCCTGGCGCTGGCCAGAGAACTGG
GCCTGGCGGTGCCGGAAGCGGAGATCATCACCACCCCGCGGATCCGCGCCCTGGCGGTAACCCGCTTCGACCGGCGCTGG
GCGCAGGAGGGACGGGTGCTGCTGCGTCTGCCGCAGGAGGATCTGTGTCAGGCTTTTGGTCTTCCTTCAGCGATGAAATA
TGAGTCTGACGGCGGGCCGGGTATCGCCGCGATCATGACCTTTCTGCTGGGCTCGAGTGAAGCGCTGAAAGATCGCTATG
ACTTTATGAAGTTCATGGTCTTCCAGTGGCTGACGGGGGCGACGGACGGTCACGCAAAAAACTTCTCAATTTACCTGTTG
CCCGGCGGCAGCTACCGCTTAACACCGTTCTACGACATTATTTCGGCGTTTCCGGTGCTGGGCGGCACGGGACTGCATCT
GCGCGATCTGAAGCTGTCGATGGGGCTCAATGCCACAAAAGGGCGTAAAACAGAGATTAACGCCATCTATCCGCGTCATT
TTCTGGCGACGGCCAAAGCGGTGAACTTTCCCCGGGAGCAGATGCTGGCGATCCTCCAGGAGTTTGCCGGGCATGTGCCG
CAGGCAATCGAAAGCGCTCGCCGGACGCTGCCGGCGGACTTTTCCAGCCACGTCTGGCAGGCCATTACAGAGAACATGCT
GAAGCTGCACGCCCGCCTGCAGCAAGGGCTGCAGGCGCTATAG

Antitoxin


Download         Length: 144 a.a.        Molecular weight: 15972.02 Da        Isoelectric Point: 4.2696

>AT239460 WP_047056232.1 NZ_CP094280:3339681-3340112 [Klebsiella aerogenes]
MFFSVGVETPKDENTAYGMIVPAFSAYEMGCFSAADTQDQIAPMVKEAILLSVECLIEDAGRSVDEIKDAGYMVYAANPE
YKDFDSWFMVEVDLSEFEGKPQRINISLPDTLIKRIDNAVKGNASYRDRSHFLAEAARHELKG

Download         Length: 432 bp

>AT239460 NZ_LR890722:c2608212-2607946 [Klebsiella pneumoniae]
ATGAATTCCCCGCAGATATACAGTCCCGTGCAGCTGGCCAATTACCTGAAGCTGCTGCGCCAGCAGAACCACTGGACCCA
GGATGCGCTGGCCAGGCGGATCGGCATTAAGCAGGCCACGCTGTCCAATTTTGAAAATCACCCCGACAAAACCACCTTAA
CCACGCTGTTTAAGATCCTCCAGTCGCTGGGGGTGGTGATGACGCTGAACGCCAAAGCTGCTGAGACGGCGCCGGCTCCC
GATAACAACACGGACCTTGACTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References