239423

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PP_4151-4152/excise(antitoxin)
Location 75631..76652 Replicon chromosome
Accession NZ_CP094272
Organism Klebsiella aerogenes strain NY1688

Toxin (Protein)


Gene name PP_4152 Uniprot ID A0A0G9UXE3
Locus tag MQE04_RS00375 Protein ID WP_032706547.1
Coordinates 76077..76652 (+) Length 192 a.a.

Antitoxin (Protein)


Gene name PP_4151 Uniprot ID A0A0G9R618
Locus tag MQE04_RS00370 Protein ID WP_015369110.1
Coordinates 75631..76077 (+) Length 149 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MQE04_RS00345 (MQE04_00345) 71152..71931 + 780 WP_015369105.1 MBL fold metallo-hydrolase -
MQE04_RS00350 (MQE04_00350) 71953..72906 + 954 WP_224147243.1 helix-turn-helix domain-containing protein -
MQE04_RS00355 (MQE04_00355) 72903..73952 - 1050 WP_224147234.1 NAD(P)-dependent alcohol dehydrogenase -
MQE04_RS00360 (MQE04_00360) 74110..74412 - 303 WP_015369108.1 putative quinol monooxygenase -
MQE04_RS00365 (MQE04_00365) 74413..75420 - 1008 WP_015369109.1 zinc-binding alcohol dehydrogenase family protein -
MQE04_RS00370 (MQE04_00370) 75631..76077 + 447 WP_015369110.1 helix-turn-helix domain-containing protein Antitoxin
MQE04_RS00375 (MQE04_00375) 76077..76652 + 576 WP_032706547.1 PIN domain-containing protein Toxin
MQE04_RS00380 (MQE04_00380) 76957..78153 + 1197 WP_015369112.1 hypothetical protein -
MQE04_RS00385 (MQE04_00385) 78330..79367 - 1038 WP_224147232.1 RhuM family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(8-115)

Antitoxin

SinI-like, DNA-binding domain

(79-126)


Sequences

Toxin        


Download         Length: 192 a.a.        Molecular weight: 21688.29 Da        Isoelectric Point: 6.2900

>T239423 WP_032706547.1 NZ_CP094272:76077-76652 [Klebsiella aerogenes]
MRHSPYPVILDACVLYPARLRDLLMHLGIAGLYQPKWSRFIHDEWCRNLLINRPDIAPEALRRTVDLMNAALPDANVTGF
AGLINGLVLPDPDDRHVLAAAIRAKAEIIVTLNHKDFPAESLLPFEIETLHPDVFISDLFDLNHALALEAVRRQRQSLKH
PPMTVDEFLEMLLKQGLPMTVKELANYQYAI

Download         Length: 576 bp

>T239423 NZ_LR890714:1295767-1296078 [Escherichia coli]
ATGCACATCATTTCGAAAGCGCCATTTGAAGAGTGTGCGCGCAAATATCCTAACGACGCTCTGGCTCTACACTCATTGTA
TCGGGTTATTAAGGAAACGGATTTTTCTACACCAGAAGAAATGCGAACGGCGTTTCCTAACCTCGACAATTTTAAATATC
GCAACAAATGGTACGTTCTGGATGTCGGCGGGAACAATCTTAGGGTTATTGCCTACATAAACTTTGTTAATAAGCGGTTC
TTTGTGAAGCACATAACGAATCACGCAGAGTATGACAAACTGACACGTTACTACAGAGAGAACAAAGAATGA

Antitoxin


Download         Length: 149 a.a.        Molecular weight: 16699.26 Da        Isoelectric Point: 6.2257

>AT239423 WP_015369110.1 NZ_CP094272:75631-76077 [Klebsiella aerogenes]
MTKLNLPDPLESELAQRGQRELAAYLSTHLETQRIAIVGEDDKTHTIELPTSALTMLMEILGELACGNAVQIVPVHAELT
TQEAANILNVSRPHMVKLLEARKLPFHKTGRHRRVLFADLMEYKKRREQESLDAMQALADQAQDLGMY

Download         Length: 447 bp

>AT239423 NZ_LR890714:1296075-1296494 [Escherichia coli]
ATGACTGCTAATGCTGCACGCGCTGTTAAAGCAACAAGAGAACTGGTCAATGCAGTCCCCTTTCTGGGAGGCAGTGACTC
AGAAGATGATTATCGTGAAGCACTGGAACTGGTCGAATATTTGATTGAAGAAGATGACACCAATCCACTTATCGACTTTC
TGGCGAGCCGCATTGCAGAATATGAAAACAACAACGAAAAGTTTGCAGAGTTCGACAAAGCCGTTGCAGCAATGCCGGTT
GGCGTGGCCTTACTTCGTACGCTGATTGATCAACATAATTTGACCTATGCGGATTTGAAGAACGAAATCGGCTCTAAATC
TCTGGTCAGTCAGATTTTGTCTGGGCAACGATCCCTGACGATATCCCATATTAAGGCACTTTCAGCCCGATTTGGCGTTA
AGCCGGAATGGTTTCTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0G9UXE3

Antitoxin

Source ID Structure
AlphaFold DB A0A0G9R618

References