Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 283139..283770 Replicon chromosome
Accession NZ_CP094272
Organism Klebsiella aerogenes strain NY1688

Toxin (Protein)


Gene name hicA Uniprot ID A0A0H3FL31
Locus tag MQE04_RS01290 Protein ID WP_015703741.1
Coordinates 283139..283414 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0H3FNK6
Locus tag MQE04_RS01295 Protein ID WP_015703740.1
Coordinates 283411..283770 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MQE04_RS01270 (MQE04_01270) 278367..278702 + 336 WP_015703743.1 universal stress protein UspB -
MQE04_RS01275 (MQE04_01275) 278768..280264 - 1497 WP_015369272.1 inorganic phosphate transporter PitA -
MQE04_RS01280 (MQE04_01280) 280496..281689 + 1194 WP_047079885.1 NAD(P)/FAD-dependent oxidoreductase -
MQE04_RS01285 (MQE04_01285) 281729..282742 - 1014 WP_015369274.1 magnesium transporter -
MQE04_RS01290 (MQE04_01290) 283139..283414 + 276 WP_015703741.1 type II toxin-antitoxin system HicA family toxin Toxin
MQE04_RS01295 (MQE04_01295) 283411..283770 + 360 WP_015703740.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
MQE04_RS01300 (MQE04_01300) 283798..284199 - 402 WP_020077744.1 nickel-responsive transcriptional regulator NikR -
MQE04_RS01305 (MQE04_01305) 284187..284978 - 792 WP_020077745.1 nickel import ATP-binding protein NikE -
MQE04_RS01310 (MQE04_01310) 284975..285739 - 765 WP_020077746.1 nickel import ATP-binding protein NikD -
MQE04_RS01315 (MQE04_01315) 285739..286572 - 834 WP_032713130.1 nickel ABC transporter permease subunit NikC -
MQE04_RS01320 (MQE04_01320) 286569..287513 - 945 WP_015703735.1 nickel ABC transporter permease subunit NikB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10258.89 Da        Isoelectric Point: 10.4888

>T239424 WP_015703741.1 NZ_CP094272:283139-283414 [Klebsiella aerogenes]
MEQQVLSLRKKQRNTLEQLFKTPVPQGIKWADIESLIKALGGEIKEGRGSRCKFLLNHSIASFHRPHPSPDTDKGAVESV
RDWLITIGVKP

Download         Length: 276 bp

>T239424 NZ_LR890714:2315660-2315763 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13305.02 Da        Isoelectric Point: 4.3472

>AT239424 WP_015703740.1 NZ_CP094272:283411-283770 [Klebsiella aerogenes]
MIKPKTPNSMEIAGQPAVINYVPELNAFRGKFLGLSGYCDFVSDSIQGLQQEGEISLQEYLADCREAGIEPYAQPEKLKT
FTLRYPESFGERLSSAAAEEQVSVNTWILETLNERLKQA

Download         Length: 360 bp

>AT239424 NZ_LR890714:c2315801-2315530 [Escherichia coli]
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGCGGTGGCCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3FL31

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3FNK6

References