Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 864477..865134 Replicon chromosome
Accession NZ_CP094280
Organism Klebsiella aerogenes strain NY1464

Toxin (Protein)


Gene name cptA Uniprot ID A0A0H3FM52
Locus tag MQE09_RS04285 Protein ID WP_015369792.1
Coordinates 864724..865134 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A0H3FJK6
Locus tag MQE09_RS04280 Protein ID WP_015369791.1
Coordinates 864477..864743 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MQE09_RS04255 (859704) 859704..861137 - 1434 WP_049057854.1 6-phospho-beta-glucosidase BglA -
MQE09_RS04260 (861251) 861251..861985 - 735 WP_015703423.1 MurR/RpiR family transcriptional regulator -
MQE09_RS04265 (862036) 862036..862347 + 312 WP_045374015.1 N(4)-acetylcytidine aminohydrolase -
MQE09_RS04270 (862512) 862512..863171 + 660 WP_008806429.1 hemolysin III family protein -
MQE09_RS04275 (863270) 863270..864253 - 984 WP_045374012.1 tRNA-modifying protein YgfZ -
MQE09_RS04280 (864477) 864477..864743 + 267 WP_015369791.1 FAD assembly factor SdhE Antitoxin
MQE09_RS04285 (864724) 864724..865134 + 411 WP_015369792.1 protein YgfX Toxin
MQE09_RS04290 (865142) 865142..865663 - 522 WP_045374009.1 flavodoxin FldB -
MQE09_RS04295 (865764) 865764..866660 + 897 WP_224108507.1 site-specific tyrosine recombinase XerD -
MQE09_RS04300 (866683) 866683..867396 + 714 WP_045374003.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
MQE09_RS04305 (867402) 867402..869135 + 1734 WP_047039260.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 15887.69 Da        Isoelectric Point: 10.0200

>T239449 WP_015369792.1 NZ_CP094280:864724-865134 [Klebsiella aerogenes]
VVLWQSDLRISWRSQWFSLLLHGVVAAIVLLMPWPLSYTPIWLLLLSLVVFDCVRSQRRIHACQGEIKLLIDSRLRWQKT
EWDIVGTPWVISSGMLLRLKHAETGRSQHLWVAADSMDAGEWRDLRRLVLQKPAHD

Download         Length: 411 bp

>T239449 NZ_LR890719:c4545873-4545532 [Klebsiella pneumoniae]
ATGAATACTTTACCTGCAATAAACCAGCGGGCTGTTCAGACATGTTTATCACCCGTGGTTGTCTGGCAAATGCTGCTTGC
TCGACTACTTGAACAGCATTATGGCCTGACCTTAAATGACACGCCGTTCAGCGATGAGGCTGTTATTAAAAGACATATCG
AAGCTGGTATCACGCTTGTCGATGCCGTTAATTTTCTGCTGGAAAACTACGGGCTGGTTCGTATTGATCGCAGGGGATTC
GACTGGCAAGAACAGTCCCCATATCTGCGGGCAGTCGATATTCTGCGGGCGCGACAGGCAACTGGTTTATTGAAAAGAAA
TCGTATTAGCGCAGCACGGTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10579.09 Da        Isoelectric Point: 5.6963

>AT239449 WP_015369791.1 NZ_CP094280:864477-864743 [Klebsiella aerogenes]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDDDKRLFIRLLENDDPDLFNWLMNHGKPADAQLQRMINLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT239449 NZ_LR890719:c4546258-4545908 [Klebsiella pneumoniae]
ATGTCGAATAAGACACTGACAGTGAATGATGATACTGCTGAGCCCTGGTGGGGTTTGAGTCGTAACGTCATCCCTTGTTT
TGGCGCACGTCTGGTTCAGGAAGGTAATCGCCTGCATTACCTGGCTGGCCGCGCCAGCTTAACAGGCCAGATCCATGAAG
CGGATTTACTCCATCTTGACCAGGCGTTCCCGGTACTGCTGAAGCAGATGGAGCTCATGCTTACCTGCGGCGAACTGAAT
CCACGACACCAGCACTGCGTCACGCTTTATGCGAAGGGGCTAACCTGCGAAGCTGATACGCTGGGCTCCTGCGGTTACGT
TTATATCGCCATTTACCCCACACAACGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3FM52

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3FJK6

References