Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/-
Location 2544573..2545209 Replicon chromosome
Accession NZ_CP094258
Organism Acinetobacter indicus strain BDT201

Toxin (Protein)


Gene name cptA Uniprot ID N9KY14
Locus tag MOW14_RS12130 Protein ID WP_005180237.1
Coordinates 2544573..2544965 (-) Length 131 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID N9KY84
Locus tag MOW14_RS12135 Protein ID WP_005180238.1
Coordinates 2544952..2545209 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MOW14_RS12115 (MOW14_12115) 2539898..2542174 - 2277 WP_127799343.1 TRAP transporter large permease subunit -
MOW14_RS12120 (MOW14_12120) 2542355..2542927 - 573 WP_127799341.1 rhombosortase -
MOW14_RS12125 (MOW14_12125) 2542983..2544056 - 1074 WP_016658537.1 hypothetical protein -
MOW14_RS12130 (MOW14_12130) 2544573..2544965 - 393 WP_005180237.1 hypothetical protein Toxin
MOW14_RS12135 (MOW14_12135) 2544952..2545209 - 258 WP_005180238.1 succinate dehydrogenase assembly factor 2 Antitoxin
MOW14_RS12140 (MOW14_12140) 2545393..2546565 + 1173 WP_075167404.1 acyl-CoA dehydrogenase family protein -
MOW14_RS12145 (MOW14_12145) 2546653..2548143 - 1491 WP_104483957.1 NAD(P)/FAD-dependent oxidoreductase -
MOW14_RS12150 (MOW14_12150) 2548341..2548706 - 366 WP_004754212.1 50S ribosomal protein L17 -
MOW14_RS12155 (MOW14_12155) 2548726..2549733 - 1008 WP_005180245.1 DNA-directed RNA polymerase subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Flavinator of succinate dehydrogenase

(10-82)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14930.64 Da        Isoelectric Point: 10.4540

>T239390 WP_005180237.1 NZ_CP094258:c2544965-2544573 [Acinetobacter indicus]
MSTAKRDFQLKPSRLALLFQLSLLILFSVLSFQLLHPLLWLLGLLLAAVSYYGFQRRSQLTALAHLDGAEWSLQFNSGSK
IQRGLLEHILDHQLYLVLYFHHAPVKSAVIWRDQVSFAEWKALKTLAKTI

Download         Length: 393 bp

>T239390 NZ_LR890702:c1538027-1537925 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10220.62 Da        Isoelectric Point: 4.6150

>AT239390 WP_005180238.1 NZ_CP094258:c2545209-2544952 [Acinetobacter indicus]
MSEDISLEERKVIYRARRGLKEIDVYFDPYVKNYYLTADPEEKATFAALVEQEDPDLLDWFMEVSEPPRPEMRELIRKLK
HYVHG

Download         Length: 258 bp

>AT239390 NZ_LR890702:1537918-1538063 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB N9KY14

Antitoxin

Source ID Structure
AlphaFold DB N9KY84

References