Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 67407..68317 Replicon plasmid pNY1688-4
Accession NZ_CP094276
Organism Klebsiella aerogenes strain NY1688

Toxin (Protein)


Gene name - Uniprot ID A0A663AYG0
Locus tag MQE04_RS27940 Protein ID WP_004026354.1
Coordinates 67847..68317 (+) Length 157 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A2J4RLY9
Locus tag MQE04_RS27935 Protein ID WP_004181895.1
Coordinates 67407..67850 (+) Length 148 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MQE04_RS27920 (MQE04_27920) 63091..64122 + 1032 WP_029505552.1 hypothetical protein -
MQE04_RS27925 (MQE04_27925) 65613..66035 + 423 WP_004181893.1 translesion error-prone DNA polymerase V autoproteolytic subunit -
MQE04_RS27930 (MQE04_27930) 66035..67306 + 1272 WP_004181894.1 translesion error-prone DNA polymerase V subunit UmuC -
MQE04_RS27935 (MQE04_27935) 67407..67850 + 444 WP_004181895.1 DUF2384 domain-containing protein Antitoxin
MQE04_RS27940 (MQE04_27940) 67847..68317 + 471 WP_004026354.1 RES family NAD+ phosphorylase Toxin
MQE04_RS27945 (MQE04_27945) 68427..68687 - 261 WP_004026352.1 hypothetical protein -
MQE04_RS27950 (MQE04_27950) 69410..69568 + 159 WP_004181898.1 type I toxin-antitoxin system Hok family toxin -
MQE04_RS27955 (MQE04_27955) 70171..71145 + 975 WP_014386572.1 hypothetical protein -
MQE04_RS27960 (MQE04_27960) 71343..71720 - 378 WP_004181901.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid mph(E) / msr(E) / armA / sul1 / qacE / ARR-3 / catB3 / blaOXA-1 / aac(6')-Ib-cr - 1..239700 239700


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(3-148)

Antitoxin

Antitoxin Xre-like, helix-turn-helix domain

(30-89)


Sequences

Toxin        


Download         Length: 157 a.a.        Molecular weight: 17515.79 Da        Isoelectric Point: 4.6155

>T239445 WP_004026354.1 NZ_CP094276:67847-68317 [Klebsiella aerogenes]
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK

Download         Length: 471 bp

>T239445 NZ_LR890719:1837403-1837505 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 148 a.a.        Molecular weight: 16536.87 Da        Isoelectric Point: 10.3013

>AT239445 WP_004181895.1 NZ_CP094276:67407-67850 [Klebsiella aerogenes]
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVVNRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDREAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS

Download         Length: 444 bp

>AT239445 NZ_LR890719:c1837512-1837367 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A663AYG0

Antitoxin

Source ID Structure
AlphaFold DB A0A2J4RLY9

References