Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2782369..2783108 Replicon chromosome
Accession NZ_CP094272
Organism Klebsiella aerogenes strain NY1688

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag MQE04_RS13575 Protein ID WP_032705770.1
Coordinates 2782623..2783108 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A0H3FSM9
Locus tag MQE04_RS13570 Protein ID WP_015705366.1
Coordinates 2782369..2782635 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MQE04_RS13550 (MQE04_13550) 2778661..2779278 + 618 WP_047058775.1 response regulator -
MQE04_RS13555 (MQE04_13555) 2779374..2779871 + 498 WP_047080778.1 heme-binding protein -
MQE04_RS13560 (MQE04_13560) 2780276..2780806 + 531 WP_047058778.1 N-acetyltransferase -
MQE04_RS13565 (MQE04_13565) 2780861..2782096 - 1236 WP_020078885.1 MFS transporter -
MQE04_RS13570 (MQE04_13570) 2782369..2782635 + 267 WP_015705366.1 DUF1778 domain-containing protein Antitoxin
MQE04_RS13575 (MQE04_13575) 2782623..2783108 + 486 WP_032705770.1 GNAT family N-acetyltransferase Toxin
MQE04_RS13580 (MQE04_13580) 2783180..2784796 + 1617 WP_042897505.1 FAD-NAD(P)-binding protein -
MQE04_RS13585 (MQE04_13585) 2784915..2786015 + 1101 WP_129242673.1 NADH:flavin oxidoreductase/NADH oxidase -
MQE04_RS13590 (MQE04_13590) 2786072..2786230 - 159 WP_002903230.1 YqaE/Pmp3 family membrane protein -
MQE04_RS13595 (MQE04_13595) 2786491..2787561 + 1071 WP_015705361.1 mannonate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(27-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17573.23 Da        Isoelectric Point: 8.8793

>T239435 WP_032705770.1 NZ_CP094272:2782623-2783108 [Klebsiella aerogenes]
MGKISAPAPLSSHHQIAEFCCGETVLDQWLKQRGLKNQAQGAARTFVVCKEESHQVVGFYSLATGSVNHSEATGGLRRNM
PDPIPVIILARLAIDCAFHGQGLGADLLHDALLRSYRVAENVGVRALMVHALTDSAKRFYLHHGFKASTTQERTLFLALP
K

Download         Length: 486 bp

>T239435 NZ_LR890714:c4468980-4468771 [Escherichia coli]
ATGGTTGATTATCCAAAACGTGATGCTATTTCCAACATCAACGCTATAATTGTAGATACATTTTTGTATATACAATTAGG
GATGGCAACTATGCCAATGGAGTTTGAATGGAATGCAAACAAGGCCAAAAGTAATCGGGTGAAACATGGCATCCGCTTTG
AAGATGCGGTGTTAGTGCTTGATGATCCACAACGAACGGAGCCGCTATGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10085.56 Da        Isoelectric Point: 4.6558

>AT239435 WP_015705366.1 NZ_CP094272:2782369-2782635 [Klebsiella aerogenes]
MKSDIQLNIRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNLSDEQYAEFIDMLDAPVEANPALDKLL
ARKPQWEK

Download         Length: 267 bp

>AT239435 NZ_LR890714:c4468774-4468472 [Escherichia coli]
ATGAGCATGGTTAAACATAAACGAGGGACCTCCTCTACACTCGATGTGCAGCATGAGGCCGAACTGAAGGTGCTGGCGAA
CAAATTCGACGAGGATATTGATTACAGCGACATCCCATCTTCCAGCGATGAGCAATGGTCTAACGCAGAACGCGGTAAGT
TTTATCGGCCATTGAAAACTCAGGCTTCGGTGCGTATTGATGCTGATGTGATGGAATGGTTGAAGCGACCAGGTAAAGGC
TATCAAACTCGCCTGAACGCAATTTTACGTGAAGCGATGCTGCGCGATCAGAACAAAAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3FSM9

References