Detailed information of TA system TA239387

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/-
• Location: 2697842..2698478
• Replicon: chromosome
• Accession: NZ_CP094254
• Organism: Acinetobacter indicus strain BDT2076

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: N9KY14
• Locus tag: MOW12_RS12865
• Protein ID: WP_005180237.1
• Coordinates: 2697842..2698234 (-)
• Length: 131 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: N9KY84
• Locus tag: MOW12_RS12870
• Protein ID: WP_005180238.1
• Coordinates: 2698221..2698478 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MOW12_RS12840 (MOW12_12840)	2692955..2693104	+	150	Protein_2472	EamA/RhaT family transporter	-
MOW12_RS12845 (MOW12_12845)	2693166..2695442	-	2277	WP_127799343.1	TRAP transporter large permease subunit	-
MOW12_RS12850 (MOW12_12850)	2695623..2696195	-	573	WP_127799341.1	rhombosortase	-
MOW12_RS12855 (MOW12_12855)	2696251..2697324	-	1074	WP_127799339.1	hypothetical protein	-
MOW12_RS12860 (MOW12_12860)	2697449..2697694	+	246	WP_075167406.1	hypothetical protein	-
MOW12_RS12865 (MOW12_12865)	2697842..2698234	-	393	WP_005180237.1	hypothetical protein	Toxin
MOW12_RS12870 (MOW12_12870)	2698221..2698478	-	258	WP_005180238.1	succinate dehydrogenase assembly factor 2	Antitoxin
MOW12_RS12875 (MOW12_12875)	2698662..2699834	+	1173	WP_075167404.1	acyl-CoA dehydrogenase family protein	-
MOW12_RS12880 (MOW12_12880)	2699922..2701412	-	1491	WP_127799337.1	NAD(P)/FAD-dependent oxidoreductase	-
MOW12_RS12885 (MOW12_12885)	2701611..2701976	-	366	WP_004754212.1	50S ribosomal protein L17	-
MOW12_RS12890 (MOW12_12890)	2701996..2703003	-	1008	WP_005180245.1	DNA-directed RNA polymerase subunit alpha	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	2692182..2692901	719

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Flavinator of succinate dehydrogenase (10-82)

Sequences

Toxin

Protein

• Length: 131 a.a.
• Molecular weight: 14930.64 Da
• Isoelectric Point: 10.4540

>T239387 WP_005180237.1 NZ_CP094254:c2698234-2697842 [Acinetobacter indicus]
MSTAKRDFQLKPSRLALLFQLSLLILFSVLSFQLLHPLLWLLGLLLAAVSYYGFQRRSQLTALAHLDGAEWSLQFNSGSK
IQRGLLEHILDHQLYLVLYFHHAPVKSAVIWRDQVSFAEWKALKTLAKTI

Nucleotide

• Length: 393 bp

>T239387 NZ_LR890694:c98610-98305 [Escherichia coli]
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTATCGTCTGTTTGTGGATGTACAGAGTGATATTATTGACAC
GCCCGGGCGACGGATGGTGATCCCCCTGGCCAGTGCACGTCTGCTGTCAGATAAAGTCTCCCGTGAACTTTACCCGGTGG
TGCATATCGGGGATGAAAGCTGGCGCATGATGACCACCGATATGGCCAGTGTGCCGGTCTCCGTTATCGGGGAAGAAGTG
GCTGATCTCAGCCACCGCGAAAATGACATCAAAAACGCCATTAACCTGATGTTCTGGGGAATATAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 10220.62 Da
• Isoelectric Point: 4.6150

>AT239387 WP_005180238.1 NZ_CP094254:c2698478-2698221 [Acinetobacter indicus]
MSEDISLEERKVIYRARRGLKEIDVYFDPYVKNYYLTADPEEKATFAALVEQEDPDLLDWFMEVSEPPRPEMRELIRKLK
HYVHG

Nucleotide

• Length: 258 bp

>AT239387 NZ_LR890694:c98830-98612 [Escherichia coli]
ATGAAGCAGCGTATTACAGTGACAGTTGACAGCGACAGCTATCAGTTGCTCAAGGCATATGATGTCAATATCTCCGGTCT
GGTAAGCACAACCATGCAGAATGAAGCCCGTCGTCTGCGTGCCGAACGCTGGAAAGCGGAAAATCAGGAAGGGATGGCTG
AGGTCGCCCGGTTTATTGAAATGAACGGCTCTTTTGCTGACGAGAACAGGGACTGGTGA

Structures

Toxin

• AlphaFold DB: N9KY14

Antitoxin

• AlphaFold DB: N9KY84