Detailed information of TA system TA239426

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yfjZ-ypjF/CbtA-CbeA
• Location: 904451..905124
• Replicon: chromosome
• Accession: NZ_CP094272
• Organism: Klebsiella aerogenes strain NY1688

Toxin (Protein)

• Gene name: ypjF
• Uniprot ID: -
• Locus tag: MQE04_RS04430
• Protein ID: WP_224147482.1
• Coordinates: 904789..905124 (+)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: yfjZ
• Uniprot ID: -
• Locus tag: MQE04_RS04425
• Protein ID: WP_224147479.1
• Coordinates: 904451..904768 (+)
• Length: 106 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MQE04_RS04380 (MQE04_04380)	899595..900419	+	825	WP_185773906.1	DUF932 domain-containing protein	-
MQE04_RS04385 (MQE04_04385)	900628..901338	+	711	WP_185773907.1	DeoR family transcriptional regulator	-
MQE04_RS04390 (MQE04_04390)	901364..901900	+	537	WP_185773908.1	DUF4339 domain-containing protein	-
MQE04_RS04395 (MQE04_04395)	901942..902379	+	438	WP_023301392.1	hypothetical protein	-
MQE04_RS04400 (MQE04_04400)	902446..902856	+	411	WP_087603038.1	hypothetical protein	-
MQE04_RS04405 (MQE04_04405)	902934..903170	+	237	WP_087603037.1	DUF905 domain-containing protein	-
MQE04_RS04410 (MQE04_04410)	903251..903709	+	459	WP_185773909.1	antirestriction protein	-
MQE04_RS04415 (MQE04_04415)	903725..904201	+	477	WP_182289204.1	RadC family protein	-
MQE04_RS04420 (MQE04_04420)	904210..904431	+	222	WP_185773910.1	DUF987 domain-containing protein	-
MQE04_RS04425 (MQE04_04425)	904451..904768	+	318	WP_224147479.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
MQE04_RS04430 (MQE04_04430)	904789..905124	+	336	WP_224147482.1	TA system toxin CbtA family protein	Toxin
MQE04_RS04440 (MQE04_04440)	906323..906808	+	486	Protein_872	hypothetical protein	-
MQE04_RS04445 (MQE04_04445)	907223..908023	-	801	WP_047046412.1	hypothetical protein	-
MQE04_RS04450 (MQE04_04450)	908200..908736	-	537	WP_032712343.1	dihydrofolate reductase family protein	-
MQE04_RS04455 (MQE04_04455)	908948..909865	-	918	WP_126027064.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	871643..910518	38875

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-105)

Antitoxin

• Antitoxin CbeA (5-103)

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 12729.82 Da
• Isoelectric Point: 6.7096

>T239426 WP_224147482.1 NZ_CP094272:904789-905124 [Klebsiella aerogenes]
MKTLPATTLWAAKPCPSPVIVWQMLLSRLLDQHYGLTLNDTPFSDETVIKEHIDAGISLADAVNFLVEKYELVRIDRKGF
SWQEQSPFITAVDILKARRAMREMRMTCPHD

Nucleotide

• Length: 336 bp

>T239426 NZ_LR890714:c2735905-2735729 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTAGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTAAAACTCAG
GTTTCACGGGAGGCGCAGTGTCATGCCGCGTCACCCCAGCGAAGAGATTAAAGAACCATTGCGTAAAGCCATTCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin

Protein

• Length: 106 a.a.
• Molecular weight: 11802.39 Da
• Isoelectric Point: 6.6236

>AT239426 WP_224147479.1 NZ_CP094272:904451-904768 [Klebsiella aerogenes]
MSNITWGLQRDITPRLGARLVQEGNRLHYLADRASITGKFSDAECLNLDVAFPHFISQIESMLTTGEQNPRHAHCVTLYH
NGFTCEVDTLGSCGYVYIAIYPTLR

Nucleotide

• Length: 318 bp

>AT239426 NZ_LR890714:c2735683-2735267 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
CCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATCAAATAGTCACGATCACTTTATTGAAGTGCCTTTGAGCGTCGCCTCTAAAGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAAAT
TACTCGCTTATTTAACTTGCACCATGCGACAAAAATCGACGCCGTCCAGCTTGCGGCTAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA