Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-DnaT |
| Location | 30086..30608 | Replicon | plasmid pSE228B |
| Accession | NZ_CP094271 | ||
| Organism | Salmonella enterica subsp. enterica serovar Enteritidis strain JL228 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | D0QMR1 |
| Locus tag | MPK88_RS24395 | Protein ID | WP_000220561.1 |
| Coordinates | 30086..30367 (-) | Length | 94 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | G3CAG1 |
| Locus tag | MPK88_RS24400 | Protein ID | WP_000121743.1 |
| Coordinates | 30357..30608 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MPK88_RS24355 (MPK88_24315) | 26068..26613 | - | 546 | WP_000757692.1 | DNA distortion polypeptide 1 | - |
| MPK88_RS24360 (MPK88_24320) | 26939..27211 | - | 273 | WP_000167280.1 | hypothetical protein | - |
| MPK88_RS24365 (MPK88_24325) | 27444..27623 | - | 180 | WP_000439079.1 | hypothetical protein | - |
| MPK88_RS24370 (MPK88_24330) | 27666..27995 | - | 330 | WP_000866654.1 | hypothetical protein | - |
| MPK88_RS24375 (MPK88_24335) | 28089..28331 | - | 243 | WP_000008708.1 | hypothetical protein | - |
| MPK88_RS24380 (MPK88_24340) | 28321..28590 | - | 270 | WP_001006718.1 | hypothetical protein | - |
| MPK88_RS24385 (MPK88_24345) | 28599..29147 | - | 549 | WP_001178641.1 | hypothetical protein | - |
| MPK88_RS24390 (MPK88_24350) | 29221..29736 | - | 516 | WP_001025387.1 | J domain-containing protein | - |
| MPK88_RS24395 (MPK88_24355) | 30086..30367 | - | 282 | WP_000220561.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| MPK88_RS24400 (MPK88_24360) | 30357..30608 | - | 252 | WP_000121743.1 | plasmid stabilization protein | Antitoxin |
| MPK88_RS24405 (MPK88_24365) | 31673..32542 | + | 870 | WP_001212191.1 | replication initiation protein | - |
| MPK88_RS24410 (MPK88_24370) | 32547..33398 | + | 852 | WP_000435059.1 | replication initiation protein | - |
| MPK88_RS24415 (MPK88_24375) | 33402..33847 | + | 446 | Protein_39 | hypothetical protein | - |
| MPK88_RS24420 (MPK88_24380) | 33984..34337 | + | 354 | WP_024156393.1 | DNA distortion polypeptide 3 | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | armA / sul1 / qacE / aac(6')-Ib-cr / aac(3)-IId / blaTEM-1B / aph(6)-Id / aph(3'')-Ib / sul2 / aph(3')-Ia / mph(E) | - | 1..54608 | 54608 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 94 a.a. Molecular weight: 11023.86 Da Isoelectric Point: 10.5938
>T239422 WP_000220561.1 NZ_CP094271:c30367-30086 [Salmonella enterica subsp. enterica serovar Enteritidis]
MTYELAFDRRALKEWQKLGHTIREQFKKKLAERLENPRVPAARLHGHADRYKIKLRASGYRLVYQVIDEKVVLLVIAVGR
RESSEVYQIADMR
MTYELAFDRRALKEWQKLGHTIREQFKKKLAERLENPRVPAARLHGHADRYKIKLRASGYRLVYQVIDEKVVLLVIAVGR
RESSEVYQIADMR
Download Length: 282 bp
>T239422 NZ_LR890714:1221776-1222111 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCCGG
ACATCGTCCGGCTGTTGTCCTGAGTCCGTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACGGTTGCCCCAGAGGAATTACAGCTCATTAAAGCCAAAATTAA
CGTGCTGATTGGGTAG
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCCGG
ACATCGTCCGGCTGTTGTCCTGAGTCCGTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACGGTTGCCCCAGAGGAATTACAGCTCATTAAAGCCAAAATTAA
CGTGCTGATTGGGTAG
Antitoxin
Download Length: 84 a.a. Molecular weight: 9194.43 Da Isoelectric Point: 4.1683
>AT239422 WP_000121743.1 NZ_CP094271:c30608-30357 [Salmonella enterica subsp. enterica serovar Enteritidis]
MSYQILTTTAASITDLKKNPMGTVAEGEGDAVAILNRNEPAFYCVPPKLYAYYRELAEDAELNAVADERMKNPEIVKVNL
DDL
MSYQILTTTAASITDLKKNPMGTVAEGEGDAVAILNRNEPAFYCVPPKLYAYYRELAEDAELNAVADERMKNPEIVKVNL
DDL
Download Length: 252 bp
>AT239422 NZ_LR890714:1221528-1221776 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3S5I302 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3S5I301 |