Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4120677..4121296 Replicon chromosome
Accession NZ_CP094272
Organism Klebsiella aerogenes strain NY1688

Toxin (Protein)


Gene name Hha Uniprot ID A0A0H3FXE2
Locus tag MQE04_RS20105 Protein ID WP_015367918.1
Coordinates 4121078..4121296 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A0H3FPM3
Locus tag MQE04_RS20100 Protein ID WP_015367917.1
Coordinates 4120677..4121051 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MQE04_RS20090 (MQE04_20090) 4115836..4117035 + 1200 WP_020079451.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
MQE04_RS20095 (MQE04_20095) 4117058..4120204 + 3147 WP_015367916.1 multidrug efflux RND transporter permease subunit AcrB -
MQE04_RS20100 (MQE04_20100) 4120677..4121051 + 375 WP_015367917.1 Hha toxicity modulator TomB Antitoxin
MQE04_RS20105 (MQE04_20105) 4121078..4121296 + 219 WP_015367918.1 HHA domain-containing protein Toxin
MQE04_RS20110 (MQE04_20110) 4121428..4121991 + 564 WP_015367919.1 maltose O-acetyltransferase -
MQE04_RS20115 (MQE04_20115) 4122117..4122581 + 465 WP_015367920.1 YlaC family protein -
MQE04_RS20120 (MQE04_20120) 4122556..4124010 - 1455 WP_015367921.1 PLP-dependent aminotransferase family protein -
MQE04_RS20125 (MQE04_20125) 4124113..4124823 + 711 WP_224146718.1 GNAT family protein -
MQE04_RS20130 (MQE04_20130) 4124820..4124960 - 141 WP_003859006.1 type B 50S ribosomal protein L36 -
MQE04_RS20135 (MQE04_20135) 4124963..4125223 - 261 WP_015367923.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8569.96 Da        Isoelectric Point: 9.4828

>T239436 WP_015367918.1 NZ_CP094272:4121078-4121296 [Klebsiella aerogenes]
MSGKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T239436 NZ_LR890714:4510585-4510842 [Escherichia coli]
ATGAATTTATCCCGTCAGGAACAACATACCTTACACGTTCTCGCTAAAGGTAGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGCCCGTCAATGGCCAGCCCTATCGAATCAACACCACCGAGCTGAATAAAGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14464.21 Da        Isoelectric Point: 4.9045

>AT239436 WP_015367917.1 NZ_CP094272:4120677-4121051 [Klebsiella aerogenes]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNRGWVNDPTSAVNLQLNELIEHIATYALNYKIKYAEDNKLISQLDEYL
DDTFMLFSSYGINTSDLQKWRKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT239436 NZ_LR890714:4510854-4511405 [Escherichia coli]
ATGACAGTACACCACTTCACTTTTCATATCACAGATAAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAGTGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCCGCGTTATCGCTGCTAGCCC
GGTATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCGACCTTCAAAGGAGAAATGGATTCACCGCTGATGCAC
ATCCTCGCTCCCCTGGCGGTCATACCGGAATACCAAGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAATCACTCACCGCT
CAGCCCATGACCCTGACCGGCCACATCCGGTGCGCGCAGGCCCTGATGAAACCGGAGCACTGGCGTGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3FXE2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3FPM3

References