Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | /RES-TIGR02293 |
Location | 67407..68317 | Replicon | plasmid pNY1688-4 |
Accession | NZ_CP094276 | ||
Organism | Klebsiella aerogenes strain NY1688 |
Toxin (Protein)
Gene name | - | Uniprot ID | A0A663AYG0 |
Locus tag | MQE04_RS27940 | Protein ID | WP_004026354.1 |
Coordinates | 67847..68317 (+) | Length | 157 a.a. |
Antitoxin (Protein)
Gene name | - | Uniprot ID | A0A2J4RLY9 |
Locus tag | MQE04_RS27935 | Protein ID | WP_004181895.1 |
Coordinates | 67407..67850 (+) | Length | 148 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
MQE04_RS27920 (MQE04_27920) | 63091..64122 | + | 1032 | WP_029505552.1 | hypothetical protein | - |
MQE04_RS27925 (MQE04_27925) | 65613..66035 | + | 423 | WP_004181893.1 | translesion error-prone DNA polymerase V autoproteolytic subunit | - |
MQE04_RS27930 (MQE04_27930) | 66035..67306 | + | 1272 | WP_004181894.1 | translesion error-prone DNA polymerase V subunit UmuC | - |
MQE04_RS27935 (MQE04_27935) | 67407..67850 | + | 444 | WP_004181895.1 | DUF2384 domain-containing protein | Antitoxin |
MQE04_RS27940 (MQE04_27940) | 67847..68317 | + | 471 | WP_004026354.1 | RES family NAD+ phosphorylase | Toxin |
MQE04_RS27945 (MQE04_27945) | 68427..68687 | - | 261 | WP_004026352.1 | hypothetical protein | - |
MQE04_RS27950 (MQE04_27950) | 69410..69568 | + | 159 | WP_004181898.1 | type I toxin-antitoxin system Hok family toxin | - |
MQE04_RS27955 (MQE04_27955) | 70171..71145 | + | 975 | WP_014386572.1 | hypothetical protein | - |
MQE04_RS27960 (MQE04_27960) | 71343..71720 | - | 378 | WP_004181901.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Non-Mobilizable plasmid | mph(E) / msr(E) / armA / sul1 / qacE / ARR-3 / catB3 / blaOXA-1 / aac(6')-Ib-cr | - | 1..239700 | 239700 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 157 a.a. Molecular weight: 17515.79 Da Isoelectric Point: 4.6155
>T239445 WP_004026354.1 NZ_CP094276:67847-68317 [Klebsiella aerogenes]
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK
Download Length: 471 bp
>T239445 NZ_LR890719:1837403-1837505 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT
Antitoxin
Download Length: 148 a.a. Molecular weight: 16536.87 Da Isoelectric Point: 10.3013
>AT239445 WP_004181895.1 NZ_CP094276:67407-67850 [Klebsiella aerogenes]
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVVNRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDREAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVVNRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDREAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS
Download Length: 444 bp
>AT239445 NZ_LR890719:c1837512-1837367 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A663AYG0 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A2J4RLY9 |