Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 200371..201131 Replicon chromosome
Accession NZ_CP094269
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain JL228

Toxin (Protein)


Gene name tacT Uniprot ID A0A1R2W0C7
Locus tag MPK88_RS00930 Protein ID WP_000533912.1
Coordinates 200646..201131 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID M7RHS4
Locus tag MPK88_RS00925 Protein ID WP_000965886.1
Coordinates 200371..200658 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MPK88_RS00905 (195776) 195776..196687 + 912 WP_001168551.1 glycine--tRNA ligase subunit alpha -
MPK88_RS00910 (196697) 196697..198766 + 2070 WP_001291741.1 glycine--tRNA ligase subunit beta -
MPK88_RS00915 (199156) 199156..199554 + 399 Protein_181 IS3 family transposase -
MPK88_RS00920 (199726) 199726..200193 + 468 WP_000702452.1 GNAT family N-acetyltransferase -
MPK88_RS00925 (200371) 200371..200658 + 288 WP_000965886.1 DUF1778 domain-containing protein Antitoxin
MPK88_RS00930 (200646) 200646..201131 + 486 WP_000533912.1 GNAT family N-acetyltransferase Toxin
MPK88_RS00935 (201502) 201502..202041 - 540 WP_000047147.1 copper-binding periplasmic metallochaperone CueP -
MPK88_RS00940 (202215) 202215..202427 - 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
MPK88_RS00945 (202715) 202715..203005 - 291 WP_000455790.1 HTH-type transcriptional regulator -
MPK88_RS00950 (203444) 203444..204154 + 711 WP_000190524.1 DUF3053 domain-containing protein -
MPK88_RS00955 (204204) 204204..205178 - 975 WP_000804678.1 glyoxylate/hydroxypyruvate reductase GhrB -
MPK88_RS00960 (205397) 205397..206059 - 663 WP_000747548.1 OmpA family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(5-94)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17731.46 Da        Isoelectric Point: 9.8719

>T239394 WP_000533912.1 NZ_CP094269:200646-201131 [Salmonella enterica subsp. enterica serovar Enteritidis]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEVTGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

>T239394 NZ_LR890702:4220185-4220469 [Klebsiella pneumoniae]
ATGACCTATGAACTGGCGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10950.60 Da        Isoelectric Point: 4.6811

>AT239394 WP_000965886.1 NZ_CP094269:200371-200658 [Salmonella enterica subsp. enterica serovar Enteritidis]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp

>AT239394 NZ_LR890702:4219953-4220195 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGTTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1R2W0C7

Antitoxin

Source ID Structure
PDB 7AK8
AlphaFold DB A0A3V2JDX2

References