Detailed information of TA system TA239460

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 3339474..3340112
• Replicon: chromosome
• Accession: NZ_CP094280
• Organism: Klebsiella aerogenes strain NY1464

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: MQE09_RS16145
• Protein ID: WP_047043763.1
• Coordinates: 3339474..3339656 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: MQE09_RS16150
• Protein ID: WP_047056232.1
• Coordinates: 3339681..3340112 (+)
• Length: 144 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MQE09_RS16105 (3335266)	3335266..3335700	-	435	WP_224108052.1	P27 family phage terminase small subunit	-
MQE09_RS16110 (3335890)	3335890..3336321	-	432	WP_162866848.1	hypothetical protein	-
MQE09_RS16115 (3336318)	3336318..3336668	-	351	WP_224108053.1	hypothetical protein	-
MQE09_RS16120 (3336629)	3336629..3336991	-	363	WP_047465132.1	HNH endonuclease signature motif containing protein	-
MQE09_RS16125 (3336991)	3336991..3337278	-	288	WP_224108054.1	hypothetical protein	-
MQE09_RS26340 (3337287)	3337287..3337409	+	123	WP_257850964.1	hypothetical protein	-
MQE09_RS16130 (3337948)	3337948..3338460	-	513	WP_047056238.1	DUF2514 domain-containing protein	-
MQE09_RS16135 (3338457)	3338457..3338990	-	534	WP_015367388.1	lysozyme	-
MQE09_RS16140 (3338992)	3338992..3339240	-	249	WP_047056234.1	phage holin	-
MQE09_RS16145 (3339474)	3339474..3339656	+	183	WP_047043763.1	type II toxin-antitoxin system HicA family toxin	Toxin
MQE09_RS16150 (3339681)	3339681..3340112	+	432	WP_047056232.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
MQE09_RS16155 (3340216)	3340216..3340503	+	288	WP_032708407.1	hypothetical protein	-
MQE09_RS16160 (3340553)	3340553..3340981	+	429	WP_086630890.1	hypothetical protein	-
MQE09_RS16165 (3341205)	3341205..3341807	-	603	WP_224108173.1	hypothetical protein	-
MQE09_RS16170 (3341821)	3341821..3342852	-	1032	WP_224108055.1	DUF968 domain-containing protein	-
MQE09_RS16175 (3342852)	3342852..3343055	-	204	WP_015367393.1	hypothetical protein	-
MQE09_RS16180 (3343052)	3343052..3343444	-	393	WP_224108056.1	DNA-binding protein	-
MQE09_RS16185 (3343787)	3343787..3344020	-	234	WP_224108057.1	DinI family protein	-
MQE09_RS16190 (3344328)	3344328..3344690	+	363	WP_047043775.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	3308976..3355922	46946

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-60)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (7-137)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6508.74 Da
• Isoelectric Point: 10.8930

>T239460 WP_047043763.1 NZ_CP094280:3339474-3339656 [Klebsiella aerogenes]
MKSTDLIKELIAAGCELKRQGKGSHQIWWSPITGKTFPVPHPKGNLPIGTIKSIKKTAGI

Nucleotide

• Length: 183 bp

>T239460 NZ_LR890722:c2607946-2606624 [Klebsiella pneumoniae]
ATGGCGACGCTTACCACCTGGATGAACAATGTGCGCGTGGGAACCTTAACCCGCCAGGCTAACGGGGCGCACAGTTTTCG
CTATGACGAAGAGTGGCTGCGCAGCCCGCGCGCCAGACCGCTCTCCCTCTCACTGCCGCTGCAGTATGGCAATATCACTG
CCGACGCGGTGTATCACTATTTTGATAACCTGCTGCCCGACAGCCCGCAGGTCCGCGACCGGATCGTCAGGCGCTATCAG
GCGCGCTCGAAGCAGCCGTTCGATCTGCTGGCCGAAGTCGGGCGGGATAGCGTAGGGGCGGTGACCCTCCTGCCGCCGGG
GGAAGAGGCGCACCTGGAAGGATTACGCTGGCAGACGCTGGACGAGGCGCAGCTCACCGCTTTGCTGACCGCTTACCAGT
CGGATATCCCCCTCGGGATGATTACCAGCCAGGACGATTTCCGTATCTCGGTGGCCGGCGCCCAGGAGAAAACGGCGCTG
CTGCGGATGGGCGAGCAGTGGTGTATTCCGCAGGGCGCCACGCCGACCACGCATATCATTAAGCTGCCCATCGGCGAGAT
CAAGCAGCCCAATGCGACGCTGGATCTGCGTGAAAGCGTGGATAATGAGTTTCTGTGCCTGGCGCTGGCCAGAGAACTGG
GCCTGGCGGTGCCGGAAGCGGAGATCATCACCACCCCGCGGATCCGCGCCCTGGCGGTAACCCGCTTCGACCGGCGCTGG
GCGCAGGAGGGACGGGTGCTGCTGCGTCTGCCGCAGGAGGATCTGTGTCAGGCTTTTGGTCTTCCTTCAGCGATGAAATA
TGAGTCTGACGGCGGGCCGGGTATCGCCGCGATCATGACCTTTCTGCTGGGCTCGAGTGAAGCGCTGAAAGATCGCTATG
ACTTTATGAAGTTCATGGTCTTCCAGTGGCTGACGGGGGCGACGGACGGTCACGCAAAAAACTTCTCAATTTACCTGTTG
CCCGGCGGCAGCTACCGCTTAACACCGTTCTACGACATTATTTCGGCGTTTCCGGTGCTGGGCGGCACGGGACTGCATCT
GCGCGATCTGAAGCTGTCGATGGGGCTCAATGCCACAAAAGGGCGTAAAACAGAGATTAACGCCATCTATCCGCGTCATT
TTCTGGCGACGGCCAAAGCGGTGAACTTTCCCCGGGAGCAGATGCTGGCGATCCTCCAGGAGTTTGCCGGGCATGTGCCG
CAGGCAATCGAAAGCGCTCGCCGGACGCTGCCGGCGGACTTTTCCAGCCACGTCTGGCAGGCCATTACAGAGAACATGCT
GAAGCTGCACGCCCGCCTGCAGCAAGGGCTGCAGGCGCTATAG

Antitoxin

Protein

• Length: 144 a.a.
• Molecular weight: 15972.02 Da
• Isoelectric Point: 4.2696

>AT239460 WP_047056232.1 NZ_CP094280:3339681-3340112 [Klebsiella aerogenes]
MFFSVGVETPKDENTAYGMIVPAFSAYEMGCFSAADTQDQIAPMVKEAILLSVECLIEDAGRSVDEIKDAGYMVYAANPE
YKDFDSWFMVEVDLSEFEGKPQRINISLPDTLIKRIDNAVKGNASYRDRSHFLAEAARHELKG

Nucleotide

• Length: 432 bp

>AT239460 NZ_LR890722:c2608212-2607946 [Klebsiella pneumoniae]
ATGAATTCCCCGCAGATATACAGTCCCGTGCAGCTGGCCAATTACCTGAAGCTGCTGCGCCAGCAGAACCACTGGACCCA
GGATGCGCTGGCCAGGCGGATCGGCATTAAGCAGGCCACGCTGTCCAATTTTGAAAATCACCCCGACAAAACCACCTTAA
CCACGCTGTTTAAGATCCTCCAGTCGCTGGGGGTGGTGATGACGCTGAACGCCAAAGCTGCTGAGACGGCGCCGGCTCCC
GATAACAACACGGACCTTGACTGGTAA