Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ypjF-yeeU/CbtA-CbeA
Location 1180095..1180821 Replicon chromosome
Accession NZ_CP094280
Organism Klebsiella aerogenes strain NY1464

Toxin (Protein)


Gene name ypjF Uniprot ID -
Locus tag MQE09_RS05830 Protein ID WP_224108451.1
Coordinates 1180095..1180424 (-) Length 110 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag MQE09_RS05835 Protein ID WP_042893201.1
Coordinates 1180462..1180821 (-) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MQE09_RS05795 (1175107) 1175107..1175430 - 324 WP_032712345.1 contact-dependent growth inhibition system immunity protein -
MQE09_RS05800 (1175513) 1175513..1175653 - 141 WP_161799855.1 contact-dependent growth inhibition system immunity protein -
MQE09_RS05805 (1175944) 1175944..1176171 + 228 WP_072059324.1 DUF1272 domain-containing protein -
MQE09_RS05810 (1176521) 1176521..1177639 + 1119 WP_047038912.1 aspartate-semialdehyde dehydrogenase -
MQE09_RS05815 (1177863) 1177863..1178399 + 537 WP_047038905.1 dihydrofolate reductase family protein -
MQE09_RS05820 (1178576) 1178576..1179376 + 801 WP_047038900.1 nucleotidyltransferase domain-containing protein -
MQE09_RS05825 (1179597) 1179597..1179698 - 102 Protein_1141 preprotein translocase -
MQE09_RS05830 (1180095) 1180095..1180424 - 330 WP_224108451.1 TA system toxin CbtA family protein Toxin
MQE09_RS05835 (1180462) 1180462..1180821 - 360 WP_042893201.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
MQE09_RS05840 (1180844) 1180844..1181065 - 222 WP_042893203.1 DUF987 domain-containing protein -
MQE09_RS05845 (1181080) 1181080..1181559 - 480 WP_042893205.1 DNA repair protein RadC -
MQE09_RS05850 (1181571) 1181571..1181966 - 396 WP_045341441.1 antirestriction protein -
MQE09_RS05855 (1181982) 1181982..1182236 - 255 WP_072035668.1 hypothetical protein -
MQE09_RS05860 (1182236) 1182236..1183054 - 819 WP_042893207.1 DUF932 domain-containing protein -
MQE09_RS05865 (1183152) 1183152..1183385 - 234 WP_042893208.1 DUF905 family protein -
MQE09_RS05870 (1183479) 1183479..1184315 - 837 WP_042893210.1 hypothetical protein -
MQE09_RS05875 (1184373) 1184373..1184618 - 246 WP_042893213.1 hypothetical protein -
MQE09_RS05880 (1184618) 1184618..1184845 - 228 WP_042893214.1 hypothetical protein -
MQE09_RS05885 (1184918) 1184918..1185325 - 408 WP_042893215.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1175107..1214456 39349


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-108)

Antitoxin

Antitoxin CbeA

(15-115)


Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12338.03 Da        Isoelectric Point: 9.5927

>T239450 WP_224108451.1 NZ_CP094280:c1180424-1180095 [Klebsiella aerogenes]
MQTLSSHSTRATQPNLSPVKTWQLLLTHLLSQHYGLTLNDTPFSDETTIQEHIDAGISLSNAVNFLVEKYGLVRIDRKGF
SWQEQTPYLSVVDILRARRSTGLLKTNVK

Download         Length: 330 bp

>T239450 NZ_LR890719:c4625590-4625306 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13412.23 Da        Isoelectric Point: 5.8752

>AT239450 WP_042893201.1 NZ_CP094280:c1180821-1180462 [Klebsiella aerogenes]
MQNTTPVANHDIAEPWWGLKPTVTPCLGARLVQEGNRLHYLADPASITGTFNNEDLRHLDQAFPVLLKQLELMLVSGELT
SRYQHRITLYHNRLTCEADTLGSCGYVCIAIYPDQPEPH

Download         Length: 360 bp

>AT239450 NZ_LR890719:c4625822-4625580 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References